MORU Tropical Health Network annual report 2021 by Day, N, Dondorp, AM, Limmathurotsakul, D, Maude, R, Tarning, J, Cheah, PY, Pan-ngum, W, White, NJ, Fegen, G, Burton, D, Nosten, F, Ashley, EA, Turner, P, Smithuis, F, Newton, PM, Fanello, C, Bleho, J

Management and outcomes of severe dengue patients presenting with sepsis in a tropical country. by Teparrukkul, P, Hantrakun, V, Day, N, West, T, Limmathurotsakul, D

“… <h4>Background</h4> <p>Dengue is a common cause of infection in adults in tropical countries. Sepsis is a syndrome of systemic manifestations induced by infection of any organisms; including bacterial, fungal and viral agents. …”

A call to action: time to recognise melioidosis as a neglected tropical disease by Savelkoel, J, Dance, DAB, Currie, BJ, Limmathurotsakul, D, Wiersinga, WJ

“…Melioidosis is a tropical infection caused by the soil bacterium Burkholderia pseudomallei. …”

Staphylococcus aureus bacteraemia in a tropical setting: Patient outcome and impact of antibiotic resistance by Nickerson, E, Hongsuwan, M, Limmathurotsakul, D, Wuthiekanun, V, White, N, Chierakul, W, Day, N, Peacock, S, Shah, K, Fowler, V, Srisomang, P, Mahavanakul, W, Wacharaprechasgul, T, West, T, Teerawatanasuk, N, Becher, H

“…There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus infection in the tropics. Methods: A prospective, observational study of S. aureus bacteraemia was conducted in a 1000-bed regional hospital in northeast Thailand over 1 year. …”

Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance by Nickerson, E, Hongsuwan, M, Limmathurotsakul, D, Wuthiekanun, V, Shah, K, Srisomang, P, Mahavanakul, W, Wacharaprechasgul, T, Fowler, V, West, T, Teerawatansauk, N, Becher, H, White, N, Chierakul, W, Day, N, Peacock, S

Subjects:

Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance. by Nickerson, E, Hongsuwan, M, Limmathurotsakul, D, Wuthiekanun, V, Shah, K, Srisomang, P, Mahavanakul, W, Wacharaprechasgul, T, Fowler, V, West, T, Teerawatanasuk, N, Becher, H, White, N, Chierakul, W, Day, N, Peacock, S

“…There are considerable knowledge gaps in epidemiology, treatment, drug resistance and outcome of invasive S. aureus infection in the tropics. METHODS: A prospective, observational study of S. aureus bacteraemia was conducted in a 1000-bed regional hospital in northeast Thailand over 1 year. …”

Strategies to reduce mortality from bacterial sepsis in adults in developing countries by Cheng, A, West, T, Limmathurotsakul, D, Peacock, S

Subjects:

Misidentification of Burkholderia pseudomallei as Acinetobacter species in northern Thailand by Greer, R, Wangrangsimakul, T, Amornchai, P, Wuthiekanun, V, Laongnualpanich, A, Dance, D, Limmathurotsakul, D

“…<p><strong>Background</strong> Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic throughout the tropics.</p> <p><strong>Methods</strong> A study of reported Acinetobacter spp. bacteraemia was performed at Chiang Rai provincial hospital from 2014 to 2015. …”

Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009 : a longitudinal study by Cooper, B, Kotirum, S, Kulpeng, W, Praditsitthikorn, N, Chittaganpitch, M, Limmathurotsakul, D, Day, N, Coker, R, Teerawattananon, Y, Meeyai, A

“…Influenza epidemiology differs substantially in tropical and temperate zones, but estimates of seasonal influenza mortality in developing countries in the tropics are lacking. …”

A retrospective analysis of melioidosis in Cambodian children, 2009-2013. by Turner, P, Kloprogge, S, Miliya, T, Soeng, S, Tan, P, Sar, P, Yos, P, Moore, C, Wuthiekanun, V, Limmathurotsakul, D, Turner, C, Day, N, Dance, D

“…Background<br/> Melioidiosis, infection by Burkholderia pseudomallei, is an important but frequently under-recognised cause of morbidity and mortality in Southeast Asia and elsewhere in the tropics. Data on the epidemiology of paediatric melioidosis in Cambodia are extremely limited. …”

Burkholderia pseudomallei and melioidosis by Meumann, EM, Limmathurotsakul, D, Dunachie, SJ, Wiersinga, WJ, Currie, BJ

“…Burkholderia pseudomallei, the causative agent of melioidosis, is found in soil and water of tropical and subtropical regions globally. Modelled estimates of the global burden predict that melioidosis remains vastly under-reported, and a call has been made for it to be recognized as a neglected tropical disease by the World Health Organization. …”

Human immune responses to melioidosis and cross-reactivity to low-virulence burkholderia species, Thailand1. by Rongkard, P, Kronsteiner, B, Hantrakun, V, Jenjaroen, K, Sumonwiriya, M, Chaichana, P, Chumseng, S, Chantratita, N, Wuthiekanun, V, Fletcher, HA, Teparrukkul, P, Limmathurotsakul, D, Day, NPJ, Dunachie, SJ

“…Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. …”

Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei by Chewapreecha, C, Mather, AE, Harris, SR, Hunt, M, Holden, MTG, Chaichana, C, Wuthiekanun, V, Dougan, G, Day, NPJ, Limmathurotsakul, D, Parkhill, J, Peacock, SJ

“…The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. …”

Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei by Chewapreecha, C, Mather, AE, Harris, SR, Hunt, M, Holden, MTG, Chaichana, C, Wuthiekanun, V, Dougan, G, Day, NPJ, Limmathurotsakul, D, Parkhill, J, Peacock, SJ

“…The environmental bacterium Burkholderia pseudomallei causes melioidosis, an important endemic human disease in tropical and sub-tropical countries. This bacterium occupies broad ecological niches including soil, contaminated water, single-cell microbes, plants and infection in a range of animal species. …”

Short report: Consensus guidelines for dosing of amoxicillin-clavulanate in melioidosis by Cheng, A, Chierakul, W, Chaowagul, W, Chetchotisakd, P, Limmathurotsakul, D, Dance, D, Peacock, S, Currie, B

“…Copyright © 2008 by The American Society of Tropical Medicine and Hygiene.…”

Short Report: Patterns of Organ Involvement in Recurrent Melioidosis by Limmathurotsakul, D, Chaowagul, W, Day, N, Peacock, S

“…Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.…”

Global burden and challenges of melioidosis by Dance, D, Limmathurotsakul, D

“…Described over 100 years ago by Alfred Whitmore in Rangoon, the disease is so neglected that it is not even on any of the lists of neglected tropical diseases, despite the fact that it probably kills more people each year than diseases that are much better known, such as leptospirosis and dengue. …”

Global burden of melioidosis in 2015: a systematic review and data synthesis by Birnie, E, Virk, H, Savelkoel, J, Spijker, R, Bertherat, E, Dance, D, Limmathurotsakul, D, Devleesschauwer, B, Haagsma, J, Wiersinga, W

“…It is often fatal, with a high prevalence in tropical areas. Clinical presentation can vary from abscess formation to pneumonia and sepsis. …”

Short report: Quantitation of B. pseudomallei in clinical samples by Wuthiekanun, V, Limmathurotsakul, D, Wongsuvan, G, Chierakul, W, Teerawattanasook, N, Teparrukkul, P, Day, N, Peacock, S

“…Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.…”

Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice. by West, T, Myers, N, Limmathurotsakul, D, Liggitt, H, Chantratita, N, Peacock, S, Skerrett, S

“…Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte Burkholderia pseudomallei. …”