Menopausal hormone therapy and breast cancer risk: impact of different treatments. The European Prospective Investigation into Cancer and Nutrition. by Bakken, K, Fournier, A, Lund, E, Waaseth, M, Dumeaux, V, Clavel-Chapelon, F, Fabre, A, Hémon, B, Rinaldi, S, Chajes, V, Slimani, N, Allen, N, Reeves, G, Bingham, S, Khaw, K, Olsen, A, Tjønneland, A, Rodriguez, L, Sánchez, M, Etxezarreta, P, Ardanaz, E, Tormo, M, Peeters, P, Gils, v, Steffen, A

“…Menopausal hormone therapy (MHT) is characterized by use of different constituents, regimens and routes of administration. …”

Age at menopause, reproductive life span, and type 2 diabetes risk: Results from the EPIC-InterAct study by Brand, J, Van Der Schouw, Y, Onland-Moret, N, Sharp, S, Ong, K, Khaw, K, Ardanaz, E, Ardanaz, E, Amiano, P, Amiano, P, Amiano, P, Boeing, H, Chirlaque, MD, Chirlaque, MD, Clavel-Chapelon, F, Crowe, F, De Lauzon-Guillain, B, De Lauzon-Guillain, B, Duell, E, Fagherazzi, G, Fagherazzi, G, Franks, P, Franks, P, Grioni, S, Groop, L

“…We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. …”

Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study. by Brand, J, van der Schouw, Y, Onland-Moret, N, Sharp, S, Ong, K, Khaw, K, Ardanaz, E, Amiano, P, Boeing, H, Chirlaque, MD, Clavel-Chapelon, F, Crowe, F, de Lauzon-Guillain, B, Duell, E, Fagherazzi, G, Franks, P, Grioni, S, Groop, L, Kaaks, R, Key, T, Nilsson, P, Overvad, K, Palli, D, Panico, S, Quirós, JR

“…We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. …”

Relationship of alcohol intake and sex steroid concentrations in blood in pre- and post-menopausal women: The European Prospective Investigation into Cancer and Nutrition by Rinaldi, S, Peeters, P, Bezemer, I, Dossus, L, Biessy, C, Sacerdote, C, Berrino, F, Panico, S, Palli, D, Tumino, R, Khaw, K, Bingham, S, Allen, N, Key, T, Jensen, M, Overvad, K, Olsen, A, Tjonneland, A, Amiano, P, Ardanaz, E, Agudo, A, Martinez-García, C, Quirós, JR, Tormo, M, Nagel, G

“…In the present study, we investigate the relationships between alcohol consumption and serum levels of sex steroids and sex-hormone binding globulin (SHBG) in 790 pre- and 1,291 post-menopausal women, who were part of the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

An epidemiological model for prediction of endometrial cancer risk in Europe. by Hüsing, A, Dossus, L, Ferrari, P, Tjønneland, A, Hansen, L, Fagherazzi, G, Baglietto, L, Schock, H, Chang-Claude, J, Boeing, H, Steffen, A, Trichopoulou, A, Bamia, C, Katsoulis, M, Krogh, V, Palli, D, Panico, S, Onland-Moret, N, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Gram, I, Ardanaz, E, Obón-Santacana, M, Navarro, C, Sánchez-Cantalejo, E, Etxezarreta, N, Allen, N, Khaw, K, Wareham, N, Rinaldi, S, Romieu, I, Merritt, M, Gunter, M, Riboli, E, Kaaks, R

“…Risk factors included in the risk prediction model were body-mass index (BMI), menopausal status, age at menarche and at menopause, oral contraceptive use, overall and by different BMI categories and overall duration of use, parity, age at first full-term pregnancy, duration of menopausal hormone therapy and smoking status (specific for pre, peri- and post-menopausal women). …”

Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study. by Ritte, R, Tikk, K, Lukanova, A, Tjønneland, A, Olsen, A, Overvad, K, Dossus, L, Fournier, A, Clavel-Chapelon, F, Grote, V, Boeing, H, Aleksandrova, K, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Berrino, F, Mattiello, A, Tumino, R, Sacerdote, C, Quirós, JR, Buckland, G, Molina-Montes, E, Chirlaque, MD, Ardanaz, E, Amiano, P, Bueno-de-Mesquita, H, Gils, v, Peeters, P, Wareham, N, Khaw, K, Key, T, Travis, R, Weiderpass, E, Dumeaux, V, Lund, E, Sund, M, Andersson, A, Romieu, I, Rinaldi, S, Vineis, P, Merritt, M, Riboli, E, Kaaks, R

“…METHODS: Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors. …”

Dietary patterns derived with multiple methods from food diaries and breast cancer risk in the UK Dietary Cohort Consortium. by Pot, G, Stephen, A, Dahm, C, Key, T, Cairns, B, Burley, V, Cade, J, Greenwood, D, Keogh, R, Bhaniani, A, McTaggart, A, Lentjes, M, Mishra, G, Brunner, E, Khaw, K

“…A separate model was fitted for post-menopausal women only. RESULTS: The MDS was not associated with breast cancer risk (OR comparing first tertile with third 1.20 (95% CI 0.92; 1.56)), nor the first PCA-derived dietary pattern, explaining 2.7% of variation of diet and characterized by cheese, crisps and savoury snacks, legumes, nuts and seeds (OR 1.18 (95% CI 0.91; 1.53)). …”

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk by Campa, D, Hüsing, A, McKay, J, Sinilnikova, O, Vogel, U, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, N, Gils, V, Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Quirós, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, R, Key, T, Wareham, N, Khaw, K, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R, Canzian, F

