Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice by Jing Zhang, Deepti Sharma, Aumreetam Dinabandhu, Jaron Sanchez, Brooks Applewhite, Kathleen Jee, Monika Deshpande, Miguel Flores-Bellver, Ming-Wen Hu, Chuanyu Guo, Shaima Salman, Yousang Hwang, Nicole M. Anders, Michelle A. Rudek, Jiang Qian, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner, Akrit Sodhi

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Therapeutic angiogenesis and tissue revascularization in ischemic vascular disease by Xinyue Chen, Wenlu Yu, Jing Zhang, Xiao Fan, Xiao Liu, Qi Liu, Su Pan, Richard A. F. Dixon, Pengyang Li, Peng Yu, Ao Shi

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Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics by Wenhui Hu, Xuan Yao, Yuheng Li, Jianmei Li, Jing Zhang, Zhi Zou, Fei Kang, Shiwu Dong

“…Although selenium is indispensable role in the antioxidant process, the narrow therapeutic window, delicate toxicity margins, and lack of an efficient delivery system have hindered its translation to clinical applications. …”
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Neuronal activity and remyelination: new insights into the molecular mechanisms and therapeutic advancements by Yiting Zhou, Jing Zhang

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Lipid metabolism in type 1 diabetes mellitus: Pathogenetic and therapeutic implications by Jing Zhang, Yang Xiao, Jingyi Hu, Shanshan Liu, Zhiguang Zhou, Lingxiang Xie

“…This review systematically recapitulates the role and mechanisms of various lipids in T1DM, providing new therapeutic approaches for T1DM from a nutritional perspective.…”
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Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer by Jing Zhang, Doug W. Chan, Shiaw-Yih Lin

“…This intrinsic vulnerability provides a great opportunity for therapeutic exploitation. An increasing number of drug candidates targeting RS in breast cancer are demonstrating promising efficacy in preclinical and early clinical trials. …”
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The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential by Jing Zhang, Jing Zhang, Lanlan Zhang, Yutian Chen, Xiaobin Fang, Bo Li, Chunheng Mo

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Use of non‐canonical amino acids in genetic code expansion‐based therapeutics: Effects on mouse gut microbiota by Manyu Liang, Yanhong Yang, Jing Zhang, Yingjie Sun, Haixia Peng, Huawei Yi, Qin Wang, Xiaowei Gao

“…Abstract Vaccines and cell therapeutics based on genetic code expansion are emerging. …”
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B-cell targeted therapies in autoimmune encephalitis: mechanisms, clinical applications, and therapeutic potential by Haodong Shang, Haodong Shang, Xinru Shen, Xinru Shen, Xiaoxiao Yu, Xiaoxiao Yu, Jing Zhang, Jing Zhang, Yongliang Jia, Yongliang Jia, Feng Gao, Feng Gao

“…This review summarizes the mechanisms underlying these two B-cell targeted therapies and discusses their clinical applications and therapeutic potential in AE. Our research provides clinicians with more treatment options for AE patients whose conventional treatments are not effective.…”
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The regulation of circRNA and lncRNAprotein binding in cardiovascular diseases: Emerging therapeutic targets by Huilei Zhao, Ziqi Tan, Jin Zhou, Yifan Wu, Qingwen Hu, Qing Ling, Jitao Ling, Menglu Liu, Jianyong Ma, Deju Zhang, Yue Wang, Jing Zhang, Peng Yu, Yuan Jiang, Xiao Liu

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Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy by Jing Zhang, Jian Bai, Chen Gong, Jianhua Wang, Yi Cheng, Jing Zhao, Huihua Xiong

“…Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies.…”
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Ten-eleven translocation-2 affects the fate of cells and has therapeutic potential in digestive tumors by Feng Wang, Jing Zhang, Jian Qi

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A Gene Expression Signature to Predict Nucleotide Excision Repair Defects and Novel Therapeutic Approaches by Rongbin Wei, Hui Dai, Jing Zhang, David J. H. Shih, Yulong Liang, Pengfeng Xiao, Daniel J. McGrail, Shiaw-Yih Lin

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Ripasudil as a Potential Therapeutic Agent in Treating Secondary Glaucoma in HTLV-1-Uveitis: An In Vitro Analysis by Mingming Yang, Koju Kamoi, Yuan Zong, Jing Zhang, Yaru Zou, Kyoko Ohno-Matsui

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Roles of N6-methyladenosine (m6A) modifications in gynecologic cancers: mechanisms and therapeutic targeting by Jiahua Chen, Bao Guo, Xiaojing Liu, Jing Zhang, Junhui Zhang, Yuan Fang, Suding Zhu, Bing Wei, Yunxia Cao, Lei Zhan

“…The m6A-related regulatory factors can also be used as therapeutic targets and biomarkers for the early diagnosis of cancers, including gynecologic cancers. …”
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A Systematic Review of the Advances in the Study of T Lymphocyte Suppressor Receptors in HBV Infection: Potential Therapeutic Targets by Daqiong Zhou, Lili Liu, Jiangyu Liu, Hong Li, Jing Zhang, Zhenhuan Cao

“…<b>Conclusions:</b> Targeting T cell suppressor receptors and combining immunotherapy with antiviral treatments may offer a promising approach towards achieving a functional cure, urging future research to prioritize effective combination therapeutic strategies for chronic HBV infection.…”
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Genomic analysis of schistosomiasis-associated colorectal cancer reveals a unique mutational landscape and therapeutic implications by Dong Yu, Anqi Wang, Jing Zhang, Xinxin Li, Caifeng Jiang, Haiyang Zhou

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Identification of two robust subclasses of sepsis with both prognostic and therapeutic values based on machine learning analysis by Wei Zhou, Chunyu Zhang, Chunyu Zhang, Zhongwei Zhuang, Jing Zhang, Jing Zhang, Chunlong Zhong, Chunlong Zhong

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Combined Transcriptomic and Proteomic Profiling of the Mouse Anterior Cingulate Cortex Identifies Potential Therapeutic Targets for Pulpitis-Induced Pain by Xiaoning Kang, Jialin Si, Jing Zhang, Xia Yan, Zhuo Yu, Yaoyuan Zhang, Xinwei Li, Li-an Wu

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Identification of GINS1 as a therapeutic target in the cancer patients infected with COVID-19: a bioinformatics and system biology approach by Changpeng Hu, Yue Dai, Huyue Zhou, Jing Zhang, Dandan Xie, Rufu Xu, Mengmeng Yang, Rong Zhang

“…Conclusion We revealed the GINS1 is a potential therapeutic target in cancer patients infected with COVID-19 for the first time, as COVID-19 will be a severe and prolonged pandemic. …”
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