Dissolving triamcinolone-embedded microneedles for the treatment of keloids : a single-blinded intra-individual controlled clinical trial by Tan, Colin W. X., Tan, Wei Ding, Srivastava, Ruchir, Yow, Ai Ping, Wong, Damon Wing Kee, Tey, Hong Liang

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A phase 4 multicentre, 2×2 factorial randomised, double-blind, placebo-controlled trial to investigate the efficacy and safety of tobramycin inhalation solution for Pseudomonas aeruginosa eradication in bronchiectasis: ERASE by Gao, Yong-Hua, Lu, Hai-Wen, Zheng, Hui-Zhen, Cao, Chao, Chu, De-Jie, Fan, Hong, Fan, Xiao-Yun, Gu, Hong-Yan, Guan, Wei-Jie, Jie, Zhi-Jun, Jin, Yang, Li, Wen, Li, Yu-Ping, Li, Yuan-Yuan, Liu, Lin, Liu, Xue-Dong, Luo, Hong, Lv, Xiao-Dong, Mo, Wei-Qiang, Song, Yuan-Lin, Wang, Dao-Xin, Wang, Ling-Wei, Wang, Chang-Zheng, Xie, Min, Zhang, Min, Zheng, Cui-Xia, Mao, Bei, Chotirmall, Sanjay Haresh, Chalmers, James D., Qu, Jie-Ming, Xu, Jin-Fu

“…This multicentre, 2×2 factorial randomised, double-blind, placebo-controlled, parallel-group trial includes a 2-week screening period, a 12-week treatment phase (with a combination of ciprofloxacin or a placebo at initial 2 weeks) and a 24-week follow-up. 364 adults with bronchiectasis and a new PA isolation will be randomly assigned to one of four groups: placebo (inhaled saline and ciprofloxacin placebo twice daily), ciprofloxacin alone (750 mg ciprofloxacin and inhaled saline twice daily), inhaled tobramycin alone (inhaled 300 mg tobramycin and ciprofloxacin placebo twice daily) or a combination of both drugs (inhaled 300 mg tobramycin and 750 mg ciprofloxacin twice daily). …”
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Computer-aided diagnosis of glaucoma using fundus images : a review by Hagiwara, Yuki, Koh, Joel En Wei, Tan, Jen Hong, Bhandary, Sulatha V., Laude, Augustinus, Ciaccio, Edward J., Tong, Louis, Acharya, U. Rajendra

“…Background and objectives: Glaucoma is an eye condition which leads to permanent blindness when the disease progresses to an advanced stage. …”
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Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells by Almaça, Joana, Molina, Judith, Menegaz, Danusa, Pronin, Alexey N., Tamayo, Alejandro, Slepak, Vladlen, Berggren, Per-Olof, Caicedo, Alejandro

“…Without serotonergic input, alpha cells lose their ability to regulate glucagon secretion in response to changes in glucose concentration, suggesting that diminished serotonergic control of alpha cells can cause glucose blindness and the uncontrolled glucagon secretion associated with diabetes. …”
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Largazole inhibits ocular angiogenesis by modulating the expression of VEGFR2 and p21 by Qiu, Beiying, Tan, Alison, Tan, Yu Zhi, Chen, Qi-Yin, Luesch, Hendrik, Wang, Xiaomeng

“…Ocular angiogenic diseases, characterized by abnormal blood vessel formation in the eye, are the leading cause of blindness. Although Anti-VEGF therapy is the first-line treatment in the market, a substantial number of patients are refractory to it or may develop resistance over time. …”
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Functional evaluation of two corneal endothelial cell-based therapies : tissue-engineered construct and cell injection by Peh, Gary S. L., Ong, Hon Shing, Adnan, Khadijah, Ang, Heng-Pei, Lwin, Chan N., Seah, Xin-Yi, Lin, Shu-Jun, Mehta, Jodhbir Singh

“…Restoration of vision due to corneal blindness from corneal endothelial dysfunction can be achieved via a corneal transplantation. …”
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Longitudinal analysis of retinal microvascular and choroidal imaging parameters in Parkinson's disease compared with controls by Kundu, Anita, Ma, Justin P., Robbins, Cason B., Pant, Praruj, Gunasan, Vithiya, Agrawal, Rupesh, Stinnett, Sandra, Scott, Burton L., Moore, Kathryn P. L., Fekrat, Sharon, Grewal, Dilraj S.

