Neurofilament light as a blood biomarker for neurodegeneration in down syndrome by Strydom, Andre, Heslegrave, Amanda, Startin, Carla M., Mok, Kin Y., Hardy, John, Groet, Jurgen, Nizetic, Dean, Zetterberg, Henrik

“…Conclusions NF-L is a biomarker for neurodegeneration in DS with potential for use in future clinical trials to prevent or delay dementia.…”
Get full text
Get full text

MED13 and glycolysis are conserved modifiers of α-synuclein-associated neurodegeneration by Ren, Mengda, Yang, Ying, Heng, Kelsey Hwee Yee, Ng, Lu Yi, Chong, Claris Yuin-Yi, Ng, Yan Ting, Gorur-Shandilya, Srinivas, Lee, Rachel Min Qi, Lim, Kah Leong, Zhang, Jing, Koh, Tong-Wey

“…The resulting neurodegeneration can be suppressed by overexpressing a glycolytic enzyme or treatment with deferoxamine, suggesting that compensatory glycolysis is neuroprotective. …”
Get full text

Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia by Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran

“…We examined amyloid-tau-neurodegeneration biomarker effects on cognition in a Southeast-Asian cohort of 84 sporadic young-onset dementia (YOD; age-at-onset <65 years) patients. …”
Get full text

The role of tyrosine hydroxylase-dopamine pathway in Parkinson's disease pathogenesis by Zhou, Zhi Dong, Saw, Wuan Ting, Ho, Patrick Ghim Hoe, Zhang, Zhi Wei, Zeng, Li, Chang, Ya Yin, Sun, Alfred Xu Yang, Ma, Dong Rui, Wang, Hong Yan, Zhou, Lei, Lim, Kah-Leong, Tan, Eng-King

Subjects: Get full text

Brief report : isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration by Murray, Aoife, Letourneau, Audrey, Canzonetta, Claudia, Stathaki, Elisavet, Gimelli, Stefania, Sloan-Bena, Frederique, Abrehart, Robert, Goh, Pollyanna, Lim, Shuhui, Baldo, Chiara, Dagna-Bricarelli, Franca, Hannan, Saad, Mortensen, Martin, Ballard, David, Syndercombe Court, Denise, Fusaki, Noemi, Hasegawa, Mamoru, Smart, Trevor G., Bishop, Cleo, Antonarakis, Stylianos E., Groet, Jürgen, Nizetic, Dean

“…DS is also a unique genetic system for investigation of pathological and protective mechanisms for accelerated ageing, neurodegeneration, dementia, cancer, and other important common diseases. …”
Get full text
Get full text

Mitochondrial regulation of microglial immunometabolism in Alzheimer’s disease by Fairley, Lauren H., Wong, Jia Hui, Barron, Anna M.

Subjects: Get full text

High diagnostic utility incorporating a targeted neurodegeneration gene panel with MRI brain diagnostic algorithms in patients with young-onset cognitive impairment with leukodystrophy by Chen, Zhiyong, Tan, Yi Jayne, Lian, Michelle Mulan, Tandiono, Moses, Foo, Jia Nee, Lim, Weng Khong, Kandiah, Nagaendran, Tan, Eng-King, Ng, Adeline S. L.

“…We performed sequencing using a custom-designed panel of 200 neurodegeneration-associated genes on 45 patients with young-onset cognitive impairment with leukodystrophy, and classified them based on van der Knaap et al.'…”
Get full text

Longitudinal analysis of retinal microvascular and choroidal imaging parameters in Parkinson's disease compared with controls by Kundu, Anita, Ma, Justin P., Robbins, Cason B., Pant, Praruj, Gunasan, Vithiya, Agrawal, Rupesh, Stinnett, Sandra, Scott, Burton L., Moore, Kathryn P. L., Fekrat, Sharon, Grewal, Dilraj S.

Subjects: Get full text

Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases by Lo, Chih Hung, Zeng, Jialiu

“…Similar lysosomal abnormalities are also present in sporadic forms of neurodegeneration, although the underlying pathogenic mechanisms are unclear and remain to be investigated. …”
Get full text

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice by Zhou, Libin, Flores, Joseph, Noël, Anastasia, Beauchet, Olivier, Sjöström, P. Jesper, LeBlanc, Andrea C.

“…Mice expressing human Caspase-6 in hippocampal CA1 neurons develop age-dependent cognitive deficits, neurodegeneration and neuroinflammation. This study assessed if methylene blue (MB), a phenothiazine that inhibits caspases, alters Caspase-6-induced neurodegeneration and cognitive impairment in mice. …”
Get full text

Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases by Kumar, Sundramurthy, Karthikeyan, Narayanan, Mishra, Sachin, Padmanabhan, Parasuraman, Radda, George, Gulyás, Balázs

“…The genetic and molecular origins of protein misfolding in association with their relationship with neurodegeneration and aging are being studied to better understand and develop treatments. …”
Get full text

Current and future trends in biomarkers for the early detection of Alzheimer's disease in Asia: expert opinion by Kandiah, Nagaendran, Choi, Seong Hye, Hu, Chaur-Jong, Ishii, Kenji, Kasuga, Kensaku, Mok, Vincent C. T.

