Dengue uveitis - a major review by Xie, Amy Cen, Ng, Aaron Wei Wen, Rojas-Carabali, William, Cifuentes-González, Carlos, de-la-Torre, Alejandra, Mahendradas, Padmamalini, Agrawal, Rupesh

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Structure of the competence pilus major pilin ComGC in Streptococcus pneumoniae by Muschiol, Sandra, Erlendsson, Simon, Aschtgen, Marie-Stephanie, Oliveira, Vitor, Schmieder, Peter, De Lichtenberg, Casper, Teilum, Kaare, Boesen, Thomas, Akbey, Umit, Henriques-Normark, Birgitta

“…These “competence pili” are composed of the major pilin protein ComGC and exclusively assembled during bacterial competence, but their biogenesis remains unclear. …”
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Rickettsioses as major etiologies of unrecognized acute febrile illness, Sabah, East Malaysia by Grigg, Matthew J., William, Timothy, Clemens, Emily G., Patel, Kaajal, Chandna, Arjun, Wilkes, Christopher S., Barber, Bridget E., Anstey, Nicholas M., Dumler, J. Stephen, Yeo, Tsin Wen, Reller, Megan E.

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Mechanistic insights into the activities of major families of enzymes in bacterial peptidoglycan assembly and breakdown by Kwan, Jeric Mun Chung, Qiao, Yuan

“…In this review, we discuss recent findings on the biochemical activities of major peptidoglycan enzymes, including peptidoglycan glycosyltransferases (PGT) and transpeptidases (TPs) in the final stage of peptidoglycan assembly, as well as peptidoglycan glycosidases, lytic transglycosylase (LTs), amidases, endopeptidases (EPs) and carboxypeptidases (CPs) in peptidoglycan turnover and metabolism. …”
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Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes by Gurung, Resham L., Liu, Sylvia, Liu, Jian-Jun, Yiamunaa, M., Zheng, Huili, Chan, Clara, Ang, Keven, Subramaniam, Tavintharan, Sum, Chee Fang, Lim, Su Chi

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Subjective quality of life among patients with schizophrenia spectrum disorder and patients with major depressive disorder by Tan, Xiao Wei, Seow, Esmond, Abdin, Edimansyah, Verma, Swapna, Sim, Kang, Chong, Siow Ann, Subramaniam, Mythily

“…In this study, we aimed to compare the subjective quality of life (QoL) among patients with schizophrenia spectrum disorders and major depressive disorder (MDD). Methods: QoL scores were collected using 36-item Short Form Survey Instrument. …”
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Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews by Levis, Brooke, Benedetti, Andrea, Riehm, Kira E., Saadat, Nazanin, Levis, Alexander W., Azar, Marleine, Rice, Danielle B., Chiovitti, Matthew J., Sanchez, Tatiana A., Cuijpers, Pim, Gilbody, Simon, Ioannidis, John P. A., Kloda, Lorie A., McMillan, Dean, Patten, Scott B., Shrier, Ian, Steele, Russell J., Ziegelstein, Roy C., Akena, Dickens H., Arroll, Bruce, Ayalon, Liat, Baradaran, Hamid R., Baron, Murray, Beraldi, Anna, Bombardier, Charles H., Butterworth, Peter, Carter, Gregory, Chagas, Marcos H., Chan, Juliana C. N., Cholera, Rushina, Chowdhary, Neerja, Clover, Kerrie, Conwell, Yeates, de Man-van Ginkel, Janneke M., Delgadillo, Jaime, Fann, Jesse R, Fischer, Felix H, Fischler, Benjamin, Fung, Daniel, Gelaye, Bizu, Goodyear-Smith, Felicity, Greeno, Catherine G., Hall, Brian J., Hambridge, John, Harrison, Patricia A., Hegerl, Ulrich, Hides, Leanne, Hobfoll, Stevan E., Hudson, Marie, Hyphantis, Thomas, Inagaki, Masatoshi, Ismail, Khalida, Jetté, Nathalie, Khamseh, Mohammad E., Kiely, Kim M., Lamers, Femke, Liu, Shen-Ing, Lotrakul, Manote, Loureiro, Sonia R., Löwe, Bernd, Marsh, Laura, McGuire, Anthony, Mohd Sidik, Sherina, Munhoz, Tiago N., Muramatsu, Kumiko, Osório, Flávia L., Patel, Vikram, Pence, Brian W., Persoons, Philippe, Picardi, Angelo, Rooney, Alasdair G., Santos, Iná S., Shaaban, Juwita, Sidebottom, Abbey, Simning, Adam, Stafford, Lesley, Sung, Sharon, Tan, Lynnette Pei Lin, Turner, Alyna, van der Feltz-Cornelis, Christina M., van Weert, Henk C., Vöhringer, Paul A., White, Jennifer, Whooley, Mary A., Winkley, Kirsty, Yamada, Mitsuhiko, Zhang, Yuying, Thombs, Brett D.

