The Effect of Low Doses of Zearalenone (ZEN) on the Bone Marrow Microenvironment and Haematological Parameters of Blood Plasma in Pre-Pubertal Gilts by Magdalena Mróz, Magdalena Gajęcka, Katarzyna E. Przybyłowicz, Tomasz Sawicki, Sylwia Lisieska-Żołnierczyk, Łukasz Zielonka, Maciej Tadeusz Gajęcki

“…The aim of this study was to determine whether low doses of zearalenone (ZEN) influence the carry-over of ZEN and its metabolites to the bone marrow microenvironment and, consequently, haematological parameters. …”
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Effects of Deoxynivalenol and Zearalenone on the Histology and Ultrastructure of Pig Liver by Natalia Skiepko, Barbara Przybylska-Gornowicz, Magdalena Gajęcka, Maciej Gajęcki, Bogdan Lewczuk

“…Animals in the experimental groups received DON at a dose of 12 μg/kg body weight (BW) per day, ZEN at 40 μg/kg BW per day, or a mixture of DON (12 μg/kg BW per day) and ZEN (40 μg/kg BW). …”
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Imbalance in the Blood Concentrations of Selected Steroids in Pre-pubertal Gilts Depending on the Time of Exposure to Low Doses of Zearalenone by Anna Rykaczewska, Magdalena Gajęcka, Ewa Onyszek, Katarzyna Cieplińska, Michał Dąbrowski, Sylwia Lisieska-Żołnierczyk, Maria Bulińska, Andrzej Babuchowski, Maciej T. Gajęcki, Łukasz Zielonka

“…The experiment was performed on 60 clinically healthy gilts with average BW of 14.5 ± 2 kg, divided into three experimental groups and a control group. Group ZEN5 animals were orally administered ZEN at 5 μg ZEN/kg BW, group ZEN10 — at 10 μg ZEN/kg BW, group ZEN15 — at 15 μg ZEN/kg BW, whereas group C received a placebo. …”
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Carry-Over of Zearalenone and Its Metabolites to Intestinal Tissues and the Expression of CYP1A1 and GSTπ1 in the Colon of Gilts before Puberty by Magdalena Mróz, Magdalena Gajęcka, Paweł Brzuzan, Sylwia Lisieska-Żołnierczyk, Dawid Leski, Łukasz Zielonka, Maciej T. Gajęcki

“…The objective of this study was to evaluate whether low doses of zearalenone (ZEN) affect the carry-over of ZEN and its metabolites to intestinal tissues and the expression of CYP1A1 and GSTπ1 in the large intestine. …”
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Correlations between Low Doses of Zearalenone, Its Carryover Factor and Estrogen Receptor Expression in Different Segments of the Intestines in Pre-Pubertal Gilts—A Study Protocol... by Magdalena Gajęcka, Magdalena Mróz, Paweł Brzuzan, Ewa Onyszek, Łukasz Zielonka, Karolina Lipczyńska-Ilczuk, Katarzyna E. Przybyłowicz, Andrzej Babuchowski, Maciej T. Gajęcki

“…Group ZEN5 will be administered <i>per os</i> 5 μg ZEN/kg BW (MABEL), group ZEN10—10 μg ZEN/kg BW (NOAEL), and group ZEN15—15 µg ZEN/kg BW (low LOAEL). …”
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Time-Dependent Changes in the Intestinal Microbiome of Gilts Exposed to Low Zearalenone Doses by Katarzyna Cieplińska, Magdalena Gajęcka, Michał Dąbrowski, Anna Rykaczewska, Sylwia Lisieska-Żołnierczyk, Maria Bulińska, Łukasz Zielonka, Maciej T. Gajęcki

“…The experiment was performed on 60 clinically healthy gilts with average BW of 14.5 &#177; 2 kg, divided into three experimental groups and a control group. Group ZEN5 animals were orally administered ZEN at 5 &#956;g /kg BW, group ZEN10&#8212;10 &#956;g ZEN/kg BW and group ZEN15&#8212;15 &#181;g ZEN/kg BW. …”
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Exposure to Low Zearalenone Doses and Changes in the Homeostasis and Concentrations of Endogenous Hormones in Selected Steroid-Sensitive Tissues in Pre-Pubertal Gilts by Magdalena Gajęcka, Łukasz Zielonka, Andrzej Babuchowski, Maciej Tadeusz Gajęcki

“…This study was undertaken to analyze whether prolonged exposure to low-dose zearalenone (ZEN) mycotoxicosis affects the concentrations of ZEN, α-zearalenol (α-ZEL), and β-zearalenol (β-ZEL) in selected reproductive system tissues (ovaries, uterine horn—ovarian and uterine sections, and the middle part of the cervix), the hypothalamus, and pituitary gland, or the concentrations of selected steroid hormones in pre-pubertal gilts. …”
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The Effect of Different Doses of Zearalenone in Feed on the Bioavailability of Zearalenone and Alpha-Zearalenol, and the Concentrations of Estradiol and Testosterone in the Periphe... by Łukasz Zielonka, Magdalena Gajęcka, Sylwia Lisieska-Żołnierczyk, Michał Dąbrowski, Maciej T. Gajęcki

