Metabolic energy sensors as targets for designing host-directed therapies for tuberculosis by Cheng, Catherine Y., Böhme, Julia, Singhal, Amit

“…Studies have indicated that inflammatory responses are intrinsically linked to cellular metabolism and together drive the fate of many host responses, coupling host survival with the capacity to respond to infectious insult. …”
Get full text
Get full text

Macrophage–Bacteria Interactions—A Lipid-Centric Relationship by Teng, Ooiean, Ang, Candice Ke En, Guan, Xue Li

“…Tight regulation of cellular metabolism is critical in shaping the macrophage polarization states and immune functions. …”
Get full text
Get full text

Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer by Di Sante, Gabriele, Di Rocco, Agnese, Pupo, Claudia, Casimiro, Mathew C., Pestell, Richard G.

“…Genomic DNA is assaulted by damaging ionizing radiation, chemical carcinogens, and reactive oxygen species (ROS) which are generated by cellular metabolism. Furthermore, specific hormones including estrogens [3, 4] and androgens [5] govern pathways that damage DNA. …”
Get full text
Get full text

Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression by Teo, Ziqiang, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Lim, Maegan Miang Kee, Li, Yinliang, Li, Luchun, Phua, Terri, Lee, J. Y. H., Tan, Zhen Wei, Zhu, Pengcheng, Tan, Nguan Soon

“…This augmented cellular metabolic activity enhanced metastasis. ANGPTL4 knockdown suppresses an adenylate energy charge elevation, delaying EMT. …”
Get full text
Get full text

Functional regulation of ppars through post-translational modifications by Brunmeir, Reinhard, Xu, Feng

“…Given their central roles in sensing the cellular metabolic state and controlling metabolic homeostasis, PPARs became important targets of drug development for the management of metabolic disorders. …”
Get full text
Get full text