“…It is not known whether interview method is associated with probability of major depression classification. Aims: To evaluate the association between interview method and odds of major depression classification, controlling for depressive symptom scores and participant characteristics. …”
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The impact of negative symptoms and neurocognition on functioning in MDD and schizophrenia by Quek, Yue Feng, Yang, Zixu, Dauwels, Justin, Lee, Jimmy

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Using interaction between cognitive and motor impairment for risk screening of major neurocognitive disorders: results of the EPIDOS observational cohort study by Beauchet, Olivier, Matskiv, Jacqueline, Rolland, Yves, Schott, Anne-Marie, Allali, Gilles

“…Background and purpose: Cognitive and motor impairments are risk factors of major neurocognitive disorders (MNCD). Inability to name the date and use of a walking aid and/or history of falls are two items which are surrogate measures of cognitive and motor impairments. …”
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Measuring upper limb function and patient reported outcomes after major breast cancer surgery : a pilot study in an Asian cohort by Chan, Kai Siang, Zeng, Ding, Leung, Joelle Hoi Ting, Ooi, Belinda Si Yin, Kong, Kit Teng, Yeo, Yi Heng, Goo, Jerry Tiong Thye, Chia, Clement Luck Khng

“…Majority of studies are conducted in Western population and may not be applicable to Asians. …”
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White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group by van Velzen, Laura S., Kelly, Sinead, Isaev, Dmitry, Aleman, Andre, Aftanas, Lyubomir I, Bauer, Jochen, Baune, Bernhard T., Brak, Ivan V., Carballedo, Angela, Connolly, Colm G., Couvy-Duchesne, Baptiste, Cullen, Kathryn R, Danilenko, Konstantin V, Dannlowski, Udo, Enneking, Verena, Filimonova, Elena, Förster, Katharina, Frodl, Thomas, Gotlib, Ian H., Groenewold, Nynke A., Grotegerd, Dominik, Harris, Mathew A., Hatton, Sean N., Hawkins, Emma L., Hickie, Ian B., Ho, Tiffany C., Jansen, Andreas, Kircher, Tilo, Klimes-Dougan, Bonnie, Kochunov, Peter, Krug, Axel, Lagopoulos, Jim, Lee, Renick, Lett, Tristram A., Li, Meng, MacMaster, Frank P., Martin, Nicholas G., McIntosh, Andrew M., McLellan, Quinn, Meinert, Susanne, Nenadić, Igor, Osipov, Evgeny, Penninx, Brenda W. J. H., Portella, Maria J., Repple, Jonathan, Roos, Annerine, Sacchet, Matthew D., Sämann, Philipp G., Schnell, Knut, Shen, Xueyi, Sim, Kang, Stein, Dan J., van Tol, Marie-Jose, Tomyshev, Alexander S., Tozzi, Leonardo, Veer, Ilya M., Vermeiren, Robert, Vives-Gilabert, Yolanda, Walter, Henrik, Walter, Martin, van der Wee, Nic J. A., van der Werff, Steven J. A., Schreiner, Melinda Westlund, Whalley, Heather C., Wright, Margaret J., Yang, Tony T., Zhu, Alyssa, Veltman, Dick J., Thompson, Paul M., Jahanshad, Neda, Schmaal, Lianne

“…Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. …”
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"Emergency Room Evaluation and Recommendations" (ER2) tool for the screening of older emergency department visitors with major neurocognitive disorders: results from the ER² database by Beauchet, Olivier, Cooper-Brown, Liam A., Lubov, Joshua, Allali, Gilles, Afilalo, Marc, Launay, Cyrille P.

