Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study by Fedirko, V, Tran, H, Gewirtz, A, Stepien, M, Trichopoulou, A, Aleksandrova, K, Olsen, A, Tjønneland, A, Overvad, K, Carbonnel, F, Boutron-Ruault, M, Severi, G, Kühn, T, Kaaks, R, Boeing, H, Bamia, C, Lagiou, P, Grioni, S, Panico, S, Palli, D, Tumino, R, Naccarati, A, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Castaño, J, Barricarte, A, Sánchez, M, Dorronsoro, M, Quirós, J, Agudo, A, Sjöberg, K, Ohlsson, B, Hemmingsson, O, Werner, M, Bradbury, K, Khaw, K, Wareham, N, Tsilidis, K, Aune, D, Scalbert, A, Romieu, I, Riboli, E, Jenab, M

“…</p><p>METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. …”

Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. by Dahm, C, Gorst-Rasmussen, A, Crowe, F, Roswall, N, Tjønneland, A, Drogan, D, Boeing, H, Teucher, B, Kaaks, R, Adarakis, G, Zylis, D, Trichopoulou, A, Fedirko, V, Chajes, V, Jenab, M, Palli, D, Pala, V, Tumino, R, Ricceri, F, van Kranen, H, Bueno-de-Mesquita, H, Quirós, JR, Sánchez, M, Luján-Barroso, L, Larrañaga, N

“…DESIGN: We reanalyzed previously published data from a case-control study of prostate cancer nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. …”

Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). by Travis, R, Crowe, F, Allen, N, Appleby, P, Roddam, A, Tjønneland, A, Olsen, A, Linseisen, J, Kaaks, R, Boeing, H, Kröger, J, Trichopoulou, A, Dilis, V, Trichopoulos, D, Vineis, P, Palli, D, Tumino, R, Sieri, S, Bueno-de-Mesquita, H, van Duijnhoven, F, Chirlaque, MD, Barricarte, A, Larrañaga, N, González, C, Argüelles, M, Sánchez, M, Stattin, P, Hallmans, G, Khaw, K, Bingham, S, Rinaldi, S, Slimani, N, Jenab, M, Riboli, E, Key, T

“…The authors examined whether vitamin D concentrations were associated with prostate cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (1994-2000). …”

Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. by Leufkens, A, van Duijnhoven, F, Woudt, S, Siersema, P, Jenab, M, Jansen, E, Pischon, T, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Pala, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Lukanova, A, Boeing, H, Aleksandrova, K, Trichopoulou, A, Trichopoulos, D, Dilis, V

“…This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Soluble receptor for advanced glycation end-products (sRAGE) and colorectal cancer risk: a case–control study nested within a European prospective cohort by Aglago, EK, Rinaldi, S, Freisling, H, Jiao, L, Hughes, DJ, Fedirko, V, Schalkwijk, CG, Weiderpass, E, Dahm, CC, Overvad, K, Eriksen, AK, Kyrø, C, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Katzke, V, Kühn, T, Schulze, MB, Aleksandrova, K, Masala, G, Krogh, V, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, B, van Gils, CH, Sandanger, TM, Gram, IT, Skeie, G, Quirós, JR, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Ardanaz, E, Johansson, I, Harlid, S, Perez-Cornago, A, Mayén, A-L, Cordova, R, Gunter, MJ, Vineis, P, Cross, AJ, Riboli, E, Jenab, M

“…</p> <p><strong>Methods:</strong> To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study by Huang, J, Zagai, U, Hallmans, G, Nyrén, O, Engstrand, L, Stolzenberg-Solomon, R, Duell, E, Overvad, K, Katzke, V, Kaaks, R, Jenab, M, Park, J, Murillo, R, Trichopoulou, A, Lagiou, P, Bamia, C, Bradbury, K, Riboli, E, Aune, D, Tsilidis, K, Capellá, G, Agudo, A, Krogh, V, Palli, D, Panico, S, Weiderpass, E, Tjønneland, A, Olsen, A, Martínez, B, Redondo-Sanchez, D, Chirlaque, M, Hm Peeters, P, Regnér, S, Lindkvist, B, Naccarati, A, Ardanaz, E, Larrañaga, N, Boutron-Ruault, M, Rebours, V, Barré, A, Bueno-de-Mesquita, H, Ye, W

