Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions. by Morgan, M, Mould, A, Li, L, Robertson, E, Bikoff, E

“…Its C-terminal zinc finger domain mediates nuclear import, DNA binding, and recruitment of the corepressors G9a and HDAC1/2. Alternatively spliced transcripts lacking exon 7 sequences encode a structurally divergent isoform (Blimp-1Δexon7) predicted to have distinct functions. …”

A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. by Yan, Z, Delannoy, M, Ling, C, Daee, D, Osman, F, Muniandy, P, Shen, X, Oostra, AB, Du, H, Steltenpool, J, Lin, T, Schuster, B, Décaillet, C, Stasiak, A, Stasiak, A, Stone, S, Hoatlin, M, Schindler, D, Woodcock, C, Joenje, H, Sen, R, de Winter, J, Li, L, Seidman, M, Whitby, M

“…In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. …”

Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transie... by Best, JG, Ambler, G, Wilson, D, Lee, K-J, Lim, J-S, Shiozawa, M, Li, L, Koga, M, Lovelock, C, Chabriat, H, Hennerici, M, Wong, YK, Mak, HKF, Prats-Sanchez, L, Martínez-Domeño, A, Inamura, S, Yoshifuji, K, Arsava, EM, Horstmann, S, Purrucker, J, Lam, BYK, Wong, A, Kim, YD, Song, T-J, Lemmens, R, Eppinger, S, Gattringer, T, Uysal, E, Tanriverdi, Z, Bornstein, NM, Ben Assayag, E, Hallevi, H, Molad, J, Nishihara, M, Tanaka, J, Coutts, SB, Polymeris, A, Wagner, B, Seiffge, DJ, Lyrer, P, Algra, A, Kappelle, LJ, Al-Shahi Salman, R, Jäger, HR, Lip, GYH, Fischer, U, El-Koussy, M, Mas, J-L, Legrand, L, Karayiannis, C

“…FINDINGS: The included studies recruited participants between Aug 28, 2001, and Feb 4, 2018. 15 766 participants had follow-up for intracranial haemorrhage, and 15 784 for ischaemic stroke. …”

Characteristics of spicy food consumption and its relation to lifestyle behaviours: results from 0.5 million adults by Wen, Q, Chen, Z, Wei, Y, Du, H, Lv, J, Guo, Y, Bian, Z, Yang, L, Chen, Y, Chen, Y, Shi, L, Chen, J, Yu, C, Li, L

“…<p>This study aimed to describe the characteristics and lifestyle differences of spicy food consumption in 0.5 million adults. Participants were recruited from 2004 to 2008 in the baseline research of the CKB study. …”

Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos by Li, L, Rispoli, R, Patient, R, Ciau-Uitz, A, Porcher, C

“…Etv6 also directly activates expression of the activator klf4; reflecting a genome-wide paucity in ETS-binding motifs in Etv6 genomic targets, Klf4 then recruits Etv6 to the vegfa promoter to activate its expression. …”

Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies by Traylor, M, Persyn, E, Tomppo, L, Klasson, S, Abedi, V, Bakker, MK, Torres, N, Li, L, Bell, S, Rutten-Jacobs, L, Tozer, DJ, Griessenauer, CJ, Zhang, Y, Pedersen, A, Sharma, P, Jimenez-Conde, J, Rundek, T, Grewal, RP, Lindgren, A, Meschia, JF, Salomaa, V, Havulinna, A, Kourkoulis, C, Crawford, K, Marini, S, Mitchell, BD, Kittner, SJ, Rosand, J, Dichgans, M, Jern, C, Strbian, D, Fernandez-Cadenas, I, Zand, R, Ruigrok, Y, Rost, N, Lemmens, R, Rothwell, PM, Anderson, CD, Wardlaw, J, Lewis, CM, Markus, HS, Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group, National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network, UK DNA Lacunar Stroke Study Investigators, International Stroke Genetics Consortium

“…Patients were recruited from hospitals in the UK as part of the UK DNA Lacunar Stroke studies 1 and 2 and from collaborators within the International Stroke Genetics Consortium. …”

Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study by Chan, KA, Wright, N, Xiao, D, Guo, Y, Chen, Y, Du, H, Yang, L, Millwood, IY, Pei, P, Wang, J, Turnbull, I, Gilbert, S, Avery, D, Kartsonaki, C, Yu, C, Chen, J, Lv, J, Clarke, R, Collins, R, Peto, R, Li, L, Wang, C, Chen, Z

“…They were invited and recruited between June 25, 2004, and July 15, 2008. …”

Epidemiological characteristics of domestic fuel use in adults in 10 regions of China by Li, J, Wu, M, Yu, C, Lyu, J, Guo, Y, Bian, Z, Tan, Y, Pei, P, Chen, J, Chen, Z, Cao, W, Li, L

“…Methods: The CKB study recruited 512 891 adults from 10 areas in China during 2004-2008. …”

Ipsilateral intracranial edema associated with drainage patterns of dural arteriovenous fistula. by Dong, Y, Cao, W, Huang, L, Li, L, Zhang, Y, Dong, Q, Zhang, X

“…METHODS: One hundred and two consecutive patients diagnosed with DAVF and admitted to the Huashan Hospital from 2006 to 2012 were retrospectively reviewed for the clinical and radiologic data, and those with ipsilateral edema were recruited. An edema scale was calculated from the locations with edema on magnetic resonance imaging. …”

生命早期饥荒暴露与成年期体质指数的关联分析 [Association between famine exposure during early life and BMI in adulthood] by Meng, R, Si, J, Lyu, J, Guo, Y, Bian, Z, Yu, C, Zhou, H, Tan, Y, Pei, P, Chen, J, Chen, Z, Li, L, China Kadoorie Biobank (CKB) Collaborative Group