“…The amyloid, tau, and neurodegeneration (AT[N]) framework, which classifies biomarkers by their core pathophysiological features, is a biomarker measure of amyloid plaques and neurofibrillary tangles. …”
Get full text

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer's disease by Asimakidou, Evridiki, Reynolds, Richard, Barron, Anna M., Lo, Chih Hung

“…By combining features of apoptosis and necrosis, necroptosis has been proposed to constitute a more comprehensive mechanistic explanation for neurodegeneration, which is less likely to occur by the immunologically silent apoptotic cell death or by the acute occurrence of necrosis after cellular stress (Jayaraman and Reynolds, 2022).…”
Get full text

Activation of autophagy ameliorates age-related neurogenesis decline and neurodysfunction in adult mice by Yang, Na, Liu, Xueqin, Niu, Xiaojie, Wang, Xiaoqiang, Jiang, Rong, Yuan, Na, Wang, Jianrong, Zhang, Chengwu, Lim, Kah-Leong, Lu, Li

“…However, this process declines with aging, which is implicated in the recession of brain function and neurodegeneration. Understanding the mechanism of adult neurogenesis and stimulating neurogenesis will benefit the mitigation of neurodegenerative diseases. …”
Get full text

A pair of siblings with Wolfram Syndrome: a review of the literature and treatment options by Png, Doanna, Yeoh, Ester, Tan, Clara, Lim, Su Chi

“…Wolfram syndrome (WS) is a rare genetic disorder typically characterized by juvenile onset diabetes mellitus, optic atrophy, hearing loss, diabetes insipidus, and neurodegeneration. There would be a high index of clinical suspicion for WS when clinical manifestations of type 1 diabetes and optic atrophy present together. …”
Get full text

The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms by Kovács, Tibor, Billes, Viktor, Komlós, Marcell, Hotzi, Bernadette, Manzéger, Anna, Tarnóci, Anna, Papp, Diána, Szikszai, Fanni, Szinyákovics, Janka, Rácz, Ákos, Noszál, Béla, Veszelka, Szilvia, Walter, Fruzsina R., Deli, Mária A., Hackler, Laszlo, Alfoldi, Robert, Huzian, Orsolya, Puskas, Laszlo G., Liliom, Hanna, Tárnok, Krisztián, Schlett, Katalin, Borsy, Adrienn, Welker, Ervin, Kovács, Attila L., Pádár, Zsolt, Erdős, Attila, Legradi, Adam, Bjelik, Annamaria, Gulya, Károly, Gulyás, Balázs, Vellai, Tibor

“…Defects in autophagy are implicated in the development of various age-dependent degenerative disorders such as cancer, neurodegeneration and tissue atrophy, and in accelerated aging. …”
Get full text
Get full text

Mitochondrial dysfunction and Parkinson’s disease — near-infrared photobiomodulation as a potential therapeutic strategy by Foo, Aaron Song Chuan, Soong, Tuck Wah, Yeo, Tseng Tsai, Lim, Kah-Leong

“…A recent approach towards forestalling dopaminergic neurodegeneration in PD involves near-infrared (NIR) photobiomodulation (PBM), which is thought to enhance mitochondrial function of stimulated cells through augmenting the activity of cytochrome C oxidase. …”
Get full text

In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [18F]MNI-659 by Svedberg, Marie M., Varnäs, Katarina, Varrone, Andrea, Mitsios, Nicholas, Mulder, Jan, Gulyás, Balázs, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Zaleska, Margaret M., Schmidt, Christopher J., Halldin, Christer, Mrzljak, Ladislav

“…Highly specific and sensitive biomarkers for pathologies related to dysfunctions in the basal ganglia circuit are of great value to assess therapeutic efficacy not only clinically to establish an early diagnosis, but also in terms of monitoring the efficacy of therapeutic interventions and decelerated neurodegeneration. The phosphodiesterase 10A (PDE10A) enzyme plays a central role in striatal signaling and is implicated in several neuropsychiatric disorders involving striatal pathology, such as Huntingtońs disease (HD) and schizophrenia. …”
Get full text

Differential effects of white matter hyperintensities and regional amyloid deposition on regional cortical thickness by Tan, Chin Hong, Chew, Justin, Zhang, Liwen, Gulyás, Balázs, Chen, Christopher

“…White matter hyperintensities (WMH) and β-amyloid (Aβ) accumulation have both been linked to neurodegeneration in Alzheimer's disease (AD). However, the independent effects of global WMH and regional Aβ on the corresponding regional cortical thickness have not been investigated. …”
Get full text

Lewy body-like inclusions in human midbrain organoids carrying glucocerebrosidase and α-synuclein mutations by Jo, Junghyun, Yang, Lin, Tran, Hoang-Dai, Yu, Weonjin, Sun, Alfred Xuyang, Chang, Ya Yin, Jung, Byung Chul, Lee, Seung-Jae, Saw, Tzuen Yih, Xiao, Bin, Khoo, Audrey Tze Ting, Yaw, Lai-Ping, Xie, Jessica Jiaxin, Lokman, Hidayat, Ong, Wei-Yi, Lim, Grace Gui Yin, Lim, Kah-Leong, Tan, Eng-King, Ng, Huck-Hui, Je, Hyunsoo Shawn

“…Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parkinson disease, with the particular aim of recapitulating α-syn– and Lewy body–related pathologies and the process of neurodegeneration in the hMLO model. Methods: We generated and characterized hMLOs from GBA1−/−and SNCA overexpressing isogenic embryonic stem cells and also generated Lewy body–like inclusions in GBA1/SNCA dual perturbation hMLOs and conduritol-b-epoxide–treated SNCA triplication hMLOs. …”
Get full text