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Clinical features and predictors of treatment outcome in patients with ocular tuberculosis from the Netherlands and Indonesia: the OculaR TB in low versus high endemic countries (O... by Putera, Ikhwanuliman, ten Berge, Josianne C. E. M., Thiadens, Alberta A. H. J., Dik, Willem A., Agrawal, Rupesh, van Hagen, P Martin, La Distia Nora, Rina, Rombach, Saskia M.

“…Indonesian cohort exhibited a more acute and severe disease profile, including uveitis duration ≤ 3 months (p < 0.001), blindness (p < 0.001), anterior chamber (AC) cells ≥ 2+ (p < 0.001), and posterior synechiae (p < 0.001). …”
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Evaluation of a digital Amsler grid (PocDoc) for macular disease screening: a comparative analysis with the conventional method by Boon, Joewee, Rojas-Carabali, William, Asad, Yusra, Lim, Jonathan Tzien Yih, Rajagopalan, Rajesh, Agrawal, Rupesh

“…Introduction: Macular diseases are major contributors to visual impairment and blindness worldwide. This study introduces PocDoc, a digital version of the conventional Amsler grid, aimed at enhancing the screening and monitoring of macular diseases. …”
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Artificial intelligence and deep learning in ophthalmology by Ting, Daniel Shu Wei, Pasquale, Louis R., Peng, Lily, Campbell, John Peter, Lee, Aaron Y., Raman, Rajiv, Tan, Gavin Siew Wei, Schmetterer, Leopold, Keane, Pearse A., Wong, Tien Yin

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Ocular microvascular complications in diabetic retinopathy: insights from machine learning by Ahmed, Thiara S., Shah, Janika, Zhen, Yvonne N. B., Chua, Jacqueline, Wong, Damon W. K., Nusinovici, Simon, Tan, Rose, Tan, Gavin, Schmetterer, Leopold, Tan, Bingyao

“…Introduction: Diabetic retinopathy (DR) is a leading cause of preventable blindness among working-age adults, primarily driven by ocular microvascular complications from chronic hyperglycemia. …”
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Update to: Assessing the efficacy of male Wolbachia-infected mosquito deployments to reduce dengue incidence in Singapore by Lim, Jue Tao, Mailepessov, Diyar, Chong, Chee-Seng, Chang, Chia-Chen, Dickens, Borame, Lai, Yee Ling, Deng, Lu, Lee, Caleb, Tan, Li Yun, Chain, Grace, Ho, Soon Hoe, Muhammad Faizal Zulkifli, Liew, Jonathan, Vasquez, Kathryn, Lee, Vernon, Wong, Judith Chui Ching, Sim, Shuzhen, Tan, Cheong Huat, Ng, Lee Ching

“…Background: This trial is a parallel, two-arm, non-blinded cluster randomised controlled trial that is under way in Singapore, with the aim of measuring the efficacy of male Wolbachia-infected Aedes aegypti deployments in reducing dengue incidence in an endemic setting with all four dengue serotypes in circulation. …”
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Differential effects of monounsaturated and polyunsaturated fats on satiety and gut hormone responses in healthy subjects by Sun, Lijuan, Goh, Hui Jen, Govindharajulu, Priya, Leow, Melvin Khee-Shing, Henry, Christiani Jeyakumar

“…A randomized, controlled, single-blinded crossover study was conducted in 13 healthy Chinese men. …”
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Complement factor B mediates ocular angiogenesis through regulating the VEGF signaling pathway by Murray, Hannah, Qiu, Beiying, Ho, Sze Yuan, Wang, Xiaomeng