“…The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. …”

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer by Butt, J, Jenab, M, Willhauck-Fleckenstein, M, Bradbury, K, al., E

“…We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case-control study nested within a prospective cohort. Pre-diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to eleven SGG proteins using multiplex serology. …”

Investigating sources of variability in metabolomic data in the EPIC study: the Principal Component Partial R-square (PC-PR2) method by Fages, A, Ferrari, P, Monni, S, Dossus, L, Floegel, A, Mode, N, Johansson, M, Travis, R, Bamia, C, Sanchez-Perez, M, Chiodini, P, Boshuizen, H, Chadeau-Hyam, M, Riboli, E, Jenab, M, Elena-Herrmann, B

“…Within the European Prospective Investigation into Cancer and nutrition (EPIC), metabolic profiles were determined by 1H NMR analysis on 807 serum samples originating from a nested liver cancer case-control study. PC-PR2 was used to quantify the variability of metabolomic profiles in terms of study subjects age, sex, body mass index, country of origin, smoking status, diabetes and fasting status, as well as factors related to sample processing. …”

Blood metabolic signatures of body mass index: a targeted metabolomics study in the EPIC Cohort by Carayol, M, Leitzmann, MF, Ferrari, P, Zamora-Ros, R, Achaintre, D, Stepien, M, Schmidt, JA, Travis, RC, Overvad, K, Tjønneland, A, Hansen, L, Kaaks, R, Kühn, T, Boeing, H, Bachlechner, U, Trichopoulou, A, Bamia, C, Palli, D, Agnoli, C, Tumino, R, Vineis, P, Panico, S, Quirós, JR, Sánchez-Cantalejo, E, Huerta, JM, Ardanaz, E, Arriola, L, Agudo, A, Nilsson, J, Melander, O, Bueno-de-Mesquita, B, Peeters, PH, Wareham, N, Khaw, KT, Jenab, M, Key, TJ, Scalbert, A, Rinaldi, S

“…Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). …”

Metabolic Mediators of the association between adult weight gain and Colorectal cancer: Data from European prospective investigation into Cancer and nutrition (EPIC) Cohort by Bradbury, K, Aleksandrova, K, Schlesinger, S, Fedirko, V, Jenab, M, Bueno-de-Mesquita, B, Freisling, H, Romieu, I, Pischon, T, Kaaks, R, Gunter, M, Dahm, C, Overvad, K, Rostgaard-Hansen, A, Tjønneland, A, Bamia, C, Lagiou, P, Agnoli, C, Mattielo, A, Khaw, K, Riboli, E, Boeing, H

“…We evaluated the mediation effect of 20 different biomarkers on the relation between adult weight gain and colorectal cancer using data from a prospective nested case-control study among 452 incident cases diagnosed between 1992 and 2003, and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition Cohort. …”

Plasma cotinine levels and pancreatic cancer in the EPIC cohort study. by Leenders, M, Chuang, S, Dahm, C, Overvad, K, Ueland, P, Midttun, O, Vollset, SE, Tjønneland, A, Halkjaer, J, Jenab, M, Clavel-Chapelon, F, Boutron-Ruault, M, Kaaks, R, Canzian, F, Boeing, H, Weikert, C, Trichopoulou, A, Bamia, C, Naska, A, Palli, D, Pala, V, Mattiello, A, Tumino, R, Sacerdote, C, van Duijnhoven, F

“…This study on pancreatic cancer, nested within the European Prospective Investigation into Cancer and Nutrition (EPIC cohort), included 146 cases and 146 matched controls. …”

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study by Michaud, D, Izard, J, Wilhelm-Benartzi, C, You, D, Grote, V, Tjønneland, A, Dahm, C, Overvad, K, Jenab, M, Fedirko, V, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Kaaks, R, Boeing, H, Foerster, J, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Sieri, S, Palli, D, Tumino, R, Panico, S, Siersema, P

