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Molecular simulations of hydrophobic gating of pentameric ligand gated ion channels: Insights into water and ions
Published 2021“…Ion channels are proteins which form gated nanopores in biological membranes. Many channels exhibit hydrophobic gating, whereby functional closure of a pore occurs by local dewetting. …”
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A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates
Published 2019“…Ion channel proteins control ionic flux across biological membranes through conformational changes in their transmembrane pores. …”
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3
Water and hydrophobic gates in ion channels and nanopores
Published 2018“…Ion channel proteins form nanopores in biological membranes which allow the passage of ions and water molecules. …”
Journal article