“…The objective of this study was to determine the effect of long-term (48 days), <i>per os</i> administration of specific zearalenone (ZEN) doses (20 and 40 &#956;g ZEN/kg BW in experimental groups EI and EII, which were equivalent to 200% and 400% of the upper range limit of the no-observed-adverse-effect-level (NOAEL), respectively) on the bioavailability of ZEN and the rate of changes in estradiol and testosterone concentrations in the peripheral blood of pre-pubertal gilts. …”
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A Cohort Study Investigating Zearalenone Concentrations and Selected Steroid Levels in Patients with Sigmoid Colorectal Cancer or Colorectal Cancer by Sylwia Lisieska-Żołnierczyk, Magdalena Gajęcka, Michał Dąbrowski, Łukasz Zielonka, Maciej T. Gajęcki

“…The aim: In this study was to determine if sigmoid colorectal cancer (SCC) and colorectal cancer (CRC) in women (W) and men (M) is accompanied by zearalenone (ZEN) mycotoxicosis and changes in selected steroid levels. …”
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Concentration of Zearalenone, Alpha-Zearalenol and Beta-Zearalenol in the Myocardium and the Results of Isometric Analyses of the Coronary Artery in Prepubertal Gilts by Magdalena Gajęcka, Michał S. Majewski, Łukasz Zielonka, Waldemar Grzegorzewski, Ewa Onyszek, Sylwia Lisieska-Żołnierczyk, Jerzy Juśkiewicz, Andrzej Babuchowski, Maciej T. Gajęcki

“…The carry-over of zearalenone (ZEN) to the myocardium and its effects on coronary vascular reactivity in vivo have not been addressed in the literature to date. …”
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The Effects of Deoxynivalenol and Zearalenone on the Pig Large Intestine. A Light and Electron Microscopy Study by Barbara Przybylska-Gornowicz, Bogdan Lewczuk, Magdalena Prusik, Maria Hanuszewska, Marcela Petrusewicz-Kosińska, Magdalena Gajęcka, Łukasz Zielonka, Maciej Gajęcki

“…Administration of toxins did not influence the architecture of the mucosa and submucosa in the large intestine. ZEN and ZEN + DON significantly decreased the number of goblet cells in the cecum and descending colon. …”
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Occurrence of Zearalenone and Its Metabolites in the Blood of High-Yielding Dairy Cows at Selected Collection Sites in Various Disease States by Wojciech Barański, Magdalena Gajęcka, Łukasz Zielonka, Magdalena Mróz, Ewa Onyszek, Katarzyna E. Przybyłowicz, Arkadiusz Nowicki, Andrzej Babuchowski, Maciej T. Gajęcki

“…Zearalenone (ZEN) and its metabolites, alpha-zearalenol (α-ZEL) and beta-zearalenol (<i>β</i>-ZEL), are ubiquitous in plant materials used as feed components in dairy cattle diets. …”
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Immunohistochemical Expression (IE) of Oestrogen Receptors in the Intestines of Prepubertal Gilts Exposed to Zearalenone by Magdalena Gajęcka, Iwona Otrocka-Domagała, Paweł Brzuzan, Michał Dąbrowski, Sylwia Lisieska-Żołnierczyk, Łukasz Zielonka, Maciej Tadeusz Gajęcki

“…Group E (experimental group; n = 18) gilts were dosed orally with 40 μg ZEN /kg body weight (BW), each day before morning feeding. …”
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Activity of Zearalenone in the Porcine Intestinal Tract by Magdalena Gajęcka, Łukasz Zielonka, Maciej Gajęcki

“…This study demonstrates that low doses (somewhat above the No Observed Adverse Effect Level, NOAEL) of the mycoestrogen zearalenone (ZEN) and its metabolites display multispecificity towards various biological targets in gilts. …”
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The Effect of Zearalenone on the Cytokine Environment, Oxidoreductive Balance and Metabolism in Porcine Ileal Peyer’s Patches by Kazimierz Obremski, Wojciech Trybowski, Paweł Wojtacha, Magdalena Gajęcka, Józef Tyburski, Łukasz Zielonka

“…The study demonstrated that ZEN doses corresponding to 50%, 100%, and 150% of NOAEL values, i.e., 5 µg, 10 µg, and 15 µg ZEN/kg BW, respectively, have proinflammatory properties, exacerbate oxidative stress responses, and disrupt basal metabolism in ileal Payer’s patches in gilts.…”
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