Single-molecule characterization of subtype-specific β1 integrin mechanics by Myung Hyun Jo, Jing Li, Valentin Jaumouillé, Yuxin Hao, Jessica Coppola, Jiabin Yan, Clare M. Waterman, Timothy A. Springer, Taekjip Ha

“…Integrins come in subtypes that bind distinct ligands. …”
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Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells by Meixuan Lin, Xiaoqiang Xu, Xiaoman Zhou, Hui Feng, Ruili Wang, Yunyun Yang, Jing Li, Ning Fan, Yazhuo Jiang, Xiang Li, Feng Guan, Zengqi Tan

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Low-affinity integrin states have faster ligand-binding kinetics than the high-affinity state by Jing Li, Jiabin Yan, Timothy A Springer

Subjects: “…integrin α4β1…”
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Novel RGD-containing peptides exhibited improved abilities to integrin receptor binding and cultures of human induced pluripotent stem cells by Ping Zhou, Fang Feng, Yameng Song, Jing Li, Qin Li, Zerong Xu, Jiamin Shi, Liying Qin, Fei He, Hongjiao Li, Yu Han, Rongzhi Zhang, Huanxiang Liu, Feng Lan

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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8 by Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Poulson, Garrett E. Casper, Mary L. Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C. Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M. Chow, Max R. Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K. Finch, David Lowe, Asim K. Bera, Gustavo Matute-Bello, Timothy P. Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R. Cochran, Lance J. Stewart, Melody G. Campbell, Pam M. Van Ry, Timothy Springer, David Baker

“…Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated cancer and fibrosis targets of considerable therapeutic importance. …”
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Mechanosensitive Piezo1 channels mediate renal fibrosis by Xiaoduo Zhao, Yonglun Kong, Baien Liang, Jinhai Xu, Yu Lin, Nan Zhou, Jing Li, Bin Jiang, Jianding Cheng, Chunling Li, Weidong Wang

“…Activation of Piezo1 by Yoda1, a Piezo1 agonist, caused calcium influx and profibrotic responses in HK2 cells and induced calcium-dependent protease calpain2 activation, followed by adhesion complex protein talin1 cleavage and upregulation of integrin β1. Also, Yoda1 promoted the link between ECM and integrin β1. …”
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An SNX31 variant underlies dominant familial exudative vitreoretinopathy-like pathogenesis by Ningda Xu, Yi Cai, Jiarui Li, Tianchang Tao, Caifei Liu, Yan Shen, Xiaoxin Li, Leiliang Zhang, Mingwei Zhao, Xuan Shi, Jing Li, Lvzhen Huang

“…We studied the biochemical mechanism of this mutation and determined that it is deficient in β1-integrin binding and stability. The SNX31 c.963delG point mutation mouse model (SNX31m/m) was constructed with CRISPR/Cas9 technology. …”
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Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease by Min Tang, Yan Jiang, Haoyu Jia, Bhuvanesh Kinish Patpur, Bo Yang, Jing Li, Changqing Yang

“…Besides, secreted OPN inhibited autophagosome-lysosome fusion via binding with its receptors integrin αVβ3 and αVβ5 in HepG2 cells supplemented with free fatty acids (FFA) and the livers of NAFLD mice. …”
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SuPAR mediates viral response proteinuria by rapidly changing podocyte function by Changli Wei, Prasun K. Datta, Florian Siegerist, Jing Li, Sudhini Yashwanth, Kwi Hye Koh, Nicholas W. Kriho, Anis Ismail, Shengyuan Luo, Tracy Fischer, Kyle T. Amber, David Cimbaluk, Alan Landay, Nicole Endlich, Jay Rappaport, Michigan Medicine COVID−19 Investigators, Salim S. Hayek, Jochen Reiser

“…In a cohort of 1991 COVID-19 patients, suPAR levels exhibit a stepwise association with proteinuria in non-Omicron, but not in Omicron infections, supporting our findings of biophysical and functional differences between variants of SARS-CoV-2 spike S1 protein and their binding to podocyte integrins. These insights are not limited to SARS-CoV-2 and define viral response proteinuria (VRP) as an innate immune mechanism and co-activation of podocyte integrins.…”
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