“…Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. …”

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. by Michaud, D, Izard, J, Wilhelm-Benartzi, C, You, D, Grote, V, Tjønneland, A, Dahm, C, Overvad, K, Jenab, M, Fedirko, V, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Kaaks, R, Boeing, H, Foerster, J, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Sieri, S, Palli, D, Tumino, R, Panico, S, Siersema, P

“…DESIGN: We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. …”

Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European cohort. by Schlesinger, S, Aleksandrova, K, Pischon, T, Jenab, M, Fedirko, V, Trepo, E, Overvad, K, Roswall, N, Tjønneland, A, Boutron-Ruault, M, Fagherazzi, G, Racine, A, Kaaks, R, Grote, V, Boeing, H, Trichopoulou, A, Pantzalis, M, Kritikou, M, Mattiello, A, Sieri, S, Sacerdote, C, Palli, D, Tumino, R, Peeters, P, Bueno-de-Mesquita, H

“…Multivariable adjusted relative risks and 95% confidence intervals were estimated from Cox regression models. In a nested case-control subset, analyses were carried out in HCV/HBV-negative individuals. …”

Dietary intake of heme iron and risk of gastric cancer in the European prospective investigation into cancer and nutrition study. by Jakszyn, P, Agudo, A, Lujan-Barroso, L, Bueno-de-Mesquita, H, Jenab, M, Navarro, C, Palli, D, Boeing, H, Manjer, J, Numans, M, Igali, L, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Grioni, S, Panico, C, Tumino, R, Sacerdote, C, Quirós, JR, Molina-Montes, E, Huerta Castaño, J, Barricarte, A, Amiano, P, Khaw, K, Wareham, N

“…Antibodies of H. pylori infection and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control study within the cohort. The study included 481,419 individuals and 444 incident cases of GC that occurred during an average of 8.7 years of followup. …”

Hepcidin levels and gastric cancer risk in the EPIC-EurGast Study by Jakszyn, P, Fonseca-Nunes, A, Lujan-Barroso, L, Aranda, N, Tous, M, Arija, V, Cross, A, de Mesquita, B, Weiderpass, E, Kühn, T, Kaaks, R, Sjöberg, K, Ohlsson, B, Tumino, R, Palli, D, Ricceri, F, Fasanelli, F, Krogh, V, Mattiello, A, Jenab, M, Gunter, M, Perez-Cornago, A, Khaw, KT, Tjønneland, A, Olsen, A, Overvad, K, Trichopoulou, A, Peppa, E, Vasilopoulou, E, Boeing, H, Sánchez-Cantalejo, E, Huerta, JM, Dorronsoro, M, Barricarte, A, Quirós, JM, Peeters, PH, Agudo, A

“…To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Adiposity, mediating biomarkers and risk of colon cancer in the European prospective investigation into cancer and nutrition study. by Aleksandrova, K, Drogan, D, Boeing, H, Jenab, M, Bas Bueno-de-Mesquita, H, Jansen, E, van Duijnhoven, F, Rinaldi, S, Fedirko, V, Romieu, I, Kaaks, R, Riboli, E, Gunter, M, Romaguera, D, Westhpal, S, Overvad, K, Tjønneland, A, Halkjaer, J, Boutron-Ruault, M, Clavel-Chapelon, F, Lukanova, A, Trichopoulou, A, Trichopoulos, D, Vidalis, P, Panico, S

“…We analyzed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk sets to 662 controls. …”

The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer an... by Vollset, SE, Igland, J, Jenab, M, Fredriksen, A, Meyer, K, Eussen, S, Gjessing, H, Ueland, P, Pera, G, Sala, N, Agudo, A, Capella, G, Del Giudice, G, Palli, D, Boeing, H, Weikert, C, Bueno-de-Mesquita, H, Carneiro, F, Pala, V, Vineis, P, Tumino, R, Panico, S, Berglund, G, Manjer, J, Stenling, R

“…Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. …”