“…<br/><br/> <b>Results and Conclusions:</b> In this study we were not able to find any statistically significant association between this SNP and BMI, nor did we find any significant association between the SNP and an increased risk of breast cancer overall and by subgroups of age, or menopausal status. </p> …”

Circulating insulin‐like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition by Bradbury, K, Appleby, P, Tipper, S, Travis, R, Allen, N, Kvaskoff, M, Overvad, K, Tjønneland, A, Halkjaer, J, Cevenka, I, Mahamat-Saleh, Y, Bonnet, F, Kaaks, R, Turzanski Fortner, R, Boeing, H, Trichopoulou, A, La Vecchia, C, Stratigos, A, Palli, D, Grioni, S, Matullo, G, Panico, S, Tumino, R, Peeters, P, Bueno-De-Mesquita, B, Ghiasvand, R, Veierød, M, Weiderpass, E, Bonet, C, Molina, E, Huerta, J, Larrañaga, N, Barricarte, A, Merino, S, Isaksson, K, Stocks, T, Ljuslinder, I, Hemmingsson, O, Wareham, N, Khaw, K, Gunter, M, Rinaldi, S, Tsilidis, K, Aune, D, Riboli, E, Key, T

“…Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF‐I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). …”

Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC). by Engeset, D, Alsaker, E, Lund, E, Welch, A, Khaw, K, Clavel-Chapelon, F, Thiébaut, A, Chajès, V, Key, T, Allen, N, Amiano, P, Dorronsoro, M, Tjønneland, A, Stripp, C, Peeters, P, Gils, v, Chirlaque, MD, Nagel, G, Linseisen, J, Ocké, M, Bueno-de-Mesquita, H, Sacerdote, C, Tumino, R, Ardanaz, E, Sánchez, M

“…No associations with breast cancer risk were observed when the study participants were subdivided by menopausal status. Although the period of follow-up is relatively short, the results provide no evidence for an association between fish intake and breast cancer risk.…”

Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). by Murphy, N, Norat, T, Ferrari, P, Jenab, M, Bueno-de-Mesquita, B, Skeie, G, Dahm, C, Overvad, K, Olsen, A, Tjønneland, A, Clavel-Chapelon, F, Boutron-Ruault, M, Racine, A, Kaaks, R, Teucher, B, Boeing, H, Bergmann, M, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Palli, D, Pala, V, Panico, S, Tumino, R, Vineis, P, Siersema, P, van Duijnhoven, F, Peeters, P, Hjartaker, A, Engeset, D, González, C, Sánchez, M, Dorronsoro, M, Navarro, C, Ardanaz, E, Quirós, JR, Sonestedt, E, Ericson, U, Nilsson, L, Palmqvist, R, Khaw, K, Wareham, N, Key, T, Crowe, F, Fedirko, V, Wark, P, Chuang, S, Riboli, E

“…Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. …”

Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort. by Rinaldi, S, Key, T, Peeters, P, Lahmann, P, Lukanova, A, Dossus, L, Biessy, C, Vineis, P, Sacerdote, C, Berrino, F, Panico, S, Tumino, R, Palli, D, Nagel, G, Linseisen, J, Boeing, H, Roddam, A, Bingham, S, Khaw, K, Chloptios, J, Trichopoulou, A, Trichopoulos, D, Tehard, B, Clavel-Chapelon, F, Gonzalez, C

“…Height, weight, waist and hip circumferences, and serum measurements of testosterone [T], androstenedione [Delta4], dehydroepiandrosterone sulphate [DHEAS], estradiol [E2], estrone [E1] and sex-hormone binding globulin [SHBG] were available for 613 breast cancer cases, and 1,139 matched controls, who were all menopausal at the time of blood donation. Free T [fT] and free E2 [fE2] were calculated using mass action equations. …”

Vitamin C intake from diary recordings and risk of breast cancer in the UK Dietary Cohort Consortium. by Hutchinson, J, Lentjes, M, Greenwood, D, Burley, V, Cade, J, Cleghorn, C, Threapleton, D, Key, T, Cairns, B, Keogh, R, Dahm, C, Brunner, E, Shipley, M, Kuh, D, Mishra, G, Stephen, A, Bhaniani, A, Borgulya, G, Khaw, K

“…Additionally, there was no significant association for post-menopausal women (OR=1.02 per 60 mg/day, 95% CI: 0.99-1.05, P (trend)=0.3). …”

Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study by Buckland, G, Travier, N, Cottet, V, González, C, Luján-Barroso, L, Agudo, A, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Peeters, P, May, A, Bueno-De-Mesquita, H, Bvan Duijnhoven, F, Key, T, Allen, N, Khaw, K, Wareham, N, Romieu, I, McCormack, V, Boutron-Ruault, M, Clavel-Chapelon, F, Panico, S, Agnoli, C, Palli, D, Tumino, R

“…Many factors can affect susceptibility to breast cancer, including menopausal status and diet. This study investigated the association between breast cancer and an adapted version of the "Mediterranean diet," excluding alcohol. …”

Broadband ultrasound attenuation (BUA) of the heel bone and its correlates in men and women in the EPIC-Norfolk cohort: a cross-sectional population-based study. by Welch, A, Camus, J, Dalzell, N, Oakes, S, Reeve, J, Khaw, K

“…. -0.15 dB/MHz per year). Pre- and post-menopausal bone loss was 0.39 and 0.85 dB/MHz per year, respectively. …”