Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models by Jinny Sun, Robert A. Bok, Justin DeLos Santos, Deepti Upadhyay, Romelyn DeLos Santos, Shubhangi Agarwal, Mark Van Criekinge, Daniel B. Vigneron, Rahul Aggarwal, Donna M. Peehl, John Kurhanewicz, Renuka Sriram

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The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized ¹³C MRSI by Robert Bok, Jessie Lee, Renuka Sriram, Kayvan Keshari, Subramaniam Sukumar, Saeed Daneshmandi, David E. Korenchan, Robert R. Flavell, Daniel B. Vigneron, John Kurhanewicz, Pankaj Seth

“…This study applied a dual-agent, ¹³C-pyruvate and ¹³C-urea, hyperpolarized ¹³C magnetic resonance spectroscopic imaging (MRSI) and multi-parametric (mp) ¹H magnetic resonance imaging (MRI) approach in the transgenic adenocarcinoma of mouse prostate (TRAMP) model to investigate changes in tumor perfusion and lactate metabolism during prostate cancer development, progression and metastases, and after lactate dehydrogenase-A (LDHA) knock-out. …”
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