The role of ASPP2 in intestinal cell polarity and homeostasis by Morato Koch, S

“…Recent evidence has linked intestinal homeostasis with cell polarity. ASPP2, a known tumor suppressor, has been implicated in the maintenance of epithelial integrity. …”

Epithelial cell polarity: A major gatekeeper against cancer by Royer, C, Lu, X

“…The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. …”

Epithelial cell polarity: a major gatekeeper against cancer? by Royer, C, Lu, X

“…The correct establishment and maintenance of cell polarity are crucial for normal cell physiology and tissue homeostasis. …”

The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity by Sottocornola, R

“…Since several tumour suppressors have been identified to be major players in cell polarity, and a loss of polarisation is a hallmark of cancer, the ability of ASPP2 to maintain cell polarity may further contribute towards its tumour suppressive function.…”

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. by Kim, H, Claps, G, Möller, A, Bowtell, D, Lu, X, Ronai, Z

“…In all, our studies demonstrate the role of Siah2 in regulation of TJ integrity and cell polarity under hypoxia, through its regulation of ASPP2 stability.…”

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. by Turnquist, C, Wang, Y, Severson, D, Zhong, S, Sun, B, Ma, J, Constaninescu, SN, Ansorge, O, Stolp, H, Molnár, Z, Szele, F, Lu, X

“…Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. …”

CagA-ASPP2 complex mediates loss of cell polarity and favours H.pylori colonisa-tion of human gastric organoids by Buti, L, Ruiz-Puig, C, Sangberg, D, Leissing, T, Brewer, RC, Owen, RP, Sgromo, B, Royer, C, Ebner, D, Lu, X

“…However, the mechanism by which CagA disrupts gastric epithelial cell polarity to achieve its oncogenicity is not fully understood. …”

ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development. by Sottocornola, R, Royer, C, Vives, V, Tordella, L, Zhong, S, Wang, Y, Ratnayaka, I, Shipman, M, Cheung, A, Gaston-Massuet, C, Ferretti, P, Molnár, Z, Lu, X

“…Cell polarity plays a key role in the development of the central nervous system (CNS). …”

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. by Wang, Y, Bu, F, Royer, C, Serres, S, Larkin, JR, Soto, MS, Sibson, N, Salter, V, Fritzsche, F, Turnquist, C, Koch, S, Zak, J, Zhong, S, Wu, G, Liang, A, Olofsen, P, Moch, H, Hancock, D, Downward, J, Goldin, R, Zhao, J, Tong, X, Guo, Y, Lu, X

“…Hence, ASPP2 is a key regulator of epithelial plasticity that connects cell polarity to the suppression of WNT signalling, EMT and tumour metastasis.…”

The role of ASPP2 in intestinal homeostasis and tumourigenesis by Qin, X

“…ASPP2, a member of the ASPP (apoptosis stimulating protein of p53) protein family, has been shown to act as a regulator of epithelial cell polarity and tumour suppressor. This study investigated whether the dual function of ASPP2 is involved in the regulation of intestinal homeostasis and tumourigenesis, with a particular interest in the distinction between epithelial cell autonomous and non-autonomous mechanisms.…”