Mechanisms of Immunosuppression in Colorectal Cancer by Yang Zhang, Ashwani Rajput, Ning Jin, Jing Wang

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Immunosuppressive environment in response to androgen deprivation treatment in prostate cancer by Caipeng Qin, Jing Wang, Yiqing Du, Tao Xu

“…To validated the single-cell analysis we use another group of patients receiving neoadjuvant ADT.ResultsAfter receiving ADT treatment, the killing effect of prostate cancer immune cells on tumors is weakened, the interaction between immune cells and tumor cells is weakened, and the proportion of immunosuppressive cells Myeloid-derived suppressor cell (MDSC) and Regulatory T cells (Treg) cells increases.ConclusionsOur results highlight that ADT induces immunosuppressive in the prostate tumor microenvironment. …”
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Myeloid cell reprogramming alleviates immunosuppression and promotes clearance of metastatic lesions by Ravi M. Raghani, Jeffrey A. Ma, Yining Zhang, Sophia M. Orbach, Jing Wang, Mina Zeinali, Sunitha Nagrath, Sandeep Kakade, Qichen Xu, Joseph R. Podojil, Joseph R. Podojil, Tushar Murthy, Adam Elhofy, Jacqueline S. Jeruss, Jacqueline S. Jeruss, Jacqueline S. Jeruss, Lonnie D. Shea, Lonnie D. Shea

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Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis by Jingying Zhou, Huanyu Wang, Ting Shu, Jing Wang, Weiqin Yang, Jingqing Li, Lipeng Ding, Man Liu, Hanyong Sun, John Wong, Paul Bo-san Lai, Shun-Wa Tsang, Simon E. Ward, King-Lau Chow, Joseph Jao-yiu Sung, Alfred Sze-Lok Cheng

“…Taken together, our findings unravel mechanistic insights into MDSC-mediated immunosuppression and offer a therapeutic kinase-target for cancer immunotherapy.…”
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Targeting tumor immunosuppressive microenvironment for pancreatic cancer immunotherapy: Current research and future perspective by Ying Li, Shuai Xiang, Wenjun Pan, Jing Wang, Hanxiang Zhan, Shanglong Liu

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The therapeutic mechanism of Chebulae Fructus in the treatment of immunosuppression in Chinese yellow quail on the basis of network pharmacology by Qiang Wu, Min He, Jing Wang, TieJin Tong, Dan Yang, Huaqiao Tang

Subjects: “…immunosuppression…”
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An immune-related prognostic gene ULBP2 is correlated with immunosuppressive tumor microenvironment and immunotherapy in breast cancer by Rui Feng, Jiali Xu, Jing Huang, Jiazhou Liu, Xiaoyu Wang, Jing Wang, Chong Zhang, Hongzhong Li, Yuxian Wei, Guosheng Ren

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Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance by B. Leticia Rodriguez, Limo Chen, Yanli Li, Yanli Li, Shucheng Miao, Shucheng Miao, David H. Peng, Jared J. Fradette, Lixia Diao, Jessica M. Konen, Frank R. Rojas Alvarez, Luisa M. Solis, Xiaohui Yi, Xiaohui Yi, Aparna Padhye, Aparna Padhye, Laura A. Gibson, Joshua K. Ochieng, Xiaofei Zhou, Jing Wang, Don L. Gibbons, Don L. Gibbons

“…Upon extended treatment with anti-PD-1/CTLA-4 acquired resistance developed with an increase of the immunosuppressive populations, including T-regulatory cells, neutrophils and monocytes. …”
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Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin by Zhenzhen Deng, Suo Qishan, Quanbin Zhang, Jing Wang, Yang Yue, Lihua Geng, Ning Wu

“…However, the dense interstitial and immunosuppressive microenvironment frequently render the ineffective anti-tumor activity of chemotherapeutic agents. …”
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Development and validation of a combined hypoxia and ferroptosis prognostic signature for breast cancer by Jianxin Zhong, Xi Shen, Junjie Zhou, Heping Yu, Birong Wang, Jianbin Sun, Jing Wang, Feng Liu

“…Moreover, high HFRS was associated with high hypoxia, ferroptosis, and immunosuppression status. A nomogram that was constructed with age, stage, and HFRS signature showed a strong prognostic capability to predict overall survival (OS) for BC patients.ConclusionWe developed a novel prognostic model with hypoxia and ferroptosis-related genes to predict OS, and characterize the immune microenvironment of BC patients, which might provide new cures for clinical decision-making and individual treatment of BC patients.…”
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Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy by Rama Soundararajan, Jared J. Fradette, Jessica M. Konen, Stacy Moulder, Xiang Zhang, Don L. Gibbons, Navin Varadarajan, Ignacio I. Wistuba, Debasish Tripathy, Chantale Bernatchez, Lauren A. Byers, Jeffrey T. Chang, Alejandro Contreras, Bora Lim, Edwin Roger Parra, Emily B. Roarty, Jing Wang, Fei Yang, Michelle Barton, Jeffrey M. Rosen, Sendurai A. Mani

