T064: Doxorubicin exposure and breast cancer risk in adolescent and adult Hodgkin lymphoma survivors by Suzanne I.M. Neppelenbroek, Yvonne M.G. Geurts, Berthe M. P. Aleman, Cécile P.M. Janus, Pieternella J. Lugtenburg, Saskia E. Rademaker, Roel J. De Weijer, Maaike G.A. Schippers, Bastiaan D.P. Ta, Wouter J. Plattel, Josée. M. Zijlstra, Richard W.M. Van Der Maazen, Marten R. Nijziel, Francisca Ong, Erik C. Schimmel, Eduardus F.M. Posthuma, Marie José Kersten, Lara H. Böhmer, Karin Muller, Harry R. Koene, Liane C.J. Te Boome, Yavuz M. Bilgin, Eva De Jongh, Flora E. Van Leeuwen, Michael Schaapveld

Get full text

Conditional relative survival among patients with follicular lymphoma: a population-based study in the Netherlands by Manette A. W. Dinnessen, Otto Visser, Sanne H. Tonino, Eduardus F. M. Posthuma, Nicole M. A. Blijlevens, Marie José Kersten, Pieternella J. Lugtenburg, Avinash G. Dinmohamed

Get full text

Mapping hematologists' HIV testing behavior among lymphoma patients-A mixed-methods study. by Saskia Bogers, Hanne Zimmermann, Amie Ndong, Udi Davidovich, Marie José Kersten, Peter Reiss, Maarten Schim van der Loeff, Suzanne Geerlings, HIV Transmission Elimination AMsterdam (H-TEAM) Consortium

“…<h4>Background</h4>HIV testing among patients with malignant lymphoma (PWML) is variably implemented. We evaluated HIV testing among PWML, and mapped factors influencing hematologists' testing behavior.…”
Get full text

Genetic and Microenvironment Features Do Not Distinguish Follicular Lymphoma Patients Requiring Immediate or Deferred Treatment by Wendy B. C. Stevens, G. Tjitske Los-de Vries, Carole Langois-Jacques, Andrew J. Clear, Phylicia Stathi, Birgitta Sander, Andreas Rosenwald, Maria Calaminici, Eva Hoster, Wolfgang Hiddemann, Philippe Gaulard, Gilles Salles, Wolfram Klapper, Luc Xerri, Catherine Burton, Reuben M. Tooze, Alexandra G. Smith, Christian Buske, David W. Scott, Yasodha Natkunam, Ranjana Advani, Laurie H. Sehn, John Raemaekers, John Gribben, Sandra Lockmer, Eva Kimby, Marie José Kersten, Delphine Maucort-Boulch, Bauke Ylstra, Erik van Dijk, Daphne de Jong

Get full text

The impact of prior malignancies on the development of second malignancies and survival in follicular lymphoma: A population‐based study by Manette A.W. Dinnessen, Otto Visser, Sanne H. Tonino, Marjolein W.M. van derPoel, Nicole M.A. Blijlevens, Marie José Kersten, Pieternella J. Lugtenburg, Avinash G. Dinmohamed

Subjects: “…follicular lymphoma…”
Get full text

Light Therapy for Cancer-Related Fatigue in (Non-)Hodgkin Lymphoma Survivors: Results of a Randomized Controlled Trial by Daniëlle E. J. Starreveld, Laurien A. Daniels, Jacobien M. Kieffer, Heiddis B. Valdimarsdottir, Jessie de Geus, Mirthe Lanfermeijer, Eus J. W. van Someren, G. Esther A. Habers, Jos A. Bosch, Cécile P. M. Janus, Dick Johan van Spronsen, Roel J. de Weijer, Erik W. A. Marijt, Eva de Jongh, Josée M. Zijlstra, Lara H. Böhmer, Margreet Houmes, Marie José Kersten, Catharina M. Korse, Huub H. van Rossum, William H. Redd, Susan K Lutgendorf, Sonia Ancoli-Israel, Flora E. van Leeuwen, Eveline M. A. Bleiker