“…In addition to its role in activating the AP, CFB has been implicated in pathological ocular neovascularization, a common feature of several blinding eye diseases, however, with somewhat conflicting results. …”
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Can a brief online interdisciplinary program enhance the understanding of musculoskeletal pain amongst primary care staff? A prospective study by Ng, Khim Siong, Goh, Bandy Qiuling, Tang, Woh Peng, Lee, Angela Wing Yan, Lee, Samantha, Koh, Kim Hwee, Shah, Mitesh

“…Methods: We piloted a multicenter single-blind prospective study on sixty-four staff from the pharmacy department in eight public primary care clinics. …”
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The immune response to 6-monthly versus annual standard dose inactivated trivalent influenza vaccination in older people: study protocol for a randomised clinical trial by Young, Barnaby, Sadarangani, Sapna, Yew, Haur Sen, Yung, Chee Fu, Leo, Yee Sin, Chen, Mark I-Cheng, Wilder-Smith, Annelies

“…Methods/design: This is a single-centre, randomised, observer-blind, active-comparator controlled, parallel-group, phase IV trial in 200 adults aged 65 years or older. …”
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The effect of vitamin D supplementation in pregnant women with overweight and obesity: a randomised controlled trial by Ku, Chee Wai, Lee, Angeline Jia Wen, Oh, Benjarat, Lim, Celeste Hong Fei, Chang, Ting Yu, Yap, Fabian, Chan, Jerry Kok Yen, Loy, See Ling

“…This was a two-arm, parallel, non-blinded randomised controlled trial involving 274 pregnant women recruited from KK Women's and Children's Hospital, with a body mass index of ≥25 kg/m2 within 16 weeks gestation. …”
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A phase 2 randomised study to establish efficacy, safety and dosing of a novel oral cathepsin C inhibitor, BI 1291583, in adults with bronchiectasis: Airleaf by Chalmers, James D., Gupta, Abhya, Chotirmall, Sanjay Haresh, Armstrong, April, Eickholz, Peter, Hasegawa, Naoki, McShane, Pamela J., O'Donnell, Anne E., Shteinberg, Michal, Watz, Henrik, Eleftheraki, Anastasia, Diefenbach, Claudia, Sauter, Wiebke

“…This multinational, randomised, double-blind, placebo-controlled, parallel-group, dose-finding study has a screening period of at least 6 weeks, a treatment period of 24-48 weeks and a follow-up period of 4 weeks. ∼240 adults with bronchiectasis of multiple aetiologies will be randomised to placebo once daily, or BI 1291583 1 mg once daily, 2.5 mg once daily or 5 mg once daily in a 2:1:1:2 ratio, stratified by Pseudomonas aeruginosa infection and maintenance use of macrolides. …”
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Gamified M-health attention bias modification intervention for individuals with opioid use disorder : protocol for a pilot randomised study by Zhang, Melvyn, Heng, Sandor, Amron, Syidda B., Mahreen, Zaakira, Song, Guo, Fung, Daniel Shuen Sheng, Smith, Helen

“…Methods and Analysis: A non-blinded pilot randomized trial will be conducted. …”
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Developing item banks to measure three important domains of health-related quality of life (HRQOL) in Singapore by Uy, Elenore Judy B., Xiao, Lynn Yun Shan, Xin, Xiaohui, Yeo, Joanna Peck Tiang, Pua, Yong Hao, Lee, Geok Ling, Kwan, Yu Heng, Teo, Edmund Pek Siang, Vaingankar, Janhavi Ajit, Subramaniam, Mythily, Chan, Mei Fen, Kumar, Nisha, Ang, Alcey Li Chang, Bautista, Dianne Carrol, Cheung, Yin Bun, Thumboo, Julian

“…Items from these three sources were “binned” and “winnowed” by two independent reviewers, blinded to the source of the items, who harmonized their selections to generate a list of candidate items (each item representing a subdomain). …”
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