Statins and vein graft failure in coronary bypass surgery by Margaritis, M, Channon, K, Antoniades, C

Statins and vein graft failure in coronary bypass surgery. by Margaritis, M, Channon, K, Antoniades, C

NADPH oxidase activity in internal mammary arteries predicts mortality in patients undergoing coronary bypass surgery by Akoumianakis, I, Antonopoulos, AS, Herdman, L, Margaritis, M, Oikonomou, EK, Krasopoulos, G, Petrou, M, Sayeed, R, Channon, KM, Antoniades, C

Adiponectin As A Link Between Type 2 Diabetes Mellitus And Vascular NADPH-Oxidase Activity In The Human Arterial Wall: The Regulatory Role Of Perivascular Adipose Tissue. by Antonopoulos, A, Margaritis, M, Coutinho, P, Shirodaria, C, Psarros, C, Herdman, L, Sanna, F, De Silva, R, Petrou, M, Sayeed, R, Krasopoulos, G, Lee, R, Digby, J, Reilly, S, Bakogiannis, C, Tousoulis, D, Kessler, B, Casadei, B, Channon, K, Antoniades, C

“…Segments of internal mammary arteries (IMA) with their perivascular adipose tissue (PVAT) and thoracic adipose tissue (Th-AT) were obtained from 386 patients undergoing coronary bypass surgery (127 with type 2 diabetes). Type 2 diabetes was strongly correlated with hypoadiponectinemia and increased vascular NADPH-oxidase-derived O2∙(-). …”

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition by Akoumianakis, I, Badi, I, Douglas, G, Chuaiphichai, S, Herdman, L, Akawi, N, Margaritis, M, Antonopoulos, A, Oikonomou, EK, Psarros, C, Galiatsatos, N, Tousoulis, D, Kardos, A, Sayeed, R, Krasopoulos, G, Petrou, M, Schwahn, U, Wohlfart, P, Tennagels, N, Channon, K, Antoniades, C

“…We studied 580 patients with coronary atherosclerosis undergoing coronary artery bypass surgery (CABG), finding that high endogenous insulin was associated with reduced nitric oxide (NO) bioavailability ex vivo in vessels obtained during surgery. …”

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. by Cunnington, C, Van Assche, T, Shirodaria, C, Kylintireas, I, Lindsay, A, Lee, J, Antoniades, C, Margaritis, M, Lee, R, Cerrato, R, Crabtree, M, Francis, J, Sayeed, R, Ratnatunga, C, Pillai, R, Choudhury, R, Neubauer, S, Channon, K

“…METHODS AND RESULTS: Forty-nine patients with coronary artery disease were randomized to receive low-dose (400 mg/d) or high-dose (700 mg/d) BH4 or placebo for 2 to 6 weeks before coronary artery bypass surgery. Vascular function was quantified by magnetic resonance imaging before and after treatment, along with plasma BH4 levels. …”

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease by Cunnington, C, Van Assche, T, Shirodaria, C, Kylintireas, I, Lindsay, A, Lee, J, Antoniades, C, Margaritis, M, Lee, R, Cerrato, R, Crabtree, M, Francis, J, Sayeed, R, Ratnatunga, C, Pillai, R, Choudhury, R, Neubauer, S, Channon, K

“…METHODS AND RESULTS-: Forty-nine patients with coronary artery disease were randomized to receive low-dose (400 mg/d) or high-dose (700 mg/d) BH4 or placebo for 2 to 6 weeks before coronary artery bypass surgery. Vascular function was quantified by magnetic resonance imaging before and after treatment, along with plasma BH4 levels. …”

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis. by Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K

“…In Study 4, vessel segments from 19 patients undergoing coronary bypass surgery were incubated with or without cytokines (interleukin-6/tumor necrosis factor-α/lipopolysaccharide) for 24 hours. …”

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis by Antoniades, C, Cunnington, C, Antonopoulos, A, Neville, M, Margaritis, M, Demosthenous, M, Bendall, J, Hale, A, Cerrato, R, Tousoulis, D, Bakogiannis, C, Marinou, K, Toutouza, M, Vlachopoulos, C, Leeson, P, Stefanadis, C, Karpe, F, Channon, K

“…In Study 4, vessel segments from 19 patients undergoing coronary bypass surgery were incubated with or without cytokines (interleukin-6/tumor necrosis factor-α/lipopolysaccharide) for 24 hours. …”