Schizophrenia delays and alters maturation of the brain in adolescence. by Douaud, G, Mackay, C, Andersson, J, James, S, Quested, D, Ray, M, Connell, J, Roberts, N, Crow, T, Matthews, P, Smith, S, James, A

“…Taken together, these results suggest common aetiological mechanisms for adolescent- and adult-onset schizophrenia with an altered neurodevelopmental time course in the schizophrenic patients that is particularly salient in adolescence.…”

Schizophrenia delays and alters maturation of the brain in adolescence by Douaud, G, Mackay, C, Andersson, J, James, S, Quested, D, Ray, M, Connell, J, Roberts, N, Crow, T, Matthews, P, Smith, S, James, A

“…Taken together, these results suggest common aetiological mechanisms for adolescent- and adult-onset schizophrenia with an altered neurodevelopmental time course in the schizophrenic patients that is particularly salient in adolescence.…”

Changes in white matter microstructure during adolescence. by Giorgio, A, Watkins, K, Douaud, G, James, A, James, S, De Stefano, N, Matthews, P, Smith, S, Johansen-Berg, H

“…Postmortem histological studies have demonstrated that myelination in human brain white matter (WM) continues throughout adolescence and well into adulthood. We used in vivo diffusion-weighted magnetic resonance imaging to test for age-related WM changes in 42 adolescents and 20 young adults. …”

Developmental changes in white matter microstructure in adolescence by Giorgio, A, Watkins, K, Douaud, G, Behrens, T, Matthews, P, James, A, James, S, Smith, S, Johansen-Berg, H

Longitudinal changes in grey and white matter during adolescence. by Giorgio, A, Watkins, K, Chadwick, M, James, S, Winmill, L, Douaud, G, De Stefano, N, Matthews, P, Smith, S, Johansen-Berg, H, James, A

“…Brain development continues actively during adolescence. Previous MRI studies have shown complex patterns of apparent loss of grey matter (GM) volume and increases in white matter (WM) volume and fractional anisotropy (FA), an index of WM microstructure. …”

ABC of adolescence - Suicide and deliberate self harm in young people by Hawton, K, James, A

Dissociable auditory mismatch response and connectivity patterns in adolescents with schizophrenia and adolescents with bipolar disorder with psychosis: A magnetoencephalography study. by Braeutigam, S, Dima, D, Frangou, S, James, A

“…</p> <h4>Objective</h4> <p>To examine the neuronal auditory response elicited by a roving mismatch negativity (MMN) paradigm using magnetoencephalography (MEG)</p> <h4>Participants</h4> <p>15 Adolescents with schizophrenia (ASZ), 16 adolescents with bipolar disorder with psychosis (ABP), and 14 typically developing individuals (TD).…”

Lobar and hemispheric lengths in adolescent onset schizophrenia by Clark, G, Mackay, C, James, A, Phillips, T, Roberts, N, Crow, T

Abnormality of the semantic network in adolescent subjects with schizophrenia by Chance, SA, Collinson, S, James, A, Crow, T

Automated analyses of cerebral asymmetry in adolescent onset psychosis by Clark, G, Mackay, C, Barrick, T, James, A, Roberts, N, Crow, T

Evidence for abnormalities of cortical development in adolescent-onset schizophrenia. by Voets, N, Hough, MG, Douaud, G, Matthews, P, James, A, Winmill, L, Webster, P, Smith, S

“…Our results emphasize widespread, but focally distinct cortical pathology in adolescent-onset schizophrenia. Evidence for changes in local surface area (as opposed to simply cortical thinning) is consistent with a neurodevelopmental contribution to the underlying neuropathology of the disease.…”

Loss of planum temporale asymmetry in adolescent onset psychosis by Clark, G, Mackay, C, Collinson, S, Barrick, T, James, A, Roberts, N, Crow, T

Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2year follow-up by Palaniyappan, L, Crow, T, Hough, M, Voets, N, Liddle, P, James, S, Winmill, L, James, A

“…By studying gyrification at illness onset in adolescence we hoped to clarify the pathophysiology of schizophrenia. …”

Gyrification of Broca's region is anomalously lateralized at onset of schizophrenia in adolescence and regresses at 2 year follow-up. by Palaniyappan, L, Crow, T, Hough, M, Voets, N, Liddle, P, James, S, Winmill, L, James, A

“…By studying gyrification at illness onset in adolescence we hoped to clarify the pathophysiology of schizophrenia. …”

Sexually dimorphic white matter geometry abnormalities in adolescent onset schizophrenia. by Savadjiev, P, Whitford, T, Hough, M, Clemm von Hohenberg, C, Bouix, S, Westin, C, Shenton, M, Crow, T, James, A, Kubicki, M

“…To provide evidence toward this theory, we analyze the geometry of interhemispheric white matter connections in adolescent-onset schizophrenia, with a particular focus on sex, using a recently introduced framework for white matter geometry computation in diffusion tensor imaging data (Savadjiev P, Kindlmann GL, Bouix S, Shenton ME, Westin CF. 2010. …”

Asymmetry loss is local rather than global in adolescent onset schizophrenia. by Clark, G, Crow, T, Barrick, T, Collinson, S, James, A, Roberts, N, Mackay, C

“…Here the discrepancy is examined in adolescence. Unbiased PT asymmetry and torque measures were obtained on 35 adolescents with schizophrenia or schizoaffective disorder and 31 adolescent controls. …”

Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. by Douaud, G, Smith, S, Jenkinson, M, Behrens, T, Johansen-Berg, H, Vickers, J, James, S, Voets, N, Watkins, K, Matthews, P, James, A

“…Our aim was to investigate structural grey and white matter abnormalities in adolescent-onset schizophrenia. Whole-brain voxel-wise investigation of both grey matter topography and white matter integrity (Fractional Anisotropy) were carried out on 25 adolescent-onset schizophrenic patients and 25 healthy adolescents. …”

Abnormal functional correlate precedes loss of structural asymmetry in the paracingulate sulcus in adolescent psychosis by Clark, G, Mackay, C, Davidson, M, Collinson, S, James, A, Roberts, N, Crow, T

Anxious and non-anxious adolescents' experiences of non-clinical magnetic resonance imaging research. by Haddad, A, Platt, B, James, A, Lau, J

“…Magnetic resonance imaging (MRI) has become a ubiquitous research tool for developmental neuroscientists interested in brain structure and function in children and adolescents. However, ethical concerns are sometimes raised about using MRI with children and adolescents, especially when participants have anxiety. …”

Anxious and non-anxious adolescents' experiences of non-clinical magnetic resonance imaging research by Haddad, ADM, Platt, B, James, A, Lau, J

“…Magnetic resonance imaging (MRI) has become a ubiquitous research tool for developmental neuroscientists interested in brain structure and function in children and adolescents. However, ethical concerns are sometimes raised about using MRI with children and adolescents, especially when participants have anxiety. …”