EGFR as a Negative Regulatory Protein Adjusts the Activity and Mobility of NHE3 in the Cell Membrane of IPEC-J2 Cells With TGEV Infection by Zhou Yang, Ling Ran, Peng Yuan, Yang Yang, Kai Wang, Luyi Xie, Shilei Huang, Jia Liu, Zhenhui Song

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Preliminary Study of Resistance Mechanism of <i>Botrytis cinerea</i> to SYAUP-CN-26 by Kai Wang, Huazhong Zhang, Wanying Zhu, Jingnan Peng, Xinghai Li, Yingzi Wang, Zhiqiu Qi

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Immunomodulatory role of metalloproteinase ADAM17 in tumor development by Kai Wang, Zixue Xuan, Xiaoyan Liu, Meiling Zheng, Chao Yang, Haiyong Wang

“…ADAM17 is a member of the a disintegrin and metalloproteinase (ADAM) family of transmembrane proteases involved in the shedding of some cell membrane proteins and regulating various signaling pathways. …”
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Physiological and Biochemical Responses of <i>Sagittaria trifolia</i> L. to Phytotoxic Ethyl Acetate Fungal Extract from <i>Curvularia lunata</i> Strain CLST-01 by Kai Wang, Chang Xu, Dongyang Li, Zumin Gu

“…The results showed that the ethyl acetate fungi extract from CLST-01 can accelerate damage to the cell membrane, increase the production of malondialdehyde, and damage the cellular structure, which could decrease the number of chloroplasts after 96 h treatments. …”
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Ferroptosis and its emerging role in esophageal cancer by Rezeye Maimaitizunong, Kai Wang, Hui Li

“…Ferroptosis is a non-apoptotic form of cell death, which is characterized by lipid peroxidation accumulation and further cell membrane rupture caused by excessive production of intracellular oxygen free radicals dependent on iron ions. …”
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Silencing of human phosphatidylethanolamine-binding protein 4 enhances rituximab-induced death and chemosensitization in B-cell lymphoma. by Kai Wang, Yu Jiang, Weiyan Zheng, Zhiyong Liu, Hui Li, Jianzhou Lou, Meidi Gu, Xiaojian Wang

“…During rituximab-mediated complement dependent cytotoxicity, hPEBP4 was recruited to the cell membrane in a PE-binding domain dependent manner and inhibited R-CDC induced calcium flux and reactive oxygen species (ROS) generation. …”
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Vegetative cell wall protein OsGP1 regulates cell wall mediated soda saline-alkali stress in rice by Fengjin Zhu, Huihui Cheng, Jianan Guo, Shuomeng Bai, Ziang Liu, Chunxi Huang, Jiayi Shen, Kai Wang, Chengjun Yang, Qingjie Guan

“…OsGP1 was found to be localized in the cell membrane and cell wall. Furthermore, overexpression of OsGP1 leads to increase in plant height and fresh weight, showing enhanced resistance to saline-alkali stress. …”
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Antibacterial Activity of Chinese Red Propolis against <i>Staphylococcus aureus</i> and MRSA by Wenwen Zhang, Gomez Escalada Margarita, Di Wu, Wenqin Yuan, Sha Yan, Suzhen Qi, Xiaofeng Xue, Kai Wang, Liming Wu

“…In vitro investigations of its antibacterial activity revealed that its activity against <i>S. aureus</i> and MRSA is due to disruption of the cell wall and cell membrane, which then inhibits bacterial growth. …”
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Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma by Youmei Xiao, Zhanxue Xu, Yuan Cheng, Rufan Huang, Yuan Xie, Hsiang-i Tsai, Hualian Zha, Lifang Xi, Kai Wang, Xiaoli Cheng, Yanfeng Gao, Changhua Zhang, Fang Cheng, Hongbo Chen

“…Methods To further verify the biological targets associated with ferroptosis in HCC, an analysis of the Cancer Genome Atlas (TCGA) database was performed to find a significant co-upregulation of SLC7A11 and transferrin receptor (TFRC), Herein, cell membrane-derived transferrin nanovesicles (TF NVs) coupled with Fe3+ and encapsulated SOR (SOR@TF-Fe3+ NVs) were established to synergistically promote ferroptosis, which promoted the iron transport metabolism by TFRC/TF-Fe3+ and enhanced SOR efficacy by inhibiting the SLC7A11. …”
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αvβ3-targeted sEVs for efficient intracellular delivery of proteins using MFG-E8 by Junxin Mai, Kai Wang, Chenxuexuan Liu, Sheng Xiong, Qiuling Xie

“…Firstly, we transiently expressed MFG-E8 in HEK293F cells and found that this protein could be secreted and adhere to the cell membrane. The recombinant MFG-E8 is also found to locate at the outer membrane of sEVs. …”
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Transcriptome, proteome and functional characterization reveals salt stress tolerance mechanisms in upland cotton (Gossypium hirsutum L.) by Kangtai Sun, Kangtai Sun, Teame Gereziher Mehari, Hui Fang, Jinlei Han, Xuehan Huo, Jingxia Zhang, Yu Chen, Dongmei Wang, Zhimin Zhuang, Allah Ditta, Muhammad K.R. Khan, Jun Zhang, Kai Wang, Baohua Wang

“…GO enrichment was carried out mainly in the cell membrane, organelle, cellular process, metabolic process, and stress response. …”
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Identification of common fungal extracellular membrane (CFEM) proteins in Fusarium sacchari that inhibit plant immunity and contribute to virulence by Zhen Huang, Yuming Zhou, Huixue Li, Yixue Bao, Zhenzhen Duan, Caixia Wang, Charles A. Powell, Kai Wang, Qin Hu, Baoshan Chen, Jisen Zhang, Muqing Zhang, Wei Yao

“…Subcellular localization analysis revealed that these four effectors could enter plant cells and are mainly located in the cell membrane and nucleus. By the yeast YTK12 secretion system, the signal peptides of four CFEM proteins were functionally verified. …”
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The Analogs of Furanyl Methylidene Rhodanine Exhibit Broad-Spectrum Inhibitory and Inactivating Activities against Enveloped Viruses, including SARS-CoV-2 and Its Variants by Jing Pu, Xiaoyang He, Wei Xu, Cong Wang, Qiaoshuai Lan, Chen Hua, Kai Wang, Lu Lu, Shibo Jiang

“…Further studies have shown that these compounds may exert antiviral effects through a variety of mechanisms, including inhibiting the formation of the six-helix bundle, which is a typical feature of enveloped virus fusion with cell membranes, and/or targeting viral membrane to inactivate cell-free virions. …”
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