Analgesic treatment, by using a systemic algorithm by A. E. Karateev, L. I. Alekseeva

“…This necessitates a comprehensive approach during analgesic therapy, with combined use of drugs having a different mechanism of analgesic action. …”
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Toll-like receptors as a part of osteoarthritis pathophysiology: anti-inflammatory, analgesic and neuroprotective effects by I. Yu. Torshin, O. A. Gromova, A. M. Lila, L. I. Alekseeva, E. A. Taskina

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GENERAL PRINCIPLES OF TREATMENT FOR MUSCULOSKELETAL PAIN: INTERDISCIPLINARY CONSENSUS by E. L. Nasonov, N. N. Yakhno, A. E. Karateev, L. I. Alekseeva, A. N. Barinov, A. E. Barulin, O. S. Davydov, A. B. Danilov, M. V. Zhuravleva, B. V. Zavodovsky, S. S. Kopenkin, M. L. Kukishkin, V. A. Parfenov, M. A. Strakhov, V. P. Tyurin, N. V. Chichasova, S. A. Chorbinskaya

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Use of tanezumab for chronic pain treatment by A. E. Karateev, A. M. Lila, L. I. Alekseeva

“…This leads to the search for new approaches for analgesic therapy. Tanezumab is a monoclonal antibody that specifically blocks nerve growth factor, which plays a key role in the development of chronic pain. …”
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Osteoarthritis as an interdisciplinary problem: treatment algorithm for physicians and general practitioners by A. M. Lila, L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova

“…It has been demonstrated that the early use of the well-proven SYSADOA in any localization of OA, in particular the combined drugs of chondroitin sulfate and glucosamine, can increase the effectiveness of treatment, reduce possible functional disorders, and minimize the adverse effects of analgesic therapy.…”
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Meloxicam in rheumatology practice: The history of its use in the therapy of pain by L. I. Alekseeva, P. S. Kovalenko

“…The results of numerous investigations show that meloxicam has a good efficacy/safety ratio and noticeable analgesic and anti-inflammatory effects, which makes it the drug of choice for the treatment of a wide range of rheumatic diseases and acute and chronic diseases of the joint and spinal column. …”
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The efficacy and safety of glycosaminoglycan-peptide complex in patients with knee osteoarthritis and comorbidity: a multicenter prospective study by L. I. Alekseeva, E. A. Taskina, N. G. Kashevarova, E. P. Sharapova, E. A. Strebkova, S. G. Anikin, N. V. Chichasova, T. A. Raskina, E. V. Zonova, E. N. Otteva, E. I. Shmidt, S. P. Yakupova, I. B. Vinogradova, O. N. Ivanova, V. A. Lila, B. V. Zavadovsky, P. A. Shesternya, A. M. Lila

“…The drug is shown to have a rapid analgesic and anti-inflammatory effect, as well as a positive influence on all clinical manifestations of OA.…”
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EFFICIENCY OF DYNAMIC ELECTRONEUROSTIMULATION IN KNEE OSTEOARTHRITIS: RESULTS OF A MULTICENTER RANDOMIZED STUDY by O. M. Lesnyak, E. Yu. Kadochnikova, L. I. Alekseeva, I. G. Dydykina, O. B. Ershova, E. M. Zaitseva, T. A. Korotkova, T. A. Popova, M. L. Sukhareva, E. A. Taskina, V. N. Khodyrev, E. P. Sharapova, A. G. Solodovnikov, A. A. Vlasov

“…Therewas a statistically significant difference in pain in the compared groups after a treatment session during the first (p = 0.037) and second (p = 0.010) visits. The analgesic effect of therapy was observed to persist in the DENS group 2 weeks (p = 0.006) and 1 month (p = 0.070) after treatment termination. …”
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Clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice» by A. E. Karateev, E. L. Nasonov, N. N. Yakhno, V. T. Ivashkin, N. V. Chichasova, L. I. Alekseeva, Yu. A. Karpov, M. A. Evseev, M. L. Kukushkin, A. B. Danilov, O. V. Vorobyeva, A. V. Amelin, D. S. Novikova, O. M. Drapkina, S. S. Kopenkin, G. R. Abuzarova

“…The paper presents the new version of the clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice » prepared by the Association of Rheumatologists of Russia, the Russian Pain Society, the Russian Gastroenterological Association, the Russian Society of Cardiology, the Association of Traumatologists and Orthopedists of Russia, the Association of Interdisciplinary Medicine, and the Russian Association of Palliative Medicine.In our country, NSAIDs are the most important and most popular class of analgesics. Unlike global practice, Russian physicians rather rarely recommend paracetamol as a first-line drug to relieve moderate or severe pain, by giving preference to NSAIDs; the use of opioid analgesics for noncancers is minimized because of tight legal restrictions.NSAIDs are effective and easy-to-use; however, they are far from safe; the administration of these medications may lead to serious gastrointestinal, cardiovascular, renal, and other complications in a number of cases. …”
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Use of Artra and Artra MSM Forte in osteoarthritis of the large joints and lowback pain by E. P. Sharapova, L. I. Alekseeva

“…These drugs are currently recommended to prescribe as the first-line drugs to treat OA. Analgesics and NSAIDs that rarely cause adverse effects, especially in older people and in patients with co-morbidities, who receive concomitant medications, are the most commonly prescribed medications for pain relief. …”
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