Parvovirus 4 infection and clinical outcome in high-risk populations by Simmons, R, Sharp, C, Rohrbach, J, Kovari, H, Frangou, E, Simmonds, P, Irving, W, Rauch, A, Bowness, P, Klenerman, P, Swiss HIV Cohort Study

Parvovirus 4 infection and clinical outcome in high-risk populations. by Simmons, R, Sharp, C, McClure, C, Rohrbach, J, Kovari, H, Frangou, E, Simmonds, P, Irving, W, Rauch, A, Bowness, P, Klenerman, P

Differences of the phenotype of CD4+ and CD8+ T-cell populations in Wegener's granulomatosis. by Lamprecht, P, Mueller, A, Cuero, A, Csernok, E, Voswinkel, J, Gross, W, Klenerman, P

Population analysis of antiviral T cell responses using MHC class I-peptide tetramers. by Komatsu, H, Sierro, S, V Cuero, A, Klenerman, P

“…These data show that tetramers can be used as population screening tools and could be used to study age-related, geographical or seasonal effects in a number of other viral infections.…”

Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis. by Lamprecht, P, Vargas Cuero, A, Muller, A, Csernok, E, Voswinkel, J, Maass, M, Solbach, W, Gross, W, Klenerman, P

Real-time seroprevalence and exposure levels of emerging pathogens in infection-naive host populations by Pinotti, F, Obolski, U, Wikramaratna, P, Giovanetti, M, Paton, R, Klenerman, P, Thompson, C, Gupta, S, Lourenço, J

“…These results contribute to a better understanding and interpretation of real-time serological data collected during the emergence of pathogens in infection-naive host populations.…”

Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection. by Sierro, S, Rothkopf, R, Klenerman, P

“…We analyzed the extent to which such responses differ functionally and tracked both their population distribution and their evolution over time. …”

A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro. by Ehl, S, Klenerman, P, Aichele, P, Hengartner, H, Zinkernagel, R

“…When the function of various cell populations was compared in this model, we found that CTL from naive and memory mice perform considerably less well than CTL from acutely infected mice. …”

A novel subset of anti-viral T cells: the CD161dim CD8(+) population by Fergusson, JR, Ussher, J, Newell, E, Klenerman, P

Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population by Allain, J, Chuang, W, Sarkodie, F, Brown, C, Owusu-Ofori, S, Brown, J, Navarrete, C, Klenerman, P

Development of a virus immunocapture method to determine cellular sources of replicating populations of HIV-1 in vivo by Gartner, K, Frater, J, Phillips, R, Klenerman, P, Simmonds, P

Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level by Neumann-Haefelin, C, Frick, D, Wang, J, Pybus, O, Salloum, S, Narula, G, Eckart, A, Biezynski, A, Eiermann, T, Klenerman, P, Viazov, S, Roggendorf, M, Thimme, R, Reiser, M, Timm, J

Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. by Chuang, W, Sarkodie, F, Brown, C, Owusu-Ofori, S, Brown, J, Li, C, Navarrete, C, Klenerman, P, Allain, J

“…Recovery from Hepatitis C virus (HCV) infection is considered infrequent (<20%) in western populations but reaches 50% in West Africa where genotype 2 infection is predominant. …”

Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level. by Neumann-Haefelin, C, Frick, D, Wang, J, Pybus, O, Salloum, S, Narula, G, Eckart, A, Biezynski, A, Eiermann, T, Klenerman, P, Viazov, S, Roggendorf, M, Thimme, R, Reiser, M, Timm, J

“…Comparison of HCV sequences from Asia and Europe suggests that the frequency of the HLA-A*01 allele in a population may influence the frequency of the escape variant in circulating strains. …”

Predicting the dynamics of antiviral cytotoxic T-cell memory in response to different stimuli: cell population structure and protective function. by Bocharov, G, Klenerman, P, Ehl, S

“…The model is based upon biological evidence from the murine model of infection with lymphocytic choriomeningitis virus (LCMV) that the phenotype of immunological memory represents low-level responses driven by various stimuli, and the memory CTL population is partitioned between resting, cycling and effector cells. …”

Fine needle aspiration of human lymph nodes reveals cell populations and soluble interactors pivotal to immunological priming by Provine, NM, Al-Diwani, A, Agarwal, D, Dooley, K, Heslington, A, Murchison, AG, Garner, LC, Sheerin, F, Klenerman, P, Irani, SR

“…Examination of these populations reveals unique biology not predictable from equivalent blood-derived populations. …”

A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice by Hackstein, C-P, Costigan, D, Drexhage, L, Pearson, C, Bullers, S, Ilott, N, Akther, HD, Gu, Y, FitzPatrick, MEB, Harrison, OJ, Garner, LC, Mann, EH, Pandey, S, Friedrich, M, Provine, NM, Uhlig, HH, Marchi, E, Powrie, F, Klenerman, P, Thornton, EE

“…Here we show that MHC-II restricted, commensal-reactive T cells in the colon of both humans and mice acquire transcriptional and functional characteristics associated with innate-like T cells. This cell population is abundant and conserved in the human and murine colon and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis. …”

Large scale analysis of pediatric antiviral CD8+ T cell populations reveals sustained, functional and mature responses. by Komatsu, H, Inui, A, Sogo, T, Fujisawa, T, Nagasaka, H, Nonoyama, S, Sierro, S, Northfield, J, Lucas, M, Vargas, A, Klenerman, P

“… BACKGROUND: Cellular immunity plays a crucial role in cytomegalovirus (CMV) infection and substantial populations of CMV-specific T cells accumulate throughout life. …”

Inflation vs exhaustion of antiviral CD8+ t-cell populations in persistent infections: two sides of the same coin? by Marchi, E, Lee, L, Klenerman, P

“…On the other, low-level persistence of viruses such as Cytomegalovirus and Adenoviral vaccines can drive memory "inflation," associated with sustained populations of CD8+ T-cells over time, with maintained effector functions and a distinct phenotype. …”

Ultra-sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8+ T cells. by Barnes, E, Ward, S, Kasprowicz, V, Dusheiko, G, Klenerman, P, Lucas, M

“…Therefore, we assessed the use of anti-PE-labeled magnetic beads to enrich tetramer-positive HCV-specific T cells and identify previously undetectable populations. Using the enrichment technique, HCV-specific T cells could be detected in the majority of infected individuals, whereas these responses were not detected using conventional tetramer staining (8/15 vs. 1/15; p=0.01). …”