Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma by Jie Chen, Chaofeng Xing, Li Yan, Yabing Wang, Haosen Wang, Zongmeng Zhang, Daolun Yu, Jie Li, Honglin Li, Jun Li, Yafei Cai

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Chemerin deficiency regulates adipogenesis is depot different through TIMP1 by Cheng-Long Huang, Liu-Ling Xiao, Min Xu, Jun Li, Shu-Fen Li, Cui-Song Zhu, Yu-Li Lin, Rui He, Xi Li

“…The present study demonstrates that the effects of chemerin on adipose tissue is depot different, and specific knock down chemerin in SAT promote adipogenesis and improve glucose tolerance test (GTT) and insulin tolerance test (ITT). …”
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Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis by Alia M. Obeidat, Matthew J. Wood, Natalie S. Adamczyk, Shingo Ishihara, Jun Li, Lai Wang, Dongjun Ren, David A. Bennett, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller

“…Here we show that nociceptor-specific Piezo2 conditional knock-out mice were protected from mechanical sensitization associated with inflammatory joint pain in female mice, joint pain associated with osteoarthritis in male mice, as well as both knee swelling and joint pain associated with repeated intra-articular injection of nerve growth factor in male mice. …”
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A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models by Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jianming Wang, Jun Li, Xiaohui Sun, Yiming Zhu, Zhaohui Feng, Wenwei Hu

“…Here, employing a mouse model with knock-in of human TP53 gene carrying codon 72 SNP, we found that despite increased cancer risk, P72 mice that escape tumor development display a longer lifespan than R72 mice. …”
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TRIB3 promotes the progression of renal cell carcinoma by upregulating the lipid droplet-associated protein PLIN2 by Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Huikun Chen, Haiyun Xiong, Yiyu Sheng, Xianju Chen, Jun Pang

“…TRIB3 overexpression was observed in both RCC patient tumor tissues and cell lines, and this upregulation was correlated with a worse RCC patient prognosis. When TRIB3 was knocked down, this resulted in a reduction in lipid accumulation and the consequent induction of endoplasmic reticulum (ER) stress-related apoptotic cell death. …”
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MACF1 overexpression in BMSCs alleviates senile osteoporosis in mice through TCF4/miR-335–5p signaling pathway by Kewen Zhang, Wuxia Qiu, Hui Li, Jun Li, Pai Wang, Zhihao Chen, Xiao Lin, Airong Qian

“…Methods: We established MSC-specific Prrx1 (Prx1) promoter-driven MACF1 conditional knock-in (MACF-KI) mice, naturally aged male mice, and ovariectomized female mice models. …”
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HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1 by Hang You, Guojing Song, Zhizhen Xu, Saipeng Chen, Wenhao Shen, Heting Liu, Bingqian Deng, Jun Li, Gang Huang

“…This study aimed to clarify the role and mechanism of Human antigen R (HuR) as a therapeutic target for CRPC progression. Methods HuR was knocked out by Cas9 or inhibited by the HuR-specific inhibitor KH-3 in CRPC cell lines and in a mouse xenograft model. …”
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PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation by Changlin Du, Chuanting Xu, Pengcheng Jia, Na Cai, Zhenming Zhang, Wenna Meng, Lu Chen, Zhongnan Zhou, Qi Wang, Rui Feng, Jun Li, Xiaoming Meng, Cheng Huang, Taotao Ma

“…We found that renal tubular epithelial cell (RTEC) apoptosis, neutrophil infiltration, inflammatory factor, and NET production were increased in a mouse model of AAN, while PSTPIP2 expression was low. Conditional knock-in of Pstpip2 in mouse kidneys inhibited cell apoptosis, reduced neutrophil infiltration, suppressed the production of inflammatory factors and NETs, and ameliorated renal dysfunction. …”
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RNAi-Mediated Silencing of Putative Halloween Gene Phantom Affects the Performance of Rice Striped Stem Borer, <i>Chilo suppressalis</i> by Muhammad Faisal Shahzad, Atif Idrees, Ayesha Afzal, Jamshaid Iqbal, Ziyad Abdul Qadir, Azhar Abbas Khan, Ayat Ullah, Jun Li

“…Double-stranded RNA (dsRNA) injection of Cs-Phm at the larval stage efficiently knocked down the target gene and decreased its expression level. …”
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CRISPR/Cas9-mediated knockout of the Vanin-1 gene in the Leghorn Male Hepatoma cell line and its effects on lipid metabolism by Lu Xu, Zhongliang Wang, Shihao Liu, Zhiheng Wei, Jianfeng Yu, Jun Li, Jie Li, Wen Yao, Zhiliang Gu

“…Methods First, we detected the VNN1 mRNA expression in 4-week chickens which were fasted 24 hours. Next, knocked out VNN1 via CRISPR/Cas9 system in the chicken Leghorn Male Hepatoma cell line. …”
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