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Emergency room evaluation and recommendations and risk screening of incident major neurocognitive disorders in older females: results of an observational population-based cohort study by Beauchet, Olivier, Matskiv, Jacqueline, Launay, Cyrille P., Rolland, Yves, Schott, Anne-Marie, Allali, Gilles

“…Background: “Emergency Room Evaluation and Recommendations” (ER2 ) risk levels (i.e., low, moderate and high) may be used to screen for major neurocognitive disorders (MNCD) in older emergency department users, as a high ER2 risk level is associated with MNCD diagnosis. …”
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Tuberculous meningitis is a major cause of mortality and morbidity in adults with central nervous system infections in Kota Kinabalu, Sabah, Malaysia: an observational study by Lee, Heng Gee, William, Timothy, Menon, Jayaram, Ralph, Anna P., Ooi, Eng Eong, Hou, Yan’an, Sessions, October, Yeo, Tsin Wen

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A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality by Holmkvist, P., Roepstorff, K., Uronen-Hansson, H., Sandén, C., Gudjonsson, S., Patschan, O., Grip, O., Marsal, J., Schmidtchen, A., Hornum, L., Erjefält, J. S., Håkansson, K., Agace, W W.

“…Mucosal tissues contain large numbers of memory CD4+ T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4+ T cells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) and death receptor-3 (DR3), and display innate lymphocyte functionality. …”
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Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma by Xiong, Zhewen, Chan, Stephen Lam, Zhou, Jingying, Vong, Joaquim S. L., Kwong, Tsz Tung, Zeng, Xuezhen, Wu, Haoran, Cao, Jianquan, Tu, Yalin, Feng, Yu, Yang, Weiqin, Wong, Patrick Pak-Chun, Si-Tou, Willis Wai-Yiu, Liu, Xiaoyu, Wang, Jing, Tang, Wenshu, Liang, Zhixian, Lu, Jiahuan, Li, Ka Man, Low, Jie-Ting, Chan, Michael Wing-Yan, Leung, Howard H. W., Chan, Anthony W. H., To, Ka-Fai, Yip, Kevin Yuk-Lap, Lo, Yuk Ming Dennis, Sung, Joseph Jao Yiu, Cheng, Alfred Sze-Lok

“…Therapy-induced tumour microenvironment (TME) remodelling poses a major hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed to investigate the mechanisms underlying tumour adaptation to immune-checkpoint targeting.…”
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An updated meta-analysis on the clinical outcomes of percutaneous left atrial appendage closure versus direct oral anticoagulation in patients with atrial fibrillation by Jiang, Haowen, Koh, Tian Hai, Vengkat, Vijay, Fei, Gao, Ding, Zee Pin, Ewe, See Hooi, Jappar, Ignasius, Lim, Soo Teik, Yap, Jonathan

“…The outcomes studied included the combined major adverse cardiovascular (CV) events outcomes, ischemic stroke and thromboembolic events, major bleeding, CV mortality, and all-cause mortality. …”
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Risk factors and treatment outcomes of severe Clostridioides difficile infection in Singapore by Tay, Hui Lin, Chow, Angela, Ng, Tat Ming, Lye, David C.

“…Treatment outcomes were (1) diarrhoea persistence, (2) CDI recurrence, (3) major complications despite treatment and (4) 30-day mortality. …”
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Feasibility of wastewater-based detection of emergent pandemics through a global network of airports by Jin, Shihui, Dickens, Borame L., Toh, Kai Yee, Lye, David Chien Boon, Lee, Vernon J., Cook, Alex R.

“…We also found other contributors to early detection, including high sampling proportion of inbound flight at destination airports, small population size of the epicentre relative to the travel volume, and large volume of outbound travelers to major airports around the globe. We concluded that routine aircraft wastewater monitoring could be a feasible approach for early identification and tracking of an emerging pathogen with high faecal shedding rates, particularly when implemented through a global surveillance network of major airports.…”
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Acute and subchronic exposure of cyadox induced metabolic and transcriptomic disturbances in Wistar rats by Huang, Chongyang, Lei, Hehua, Liu, Chaoyang, Wang, Yulan

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