Protection against lung pathology during obesity-accelerated ageing in mice by the parasitic worm product ES-62 by Margaret M. Harnett, Felicity E. Lumb, Jenny Crowe, James Doonan, Geraldine Buitrago, Stephanie Brown, Gillian Thom, Amy MacDonald, Colin J. Suckling, Colin Selman, William Harnett

“…ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is immunomodulatory by virtue of covalently attached phosphorylcholine (PC) moieties. …”
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The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner by Margaret M. Harnett, James Doonan, Anuradha Tarafdar, Miguel A. Pineda, Josephine Duncombe-Moore, Geraldine Buitrago, Piaopiao Pan, Paul A. Hoskisson, Colin Selman, William Harnett

“…The parasitic worm-derived immunomodulator, ES-62 rescues defective levels of IL-10-producing regulatory B cells (Bregs) and suppresses chronic Th1/Th17-driven inflammation to protect against joint destruction in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis. …”
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