“…Methods: A total of 94 052 participants recruited in the baseline survey of China Kadoorie Biobank were included in this study. …”

Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study. by Pardini, B, Verderio, P, Pizzamiglio, S, Nici, C, Maiorana, M, Naccarati, A, Vodickova, L, Vymetalkova, V, Veneroni, S, Daidone, MG, Ravagnani, F, Bianchi, T, Bujanda, L, Carracedo, A, Castells, A, Ruiz-Ponte, C, Morreau, H, Howarth, K, Jones, A, Castellví-Bel, S, Li, L, Tomlinson, I, Van Wezel, T, Vodicka, P, Radice, P

“…In the study, the variant -652 6N del was genotyped in a total of 6,733 CRC cases and 7,576 controls recruited by six different centers located in Spain, Italy, USA, England, Czech Republic and the Netherlands collaborating to the international consortium COGENT (COlorectal cancer GENeTics). …”

China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up. by Chen, Z, Chen, J, Collins, R, Guo, Y, Peto, R, Wu, F, Li, L

“…RESULTS: Overall, 512,891 adults aged 30-79 years were recruited, including 41% men, 56% from rural areas and mean age was 52 years. …”

Outdoor temperature, blood pressure, and cardiovascular disease mortality among 23 000 individuals with diagnosed cardiovascular diseases from China by Yang, L, Li, L, Lewington, S, Guo, Y, Sherliker, P, Bian, Z, Collins, R, Peto, R, Liu, Y, Yang, R, Zhang, Y, Li, G, Liu, S, Chen, Z

“…However, there are still limited data about seasonal variation in blood pressure and CVD mortality among patients with prior-CVD.We analysed data on 23 000 individuals with prior-CVD who were recruited from 10 diverse regions into the China Kadoorie Biobank during 2004-8. …”

Family history, waist circumference and risk of ischemic stroke: a prospective cohort study among Chinese adults by Liu, L, Xue, X, Zhang, H, Tian, X, Chen, Y, Guo, Y, Pei, P, Wang, S, Duan, H, Gao, R, Pang, Z, Chen, Z, Li, L

“…METHODS AND RESULTS: The China Kadoorie Biobank (CKB) study recruited 35,508 participants aged 30-79 years from the Qingdao urban area during 2004-2008. …”

Adiposity in relation to risks of fatty liver, cirrhosis and liver cancer: a prospective study of 0.5 million Chinese adults by Pang, Y, Kartsonaki, C, Turnbull, I, Guo, Y, Chen, Y, Clarke, R, Bian, Z, Bragg, F, Millwood, I, Yang, L, Huang, Y, Yang, Y, Zhang, X, Chen, J, Li, L, Holmes, M, Chen, Z

“…The prospective China Kadoorie Biobank recruited 512,891 adults aged 30–79 years from 10 areas. …”

Exhaled carbon monoxide and its associations with smoking, indoor household air pollution and chronic respiratory diseases among 512,000 Chinese adults. by Zhang, Q, Li, L, Smith, M, Guo, Y, Whitlock, G, Bian, Z, Kurmi, O, Collins, R, Chen, J, Lv, S, Pang, Z, Chen, C, Chen, N, Xiong, Y, Peto, R, Chen, Z, Chen, A

“…METHODS: The China Kadoorie Biobank includes 512,000 participants aged 30-79 years recruited from 10 diverse regions. We used linear regression and logistic regression methods to assess the associations of COex level with smoking, exposures to indoor household air pollution and prevalent chronic respiratory conditions among never smokers, both overall and by seasons, regions and smoking status. …”

Use of drug treatment for secondary prevention of cardiovascular disease in urban and rural communities of China: China Kadoorie Biobank Study of 0.5 million people. by Chen, Y, Li, L, Zhang, Q, Clarke, R, Chen, J, Guo, Y, Bian, Z, Pan, X, Peto, R, Tao, R, Shi, K, Collins, R, Ma, L, Sun, H, Chen, Z

“…METHODS AND RESULTS: We analysed cross-sectional data from the China Kadoorie Biobank (CKB) of 512,891 adults aged 30-79 years recruited from 1737 rural and urban communities in China. …”

Cancer incidence and mortality: A cohort study in China, 2008-2013 by Pan, R, Zhu, M, Yu, C, Lv, J, Guo, Y, Bian, Z, Yang, L, Chen, Y, Hu, Z, Chen, Z, Li, L, Shen, H, China Kadoorie Biobank Collaborative Group

“…A total of 497,693 cancer-free participants aged 35-74 years were recruited and successfully followed up from 2004 to 2013 in 5 urban and 5 rural areas across China. …”

Temporal trends of main reproductive characteristics in ten urban and rural regions of China: the China Kadoorie Biobank study of 300 000 women. by Lewington, S, Li, L, Murugasen, S, Hong, L, Yang, L, Guo, Y, Bian, Z, Collins, R, Chen, J, He, H, Wu, M, He, T, Ren, X, Meng, J, Peto, R, Chen, Z

“…METHODS: We examined the cross-sectional data from the China Kadoorie Biobank cohort study that recruited 300 000 women born between 1930 and 1974 (mean age: 51 years) from 10 socially diverse urban and rural regions of China. …”

Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank. by Lewington, S, Li, L, Sherliker, P, Guo, Y, Millwood, I, Bian, Z, Whitlock, G, Yang, L, Collins, R, Chen, J, Wu, X, Wang, S, Hu, Y, Jiang, L, Yang, L, Lacey, B, Peto, R, Chen, Z

“…METHODS: To investigate the relationship of blood pressure with season and outdoor temperature, we analysed cross-sectional data from the China Kadoorie Biobank study of 506,673 adults aged 30-79 years recruited from 10 diverse urban and rural regions in China. …”