Cardiovascular event rates in the MOSAIC trial: 2-year follow-up data. by Turnbull, C, Craig, S, Kohler, M, Nicoll, D, Stradling, J

“…The Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial investigated the effect of continuous positive airway pressure (CPAP) on both sleepiness and predicted cardiovascular risk over 6 months in minimally symptomatic patients with obstructive sleep apnoea. …”

Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA by Craig, S, Kohler, M, Ayers, L, Nunn, A, Bratton, D

“…The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). …”

CPAP IMPROVES ENDOTHELIAL FUNCTION IN MINIMALLY SYMPTOMATIC OSA PATIENTS: RESULTS FROM THE MOSAIC TRIAL by Kohler, M, Craig, SE, Pepperell, J, Nicoll, D, Bratton, D, Nunn, A, Davies, R, Stradling, JR

Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial by Tang, I, Turnbull, CD, Sen, D, Craig, S, Kohler, M, Stradling, JR

“…Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. …”

THE PRIMARY RESULTS OF THE MOSAIC TRIAL: DOES CPAP FOR MINIMALLY SYMPTOMATIC OSA REDUCE DAYTIME SLEEPINESS OR CALCULATED VASCULAR RISK? by Craig, SE, Kohler, M, Nicoll, D, Bretton, D, Nunn, A, Davies, R, Stradling, JR

CPAP improves endothelial function in patients with minimally symptomatic OSA: results from a subset study of the MOSAIC trial. by Kohler, M, Craig, S, Pepperell, J, Nicoll, D, Bratton, D, Nunn, A, Leeson, P, Stradling, JR

“…METHODS: In two centers taking part in the MOSAIC (Multicentre Obstructive Sleep Apnoea Interventional Cardiovascular) trial, 253 patients with minimally symptomatic OSA were randomized to 6 months of CPAP or standard care. …”

TWO YEAR VASCULAR EVENT, HOSPITAL ADMISSIONS, AND ACCIDENT INCIDENCE: FURTHER DATA FROM THE MOSAIC SLEEP APNOEA TRIAL by Turnbull, C, Craig, S, Kohler, M, Nicoll, D, Stradling, J

Effect of CPAP on cardiac function in minimally symptomatic patients with OSA: results from a subset of the MOSAIC randomized trial by Craig, S, Kylintireas, I, Kohler, M, Nicoll, D, Bratton, D, Nunn, A, Leeson, P, Neubauer, S, Stradling, J

“…METHODS: Two centers taking part in the MOSAIC trial randomized 238 patients in parallel to 6 months of CPAP (120) or standard care (118). …”

Predictors Of continuous positive airways pressure usage at six months in minimally symptomatic patients: further data from the MOSAIC trial by Turnbull, C, Craig, S, Kohler, M, Stradling, J

ECG risk markers for atrial fibrillation and sudden cardiac death in minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised trial. by Schlatzer, C, Bratton, D, Craig, S, Kohler, M, Stradling, J

“…Whether or not CPAP therapy improves ECG risk markers of AF and SCD in patients with minimally symptomatic OSA as well, is unknown.3 centres taking part in the MOSAIC (Multicentre Obstructive Sleep Apnoea Interventional Cardiovascular) trial randomisd 303 patients with minimally symptomatic OSA to receive either CPAP or standard care for 6 months. …”

Predictors of continuous positive airways pressure usage at six months in minimally symptomatic patients: further data from the MOSAIC trial. by Turnbull, C, Bratton, D, Craig, S, Kohler, M, Stradling, J

Continuous positive airway pressure improves sleepiness but not calculated vascular risk in patients with minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised controlled trial. by Craig, SE, Kohler, M, Nicoll, D, Bratton, D, Nunn, A, Davies, R, Stradling, J

Continuous positive airway pressure improves sleepiness but not calculated vascular risk in patients with minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised controlled trial. by Craig, SE, Kohler, M, Nicoll, D, Bratton, D, Nunn, A, Davies, R, Stradling, J

Leukoaraiosis on MRI in patients with minimally symptomatic obstructive sleep apnoea. by Schulz, U, Mason, R, Craig, SE, Howard, S, Nicoll, D, Kohler, M, Rothwell, P, Stradling, J

“…METHODS: We studied patients who were part of a clinical trial (MOSAIC) in minimally symptomatic OSA. All patients had brain MRI (T2, FLAIR) at baseline. …”

In patients with minimally symptomatic OSA can baseline characteristics and early patterns of CPAP usage predict those who are likely to be longer-term users of CPAP by Turnbull, CD, Bratton, DJ, Craig, SE, Kohler, M, Stradling, JR

“…</p> <p><strong>Methods:</strong> The MOSAIC trial was a multi-centre randomised controlled trial where minimally symptomatic OSA patients were randomised to CPAP, or standard care, for 6 months. …”