Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics by Katarzyna Ciapała, Joanna Mika

“…Despite the availability of many different analgesics, relieving neuropathic pain is still extremely difficult and requires a multidirectional, individual approach. …”
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Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain by Katarzyna Ciapała, Ewelina Rojewska, Katarzyna Pawlik, Agata Ciechanowska, Joanna Mika

“…Additionally, both of the activators tested, bardoxolone methyl and 740 Y-P, also showed analgesic effects after intrathecal administration in mice exposed to CCI. …”
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New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies by Agata Ciechanowska, Ewelina Rojewska, Anna Piotrowska, Justyna Barut, Katarzyna Pawlik, Katarzyna Ciapała, Grzegorz Kreiner, Joanna Mika

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Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors by Agnieszka M. Jurga, Ewelina Rojewska, Wioletta Makuch, Joanna Mika

“…TLR4 blockade has analgesic properties and restores the balance between nociceptive factors, which indicates its engagement in neuropathy development.…”
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Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model—<i>In Vivo</i> and <i>In Vitro</i> Study by Anna Piotrowska, Katarzyna Ciapała, Katarzyna Pawlik, Klaudia Kwiatkowski, Ewelina Rojewska, Joanna Mika

“…Interestingly, NVP-CXCR2-20 induced analgesic effects after intraperitoneal administration. …”
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Mirogabalin Decreases Pain-like Behaviors by Inhibiting the Microglial/Macrophage Activation, p38MAPK Signaling, and Pronociceptive CCL2 and CCL5 Release in a Mouse Model of Neurop... by Renata Zajączkowska, Katarzyna Pawlik, Katarzyna Ciapała, Anna Piotrowska, Agata Ciechanowska, Ewelina Rojewska, Magdalena Kocot-Kępska, Wioletta Makuch, Jerzy Wordliczek, Joanna Mika

“…For that reason, looking for new analgesics remains an important issue. Mirogabalin is a new gabapentinoid that is a specific ligand for the α2σ-1 and α2σ-2 subunits of voltage-gated calcium channels. …”
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Botulinum Toxin Type A—A Modulator of Spinal Neuron–Glia Interactions under Neuropathic Pain Conditions by Ewelina Rojewska, Anna Piotrowska, Katarzyna Popiolek-Barczyk, Joanna Mika

“…Therefore, there is still a strong need for new analgesics. Botulinum neurotoxin A (BoNT/A) is used to treat a variety of clinical diseases associated with pain. …”
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Mirogabalin—A Novel Selective Ligand for the α2δ Calcium Channel Subunit by Renata Zajączkowska, Joanna Mika, Wojciech Leppert, Magdalena Kocot-Kępska, Małgorzata Malec-Milewska, Jerzy Wordliczek

“…The ligand selectivity of mirogabalin for α2δ-1 and α2δ-2 and its slower dissociation rate for α2δ-1 than for α2δ-2 subunits of VGCC may contribute to its strong analgesic effects, wide safety margin, and relatively lower incidence of adverse effects compared to pregabalin and gabapentin. …”
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The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives by Katarzyna Ciapała, Joanna Mika, Ewelina Rojewska

“…Importantly, some compounds that affect KP enzymes are currently described to possess analgesic properties. Additionally, kynurenine metabolites may be useful for assessing response to therapy or as biomarkers in therapeutic monitoring. …”
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Phenytoin Decreases Pain-like Behaviors and Improves Opioid Analgesia in a Rat Model of Neuropathic Pain by Magdalena Kocot-Kępska, Katarzyna Pawlik, Katarzyna Ciapała, Wioletta Makuch, Renata Zajączkowska, Jan Dobrogowski, Anna Przeklasa-Muszyńska, Joanna Mika

“…Neuropathic pain remains a clinical challenge due to its complex and not yet fully understood pathomechanism, which result in limited analgesic effectiveness of the management offered, particularly for patients with acute, refractory neuropathic pain states. …”
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Mirogabalin Decreases Pain-like Behaviours and Improves Opioid and Ketamine Antinociception in a Mouse Model of Neuropathic Pain by Renata Zajączkowska, Ewelina Rojewska, Agata Ciechanowska, Katarzyna Pawlik, Katarzyna Ciapała, Magdalena Kocot-Kępska, Wioletta Makuch, Jerzy Wordliczek, Joanna Mika

“…The findings of our study suggest that several indirect mechanisms may be responsible for the beneficial analgesic effect of mirogabalin. This is the first study to report that mirogabalin enhances the mRNA expression of spinal antinociceptive factors, such as IL-10 and IL-18BP, and reduces the concentration of the pronociceptive substance P. …”
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Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain by Katarzyna Pawlik, Joanna Mika

“…Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients’ quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. …”
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CC Chemokine Family Members’ Modulation as a Novel Approach for Treating Central Nervous System and Peripheral Nervous System Injury—A Review of Clinical and Experimental Findings... by Agata Ciechanowska, Joanna Mika

“…In addition, both single (J113863, RS504393, SB328437, C021, and maraviroc) and dual (cenicriviroc) chemokine receptor antagonists enhanced the analgesic effect of opioid drugs. This review will display the evidence that a multidirectional strategy based on the modulation of neuronal–glial–immune interactions can significantly improve the health of patients after CNS and PNS damage by changing the activity of chemokines belonging to the CC family. …”
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Peripheral Mechanisms of Neuropathic Pain—The Role of Neuronal and Non-Neuronal Interactions and Their Implications for Topical Treatment of Neuropathic Pain by Magdalena Kocot-Kępska, Renata Zajączkowska, Joanna Mika, Jerzy Wordliczek, Jan Dobrogowski, Anna Przeklasa-Muszyńska

“…The modulation of the complex neuro-immuno-cutaneous interactions in the periphery represents a strategy for the development of new topical analgesics and their utilization in clinical settings.…”
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