Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study by Fedirko, V, Tran, H, Gewirtz, A, Stepien, M, Trichopoulou, A, Aleksandrova, K, Olsen, A, Tjønneland, A, Overvad, K, Carbonnel, F, Boutron-Ruault, M, Severi, G, Kühn, T, Kaaks, R, Boeing, H, Bamia, C, Lagiou, P, Grioni, S, Panico, S, Palli, D, Tumino, R, Naccarati, A, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Castaño, J, Barricarte, A, Sánchez, M, Dorronsoro, M, Quirós, J, Agudo, A, Sjöberg, K, Ohlsson, B, Hemmingsson, O, Werner, M, Bradbury, K, Khaw, K, Wareham, N, Tsilidis, K, Aune, D, Scalbert, A, Romieu, I, Riboli, E, Jenab, M

“…</p><p>METHODS: We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. …”

Postmenopausal serum sex steroids and risk of hormone receptor-positive and -negative breast cancer: a nested case-control study. by James, R, Lukanova, A, Dossus, L, Becker, S, Rinaldi, S, Tjønneland, A, Olsen, A, Overvad, K, Mesrine, S, Engel, P, Clavel-Chapelon, F, Chang-Claude, J, Vrieling, A, Boeing, H, Schütze, M, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Krogh, V, Panico, S, Tumino, R, Sacerdote, C, Rodríguez, L, Buckland, G

“…In a case-control study nested within the EPIC cohort (European Prospective Investigation into Cancer and Nutrition), estradiol, testosterone, and sex hormone-binding globulin levels were measured in prediagnostic serum samples from postmenopausal women not using hormone replacement therapy at blood donation. …”

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort. by Hosnijeh, F, Lan, Q, Rothman, N, San Liu, C, Cheng, W, Nieters, A, Guldberg, P, Tjønneland, A, Campa, D, Martino, A, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Krogh, V, Tumino, R, Panico, S, Masala, G, Weiderpass, E, Huerta Castaño, J, Ardanaz, E, Sala, N, Dorronsoro, M, Quirós, JR, Sánchez, M

“…However, current evidence is limited and based on a relatively small number of cases. Using a nested case-control study, we extended these findings with a focus on subtype-specific analyses. …”

Primary brain tumours and specific serum immunoglobulin E: A case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort by Schlehofer, B, Siegmund, B, Linseisen, J, Schüz, J, Rohrmann, S, Becker, S, Michaud, D, Melin, B, Bas Bueno-De-Mesquita, H, Peeters, P, Vineis, P, Tjonneland, A, Olsen, A, Overvad, K, Romieu, I, Boeing, H, Aleksandrova, K, Trichopoulou, A, Bamia, C, Lagiou, P, Sacerdote, C, Palli, D, Panico, S, Sieri, S, Tumino, R

“…Methods: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. …”

Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort. by Schlehofer, B, Siegmund, B, Linseisen, J, Schüz, J, Rohrmann, S, Becker, S, Michaud, D, Melin, B, Bas Bueno-de-Mesquita, H, Peeters, P, Vineis, P, Tjonneland, A, Olsen, A, Overvad, K, Romieu, I, Boeing, H, Aleksandrova, K, Trichopoulou, A, Bamia, C, Lagiou, P, Sacerdote, C, Palli, D, Panico, S, Sieri, S, Tumino, R

“…METHODS: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Circulating C-reactive protein concentrations and risks of colon and rectal cancer: a nested case-control study within the European Prospective Investigation into Cancer and Nutrition. by Aleksandrova, K, Jenab, M, Boeing, H, Jansen, E, Bueno-de-Mesquita, H, Rinaldi, S, Riboli, E, Overvad, K, Dahm, C, Olsen, A, Tjønneland, A, Boutron-Ruault, M, Clavel-Chapelon, F, Morois, S, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Kaaks, R, Rohrmann, S, Trichopoulou, A, Lagiou, P, Trichopoulos, D, van Duijnhoven, F

“…The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. …”

Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case-control study by Huang, J, Zagai, U, Hallmans, G, Nyrén, O, Engstrand, L, Stolzenberg-Solomon, R, Duell, E, Overvad, K, Katzke, V, Kaaks, R, Jenab, M, Park, J, Murillo, R, Trichopoulou, A, Lagiou, P, Bamia, C, Bradbury, K, Riboli, E, Aune, D, Tsilidis, K, Capellá, G, Agudo, A, Krogh, V, Palli, D, Panico, S, Weiderpass, E, Tjønneland, A, Olsen, A, Martínez, B, Redondo-Sanchez, D, Chirlaque, M, Hm Peeters, P, Regnér, S, Lindkvist, B, Naccarati, A, Ardanaz, E, Larrañaga, N, Boutron-Ruault, M, Rebours, V, Barré, A, Bueno-de-Mesquita, H, Ye, W

“…The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. …”

