Biological Mechanism(s) Underpinning the Association between Antipsychotic Drugs and Weight Gain by Bruna Panizzutti, Chiara C. Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Timothy Connor, Mark F. Richardson, Trang T. T. Truong, Zoe S. J. Liu, Laura Gray, Jee Hyun Kim, Olivia M. Dean, Michael Berk, Ken Walder

“…The list of genes involved in the lipid pathways that correlated with weight gain was enriched for genes transcriptionally regulated by <i>SREBF1</i> and <i>SREBF2</i>. Furthermore, quetiapine significantly increased the expression of <i>SREBF1</i> and <i>SREBF2</i> in NT-2 cells. …”
Get full text

Transcriptional Effects of Psychoactive Drugs on Genes Involved in Neurogenesis by Chiara C. Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Timothy Connor, Trang T.T. Truong, Zoe S.J. Liu, Bruna Panizzutti, Mark F. Richardson, Laura Gray, Michael Berk, Olivia M. Dean, Ken Walder

“…Neuronal-like cells (NT2-N) were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), or valproate (0.5 mM) for 24 h. …”
Get full text

Transcriptional Modulation of the Hippo Signaling Pathway by Drugs Used to Treat Bipolar Disorder and Schizophrenia by Bruna Panizzutti, Chiara C. Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Timothy Connor, Mark F. Richardson, Trang T. T. Truong, Zoe S. J. Liu, Gerwyn Morris, Laura Gray, Jee Hyun Kim, Olivia M. Dean, Michael Berk, Ken Walder

“…In this study, neuronal-like NT2 cells were treated with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM), or vehicle control for 24 h. …”
Get full text

Effects of Psychotropic Drugs on Ribosomal Genes and Protein Synthesis by Zoe S. J. Liu, Trang T. T. Truong, Chiara C. Bortolasci, Briana Spolding, Bruna Panizzutti, Courtney Swinton, Jee Hyun Kim, Srisaiyini Kidnapillai, Mark F. Richardson, Laura Gray, Olivia M. Dean, Sean L. McGee, Michael Berk, Ken Walder

“…We treated human neuronal-like (NT2-N) cells with amisulpride (10 µM), aripiprazole (0.1 µM), clozapine (10 µM), lamotrigine (50 µM), lithium (2.5 mM), quetiapine (50 µM), risperidone (0.1 µM), valproate (0.5 mM) or vehicle control for 24 h. …”
Get full text