Glycine Transporter 1 Inhibitors: Predictions on Their Possible Mechanisms in the Development of Opioid Analgesic Tolerance by Anna Rita Galambos, Zsolt Tamás Papp, Imre Boldizsár, Ferenc Zádor, László Köles, Laszlo G. Harsing, Mahmoud Al-Khrasani

Subjects: “…opioid analgesic tolerance…”
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Telmisartan Is a Promising Agent for Managing Neuropathic Pain and Delaying Opioid Analgesic Tolerance in Rats by David Á. Karádi, Anna Rita Galambos, Péter P. Lakatos, Joost Apenberg, Sarah K. Abbood, Mihály Balogh, Kornél Király, Pál Riba, Nariman Essmat, Edina Szűcs, Sándor Benyhe, Zoltán V. Varga, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani

“…Despite the large arsenal of analgesic medications, neuropathic pain (NP) management is not solved yet. …”
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New Insights into the Opioid Analgesic Profile of <i>cis</i>-(−)-<i>N</i>-Normetazocine-derived Ligands by Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci

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Shedding Light on the Pharmacological Interactions between μ-Opioid Analgesics and Angiotensin Receptor Modulators: A New Option for Treating Chronic Pain by Kornél Király, Dávid Á. Karádi, Ferenc Zádor, Amir Mohammadzadeh, Anna Rita Galambos, Mihály Balogh, Pál Riba, Tamás Tábi, Zoltán S. Zádori, Éva Szökő, Susanna Fürst, Mahmoud Al-Khrasani

Subjects: “…µ-opioid analgesics…”
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On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance by Susanna Fürst, Zoltán S. Zádori, Ferenc Zádor, Kornél Király, Mihály Balogh, Szilvia B. László, Barbara Hutka, Amir Mohammadzadeh, Chiara Calabrese, Anna Rita Galambos, Pál Riba, Patrizia Romualdi, Sándor Benyhe, Júlia Timár, Helmut Schmidhammer, Mariana Spetea, Mahmoud Al-Khrasani

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Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain by Helmut Schmidhammer, Mahmoud Al-Khrasani, Susanna Fürst, Mariana Spetea

“…Opioids are considered the most effective analgesics for the treatment of moderate to severe acute and chronic pain. …”
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Pregabalin–Tolperisone Combination to Treat Neuropathic Pain: Improved Analgesia and Reduced Side Effects in Rats by Nariman Essmat, Anna Rita Galambos, Péter P. Lakatos, Dávid Árpád Karádi, Amir Mohammadzadeh, Sarah Kadhim Abbood, Orsolya Geda, Rudolf Laufer, Kornél Király, Pál Riba, Zoltán S. Zádori, Éva Szökő, Tamás Tábi, Mahmoud Al-Khrasani

“…The dual blockade effect of the combination might explain its advantageous acute analgesic effect in the present work.…”
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Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats by Mihály Balogh, Ferenc Zádor, Zoltán S. Zádori, Mohammed Shaqura, Kornél Király, Amir Mohammadzadeh, Bence Varga, Bernadette Lázár, Shaaban A. Mousa, Sándor Hosztafi, Pál Riba, Sándor Benyhe, Klára Gyires, Michael Schäfer, Susanna Fürst, Mahmoud Al-Khrasani

“…In conclusion, the reduction in the analgesic action of opioids in DNP might be a consequence of MOR reduction, particularly in the spinal cord. …”
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Recent Molecular Insights into Agonist-specific Binding to the Mu-Opioid Receptor by Ferenc Zádor, Kornél Király, Nariman Essmat, Mahmoud Al-Khrasani

“…Opioid agonists produce their analgesic effects primarily by acting at the µ-opioid receptor (µOR). µOR agonists with different efficacies exert diverse molecular changes in the µOR which dictate the faith of the receptor’s signaling pathway and possibly it’s the degree of desensitization. …”
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Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis by Nariman Essmat, Dávid Árpád Karádi, Ferenc Zádor, Kornél Király, Susanna Fürst, Mahmoud Al-Khrasani

“…Opioid receptor agonists, particularly those that activate µ-opioid receptors (MORs), are essential analgesic agents for acute or chronic mild to severe pain treatment. …”
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The Acute Antiallodynic Effect of Tolperisone in Rat Neuropathic Pain and Evaluation of Its Mechanism of Action by Péter P. Lakatos, Dávid Árpád Karádi, Anna Rita Galambos, Nariman Essmat, Kornél Király, Rudolf Laufer, Orsolya Geda, Zoltán S. Zádori, Tamás Tábi, Mahmoud Al-Khrasani, Éva Szökő

“…These results lay the foundation of the avenue for repurposing tolperisone as an analgesic drug to relieve neuropathic pain.…”
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Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model by Amir Mohammadzadeh, Péter P. Lakatos, Mihály Balogh, Ferenc Zádor, Dávid Árpád Karádi, Zoltán S. Zádori, Kornél Király, Anna Rita Galambos, Szilvia Barsi, Pál Riba, Sándor Benyhe, László Köles, Tamás Tábi, Éva Szökő, Laszlo G. Harsing, Mahmoud Al-Khrasani

“…Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. …”
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