“…In addition, the EMT transition in both these cancers plays a crucial role in immunosuppression, which exacerbates treatment resistance. …”
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Mutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma by Yewen Shi, Tongxin Xie, Bingbing Wang, Rong Wang, Yu Cai, Bo Yuan, Frederico O. Gleber-Netto, Xiangjun Tian, Alanis E. Rodriguez-Rosario, Abdullah A. Osman, Jing Wang, Curtis R. Pickering, Xiaoyong Ren, Andrew G. Sikora, Jeffrey N. Myers, Roberto Rangel

“…T122N amino acid change of Tp53 promotes a cold TME enriched with immunosuppressive M2 macrophages resistant to ICI therapy.…”
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Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma by Jing Wang, Wencai Ma, Ping Yang, Tracy W Liu, Seth T Gammon, David Piwnica-Worms

“…Background The presence of a highly immunosuppressive tumor microenvironment has limited the success of immune checkpoint therapy (ICT). …”
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Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti–PD-1 resistance in non–small cell lung cancer by Jessica M. Konen, B. Leticia Rodriguez, Haoyi Wu, Jared J. Fradette, Laura Gibson, Lixia Diao, Jing Wang, Stephanie Schmidt, Ignacio I. Wistuba, Jianjun Zhang, Don L. Gibbons

“…These data reveal the ATX/LPA axis as an immunosuppressive pathway that diminishes the immune checkpoint blockade response in lung cancer.…”
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The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens by Peikun Wang, Jing Wang, Na Wang, Cong Xue, Zhaoqing Han

“…These findings demonstrated that ALV coinfection resulted in considerably severe pathogenic and immunosuppressive consequences.…”
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Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response by Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Qi Wang, Ximing Tang, Sen Pathak, Maria Gabriela Raso, Jared K. Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou

“…Consequently, GOF mutp53-MCMs-CIN-cytosolic DNA-cGAS-STING-NC-NF-κB signaling promotes tumor cell metastasis and an immunosuppressive tumor microenvironment through antagonizing interferon signaling and regulating genes associated with pro-tumorigenic inflammation. …”
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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity by Lin Hu, Fuxian Chen, Chao Wu, Jun Wang, Si-si Chen, Xiang-rong Li, Jing Wang, Linpeng Wu, Jian-ping Ding, Jian-chuan Wang, Chao Huang, Hui Zheng, Yu Rao, Yu Sun, Zhijie Chang, Wei Deng, Cheng Luo, Y. Eugene Chin

“…The FKBP12-mTOR association can be strengthened by the immunosuppressant rapamycin, but the underlying mechanism remains elusive. …”
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Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis by Xiangkun Wu, Hong Yan, Mingxing Qiu, Xiaoping Qu, Jing Wang, Shaowan Xu, Yiran Zheng, Minghui Ge, Linlin Yan, Li Liang

“…CRC samples were classified into four CCCRC subtypes with distinct TME features, namely, C1 as the proliferative subtype with low immunogenicity; C2 as the immunosuppressed subtype with the terminally exhausted immune characteristics; C3 as the immune-excluded subtype with the distinct upregulation of stromal components and a lack of T cell infiltration in the tumor core; and C4 as the immunomodulatory subtype with the remarkable upregulation of anti-tumor immune components. …”
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Endopeptidase O promotes Streptococcus suis immune evasion by cleaving the host- defence peptide cathelicidins by Mingjie Jin, Siyu Liang, Jing Wang, Huihui Zhang, Yueling Zhang, Wanjiang Zhang, Siguo Liu, Fang Xie

“…Our findings demonstrate that S. suis utilizes the PepO protease to cleave cathelicidins, which is an immunosuppressive strategy adopted by this bacterium to facilitate pathogenesis.…”
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Rapamycin Treatment Alleviates Chronic GVHD-Induced Lupus Nephritis in Mice by Recovering IL-2 Production and Regulatory T Cells While Inhibiting Effector T Cells Activation by Jilu Zhang, Xun Wang, Renxi Wang, Guojiang Chen, Jing Wang, Jiannan Feng, Yan Li, Zuyin Yu, He Xiao

“…Our studies demonstrated that, unlike other commonly used immunosuppressants, rapamycin does not appear to interfere with tolerance induction but permits the expansion and suppressive function of Tregs in vivo.…”
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