New Diarylamine K_V10.1 Inhibitors and Their Anticancer Potential by Špela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin Mašič, Tihomir Tomašič

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Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K_V10.1 Pore Blockers by Žan Toplak, Franci Merzel, Luis A. Pardo, Lucija Peterlin Mašič, Tihomir Tomašič

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3D Pharmacophore-Based Discovery of Novel K_V10.1 Inhibitors with Antiproliferative Activity by Žan Toplak, Louise Antonia Hendrickx, Špela Gubič, Štefan Možina, Bojana Žegura, Alja Štern, Matjaž Novak, Xiaoyi Shi, Steve Peigneur, Jan Tytgat, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič

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Structure-Function Studies of Sponge-Derived Compounds on the Cardiac Ca_V3.1 Channel by Anne-Sophie Depuydt, Piyush A. Patel, Žan Toplak, Chinmaya Bhat, Manuela Voráčová, Irene Eteläinen, Fiammetta Vitulano, Tanja Bruun, Antti Lempinen, Nives Hribernik, Eero Mäki-Lohiluoma, Louise Hendrickx, Ernesto Lopes Pinheiro-Junior, Tihomir Tomašič, Lucija Peterlin Mašič, Jari Yli-Kauhaluoma, Paula Kiuru, Jan Tytgat, Steve Peigneur

“…A selectivity screening showed that these analogs are also active on hERG channels. Collectively, a new class of Ca_V3 channel inhibitors has been discovered and the structure–function studies provide new insights into the synthetic design of drugs and the mechanism of interaction with T-type Ca_V channels.…”
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