Dairy products and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition. by Duarte-Salles, T, Fedirko, V, Stepien, M, Trichopoulou, A, Bamia, C, Lagiou, P, Lukanova, A, Trepo, E, Overvad, K, Tjønneland, A, Halkjaer, J, Boutron-Ruault, M, Racine, A, Cadeau, C, Kühn, T, Aleksandrova, K, Trichopoulos, D, Tsiotas, K, Boffetta, P, Palli, D, Pala, V, Tumino, R, Sacerdote, C, Panico, S, Bueno-de-Mesquita, H

“…For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. …”

Dairy products and risk of hepatocellular carcinoma: The European Prospective Investigation into Cancer and Nutrition by Duarte-Salles, T, Fedirko, V, Stepien, M, Trichopoulou, A, Bamia, C, Lagiou, P, Lukanova, A, Trepo, E, Overvad, K, Tjønneland, A, Halkjær, J, Boutron-Ruault, M, Racine, A, Cadeau, C, Kühn, T, Aleksandrova, K, Trichopoulos, D, Tsiotas, K, Boffetta, P, Palli, D, Pala, V, Tumino, R, Sacerdote, C, Panico, S, Bueno-De-Mesquita, H

“…For cohort analyses, multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). For nested case-control analyses, conditional logistic regression was used to calculate odds ratios and 95% CI. …”

Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). by Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, V, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, H, Peeters, P

“…Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured. …”

Metabolic Mediators of the association between adult weight gain and Colorectal cancer: Data from European prospective investigation into Cancer and nutrition (EPIC) Cohort by Bradbury, K, Aleksandrova, K, Schlesinger, S, Fedirko, V, Jenab, M, Bueno-de-Mesquita, B, Freisling, H, Romieu, I, Pischon, T, Kaaks, R, Gunter, M, Dahm, C, Overvad, K, Rostgaard-Hansen, A, Tjønneland, A, Bamia, C, Lagiou, P, Agnoli, C, Mattielo, A, Khaw, K, Riboli, E, Boeing, H

“…We evaluated the mediation effect of 20 different biomarkers on the relation between adult weight gain and colorectal cancer using data from a prospective nested case-control study among 452 incident cases diagnosed between 1992 and 2003, and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition Cohort. …”

Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study. by Hosnijeh, F, Matullo, G, Russo, A, Guarrera, S, Modica, F, Nieters, A, Overvad, K, Guldberg, P, Tjønneland, A, Canzian, F, Boeing, H, Aleksandrova, K, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Tagliabue, G, Tumino, R, Panico, S, Palli, D, Olsen, K, Weiderpass, E, Dorronsoro, M, Ardanaz, E, Chirlaque, MD, Sánchez, M

“…The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. …”

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study by Michaud, D, Izard, J, Wilhelm-Benartzi, C, You, D, Grote, V, Tjønneland, A, Dahm, C, Overvad, K, Jenab, M, Fedirko, V, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Kaaks, R, Boeing, H, Foerster, J, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Sieri, S, Palli, D, Tumino, R, Panico, S, Siersema, P

“…Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. …”

Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition. by Schmidt, J, Allen, N, Almquist, M, Franceschi, S, Rinaldi, S, Tipper, S, Tsilidis, K, Weiderpass, E, Overvad, K, Tjønneland, A, Boutron-Ruault, M, Dossus, L, Mesrine, S, Kaaks, R, Lukanova, A, Boeing, H, Lagiou, P, Trichopoulos, D, Trichopoulou, A, Palli, D, Krogh, V, Panico, S, Tumino, R, Zanetti, R, Bueno-de-Mesquita, H

“…METHODS: This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. …”

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. by Michaud, D, Izard, J, Wilhelm-Benartzi, C, You, D, Grote, V, Tjønneland, A, Dahm, C, Overvad, K, Jenab, M, Fedirko, V, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Kaaks, R, Boeing, H, Foerster, J, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Sieri, S, Palli, D, Tumino, R, Panico, S, Siersema, P

“…DESIGN: We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. …”

Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. by Rohrmann, S, Grote, V, Becker, S, Rinaldi, S, Tjønneland, A, Roswall, N, Grønbæk, H, Overvad, K, Boutron-Ruault, M, Clavel-Chapelon, F, Racine, A, Teucher, B, Boeing, H, Drogan, D, Dilis, V, Lagiou, P, Trichopoulou, A, Palli, D, Tagliabue, G, Tumino, R, Vineis, P, Mattiello, A, Rodríguez, L, Duell, E, Molina-Montes, E

“…Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. …”

Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition. by Rohrmann, S, Linseisen, J, Becker, S, Allen, N, Schlehofer, B, Overvad, K, Olsen, A, Tjønneland, A, Melin, B, Lund, E, Vineis, P, Grioni, S, Tumino, R, Palli, D, Mattiello, A, Bonet, C, Chirlaque, MD, Sánchez, M, Rodríguez, L, Dorronsoro, M, Ardanaz, E, Lagiou, P, Trichopoulou, A, Trichopoulos, D, Dossus, L

“…METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. …”