CCL5-Secreting Virtual Memory CD8+ T Cells Inversely Associate With Viral Reservoir Size in HIV‐1−Infected Individuals on Antiretroviral Therapy by Wei Hu, Wei Hu, Yan-Jun Li, Cheng Zhen, You-Yuan Wang, You-Yuan Wang, Hui-Huang Huang, Jun Zou, Yan-Qing Zheng, Gui-Chan Huang, Si-Run Meng, Jie-Hua Jin, Jing Li, Ming-Ju Zhou, Yu-Long Fu, Peng Zhang, Xiao-Yu Li, Tao Yang, Xiu-Wen Wang, Xiu-Han Yang, Jin-Wen Song, Xing Fan, Yan-Mei Jiao, Ruo-Nan Xu, Ji-Yuan Zhang, Chun-Bao Zhou, Jin-Hong Yuan, Lei Huang, Ya-Qin Qin, Feng-Yao Wu, Ming Shi, Fu-Sheng Wang, Fu-Sheng Wang, Fu-Sheng Wang, Chao Zhang, Chao Zhang

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Elevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy by You-Yuan Wang, Cheng Zhen, Wei Hu, Hui-Huang Huang, Yan-Jun Li, Ming-Ju Zhou, Jing Li, Yu-Long Fu, Peng Zhang, Xiao-Yu Li, Tao Yang, Jin-Wen Song, Xing Fan, Jun Zou, Si-Run Meng, Ya-Qin Qin, Yan-Mei Jiao, Ruonan Xu, Ji-Yuan Zhang, Chun-Bao Zhou, Jin-Hong Yuan, Lei Huang, Ming Shi, Liang Cheng, Fu-Sheng Wang, Chao Zhang

“…Single-cell metabolic modeling reveals glutamate metabolism is surprisingly robust in virtual memory CD8 + T cells (TVM). We further confirmed that glutamate inhibits TVM cells function via the mTORC1 pathway in vitro. …”
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