The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease. by Trachtenberg, A, Filippini, N, Cheeseman, J, Duff, E, Neville, M, Ebmeier, K, Karpe, F, Mackay, C

The effects of APOE on brain activity do not simply reflect the risk of Alzheimer's disease by Trachtenberg, A, Filippini, N, Cheeseman, J, Duff, E, Neville, M, Ebmeier, K, Karpe, F, Mackay, C

Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. by Filippini, N, MacIntosh, B, Hough, MG, Goodwin, G, Frisoni, G, Smith, S, Matthews, P, Beckmann, C, Mackay, C

“…We investigated structural and functional effects of the APOE polymorphism in 18 young healthy APOE epsilon4-carriers and 18 matched noncarriers (age range: 20-35 years). Brain activity was studied both at rest and during an encoding memory paradigm using blood oxygen level-dependent fMRI. …”

Using MRI to measure drug action: caveats and new directions. by Murphy, SE, Mackay, C

“…Investigating pharmacological modulation of brain activity using magnetic resonance imaging (MRI) presents an exciting opportunity to bridge the gap between preclinical and clinical studies, and holds the potential to be a useful tool in the discovery and development of novel therapeutic agents. …”

The effects of APOE-ε4 on the BOLD response. by Trachtenberg, A, Filippini, N, Mackay, C

“…While most studies report a significant difference in brain activity between carriers and noncarriers of the ε4 allele, there are inconsistencies in the direction and location of change. …”

First steps in using machine learning on fMRI data to predict intrusive memories of traumatic film footage. by Clark, I, Niehaus, K, Duff, E, Simplicio, D, Clifford, G, Smith, S, Mackay, C, Woolrich, M, Holmes, E

“…Results showed widespread increases in brain activation at encoding when viewing a scene in the scanner that would later return as an intrusive memory in the real world. …”

Task-driven ICA feature generation for accurate and interpretable prediction using fMRI. by Duff, E, Trachtenberg, A, Mackay, C, Howard, M, Wilson, F, Smith, S, Woolrich, M

“…Functional Magnetic Resonance Imaging (fMRI) shows significant potential as a tool for predicting clinically important information such as future disease progression or drug effect from brain activity. Multivariate techniques have been developed that combine fMRI signals from across the brain to produce more robust predictive capabilities than can be obtained from single regions. …”

First steps in using machine learning on fMRI data to predict intrusive memories of traumatic film footage by Clark, I, Niehaus, K, Duff, E, Simplicio, D, Clifford, G, Smith, S, Mackay, C, Woolrich, M, Holmes, E

“…Results showed widespread increases in brain activation at encoding when viewing a scene in the scanner that would later return as an intrusive memory in the real world. …”

Genetic risk and resilience for Alzheimer’s disease: The effect of the three APOE alleles on brain function across life by Suri, S

“…Notably, similar increases in brain activity were observed within the hippocampus during a memory-encoding task in young ε4 carriers relative to non-carriers, suggesting a link between ε4 and early-life functional hyperactivity. …”

The neural basis of flashback formation: the impact of viewing trauma. by Bourne, C, Mackay, C, Holmes, E

“…Using a novel prospective fMRI design, we compared brain activation for those film scenes that subsequently induced flashbacks with both non-traumatic control scenes and scenes with traumatic content that did not elicit flashbacks ('potentials'). …”

The neural basis of flashback formation: The impact of viewing trauma by Bourne, C, Mackay, C, Holmes, E

“…Using a novel prospective fMRI design, we compared brain activation for those film scenes that subsequently induced flashbacks with both non-traumatic control scenes and scenes with traumatic content that did not elicit flashbacks ('potentials'). …”

Neuroanatomy of impaired self-awareness in Alzheimer's disease and mild cognitive impairment. by Zamboni, G, Drazich, E, McCulloch, E, Filippini, N, Mackay, C, Jenkinson, M, Tracey, I, Wilcock, G

“…Imaging results showed a significant group-by-condition interaction in brain activation in medial prefrontal and anterior temporal regions, with AD patients showing significantly decreased activation in these regions only for the Self condition. …”

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest. by Tunbridge, E, Farrell, S, Harrison, P, Mackay, C

“…The results suggest that genotype-related differences in prefrontal dopaminergic tone result in neuroadaptive changes in basal functional connectivity, potentially including subtle COMT genotype-dependent differences in the relative coupling of task-positive and task-negative regions, which could in turn contribute to its effects on brain activation, connectivity, and behaviour.…”

Neuroanatomy of impaired self-awareness in Alzheimer's disease and mild cognitive impairment by Zamboni, G, Drazich, E, McCulloch, E, Filippini, N, Mackay, C, Jenkinson, M, Tracey, I, Wilcock, G

“…Results: Behavioural results showed that AD patients had significantly higher "Self discrepancy scores" than controls and MCI patients, whereas there were no significant differences between groups for "Other discrepancy scores" Imaging results showed a significant group-by-condition interaction in brain activation in medial prefrontal and anterior temporal regions, with AD patients showing significantly decreased activation in these regions only for the Self condition. …”