Expression of Intermediate Filaments in the Developing Testis and Testicular Germ Cell Cancer by Maria E. Camacho-Moll, Leendert H. J. Looijenga, Roland Donat, Chitranjan J. Shukla, Anne Jørgensen, Rod T. Mitchell

“…Cytokeratin and desmin expression have been associated with Sertoli cell maturity and the development of testicular germ cell cancer (TGCC). Thus, the present study aimed to characterize the expression of these intermediate filaments in normal testis development and TGCC. …”
Get full text

Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence by Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda

“…Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. …”
Get full text

The Role of <i>TP53</i> in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors by Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga

Subjects: “…human malignant germ cell tumors…”
Get full text

<i>XIST</i>-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality by João Lobo, Sandra P. Nunes, Ad J. M. Gillis, Daniela Barros-Silva, Vera Miranda-Gonçalves, Annette van den Berg, Mariana Cantante, Rita Guimarães, Rui Henrique, Carmen Jerónimo, Leendert H. J. Looijenga

Subjects: Get full text

Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis by Dennis M. Timmerman, Tessa L. Remmers, Sanne Hillenius, Leendert H. J. Looijenga

“…This review provides a comprehensive overview of these factors that are known to deregulate the P53 pathway in both somatic and embryonic cells, as well as their malignant counterparts (i.e., somatic and germ cell tumors). It provides insights into which aspects still need to be unraveled to grasp their contribution to tumorigenesis, putatively leading to novel targets for effective cancer therapies.…”
Get full text

Recurrence of a Mediastinal Germ-Cell Tumor as a Somatic-Type Malignancy: A Complex Case Report by Caroline C. C. Hulsker, Mariëtte E. G. Kranendonk, Thomas F. Eleveld, Ad J. M. Gillis, Cornelis P. van de Ven, Natasha K. A. van Eijkelenburg, Niels P. van der Kaaij, Alida F. W. van der Steeg, Leendert H. J. Looijenga

Subjects: “…mediastinal germ-cell tumor…”
Get full text

Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors by João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Vera Miranda-Gonçalves, Vânia Camilo, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique, Carmen Jerónimo

Subjects: “…testicular germ cell tumors…”
Get full text

Treatment and Survival of Malignant Extracranial Germ Cell Tumours in the Paediatric Population: A Systematic Review and Meta-Analysis by Caroline C. C. Hulsker, Issam el Mansori, Marta Fiocco, József Zsiros, Marc H. W. Wijnen, Leendert H. J. Looijenga, Annelies M. C. Mavinkurve-Groothuis, Alida F. W. van der Steeg

Subjects: “…germ cell tumour…”
Get full text

CRIPTO and miR-371a-3p Are Serum Biomarkers of Testicular Germ Cell Tumors and Are Detected in Seminal Plasma from Azoospermic Males by Cassy M. Spiller, João Lobo, Willem P. A. Boellaard, Ad J. M. Gillis, Josephine Bowles, Leendert H. J. Looijenga

Subjects: Get full text

Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest by João Lobo, Ana Rita Cardoso, Vera Miranda-Gonçalves, Leendert H. J. Looijenga, Marie Lopez, Paola B. Arimondo, Rui Henrique, Carmen Jerónimo

Subjects: Get full text

miR-371a-3p, miR-373-3p and miR-367-3p as Serum Biomarkers in Metastatic Testicular Germ Cell Cancers Before, During and After Chemotherapy by Ximena Rosas Plaza, Ton van Agthoven, Coby Meijer, Marcel A. T. M. van Vugt, Steven de Jong, Jourik A. Gietema, Leendert H. J. Looijenga

Subjects: “…testicular germ cell cancer…”
Get full text

Combining Hypermethylated <i>RASSF1A</i> Detection Using ddPCR with miR-371a-3p Testing: An Improved Panel of Liquid Biopsy Biomarkers for Testicular Germ Cell Tumor Patients by João Lobo, Lieke M. J. van Zogchel, Mohammed G. Nuru, Ad J. M. Gillis, C. Ellen van der Schoot, Godelieve A. M. Tytgat, Leendert H. J. Looijenga

Subjects: “…germ cell tumors…”
Get full text

Comparative Analyses of Liquid-Biopsy MicroRNA371a-3p Isolation Protocols for Serum and Plasma by Dennis M. Timmerman, Ad J. M. Gillis, Michal Mego, Leendert H. J. Looijenga

“…The miR-371a-3 cluster members are an example, monitoring the presence of malignant germ cell tumors based on patient serum/plasma analyses. …”
Get full text