Cardiac effects of antimalarial treatment with halofantrine. by Nosten, F, ter Kuile, F, Luxemburger, C, Woodrow, C, Kyle, D, Chongsuphajaisiddhi, T, White, N

“…More than 60% of the effect occurred with three doses of halofantrine (24 mg/kg). The arrhythmogenic potential of halofantrine should now be investigated.…”

Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. by Krishna, S, ter Kuile, F, Supanaranond, W, Pukrittayakamee, S, Teja-Isavadharm, P, Kyle, D, White, N

“…1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12 adults with acute uncomplicated falciparum malaria and nine adults who attended in convalescence. 2 Intravenous halofantrine (1 mg kg(-1) infused in 1 h) was given every 8 h for a total of three doses in the acute study. …”