“…Purpose: To evaluate the short- and long-term effects of light therapy on fatigue (primary outcome) and sleep quality, depression, anxiety, quality of life, and circadian rhythms (secondary outcomes) in survivors of (non-)Hodgkin lymphoma presenting with chronic cancer-related fatigue. …”
Get full text

Treatment and outcomes for patients with relapsed or refractory diffuse large B-cell lymphoma: a contemporary, nationwide, population-based study in the Netherlands by Elise R. A. Pennings, Müjde Durmaz, Otto Visser, Eduardus F. M. Posthuma, Djamila E. Issa, Martine E. D. Chamuleau, Pieternella J. Lugtenburg, Marie José Kersten, Avinash G. Dinmohamed

Get full text

MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas by Marthe Minderman, Hildo C. Lantermans, Leonie J. Grüneberg, Saskia A. G. M. Cillessen, Richard J. Bende, Carel J. M. van Noesel, Marie José Kersten, Steven T. Pals, Marcel Spaargaren

“…Here, we show that low expression of CYLD is associated with inferior prognosis of diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) patients, and that chronic BCR signaling propagates MALT1-mediated cleavage and, consequently, inactivation and rapid proteasomal degradation of CYLD. …”
Get full text

The oncogenic human B-cell lymphoma MYD88 L265P mutation genocopies activation by phosphorylation at the Toll/interleukin-1 receptor (TIR) domain by Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals

“…A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a significant subset of diffuse large B-cell lymphomas. MYD88-L265P strongly promotes NF-κB pathway activation, JAK-STAT signaling and lymphoma cell survival. …”
Get full text

P1128: EVALUATION OF STANDARD OF CARE IN SECOND-LINE FOR PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA IN THE PRE-CAR-T ERA: A DUTCH POPULATION-BASED STUDY by Elise R.A. Pennings, Müjde Durmaz, Otto Visser, Eduardus F.M. Posthuma, Djamila E. Issa, Martine E.D. Chamuleau, Anne M. Spanjaart, Tom van Meerten, Pim G.N.J. Mutsaers, Margot Jak, Suzanne van Dorp, Joost S.P. Vermaat, Marjolein W.M. van der Poel, Maria T. Kuipers, Frederick W. Thielen, Carin A. Uyl-de Groot, Pieternella J. Lugtenburg, Marie José Kersten, Avinash G. Dinmohamed

Get full text

P107: Effect of Brentuximab Vedotin Addition to Chemotherapy and Prognostic Factors in Patients with Relapsed/Refractory Hodgkin Lymphoma: a Large Multi-Trial Analysis Based on Individual Patient Data by Julia Driessen, Fer De Wit, Alex F. Herrera, Pier Luigi Zinzani, Ann S. Lacasce, Peter D. Cole, Craig H. Moskowitz, Ramón. García Sanz, Michael Fuchs, Horst Müller, Peter Borchmann, Armando Santoro, Heiko Schöder, Josée. M. Zijlstra, Barbara A. Hutten, Alison J. Moskowitz, Marie José Kersten

Get full text

Biological and Clinical Implications of Gene-Expression Profiling in Diffuse Large B-Cell Lymphoma: A Proposal for a Targeted BLYM-777 Consortium Panel as Part of a Multilayered Analytical Approach by Fleur A. de Groot, Ruben A. L. de Groen, Anke van den Berg, Patty M. Jansen, King H. Lam, Pim G. N. J. Mutsaers, Carel J. M. van Noesel, Martine E. D. Chamuleau, Wendy B. C. Stevens, Jessica R. Plaça, Rogier Mous, Marie José Kersten, Marjolein M. W. van der Poel, Thomas Tousseyn, F. J. Sherida H. Woei-a-Jin, Arjan Diepstra, Marcel Nijland, Joost S. P. Vermaat

“…Gene-expression profiling (GEP) is used to study the molecular biology of lymphomas. Here, advancing insights from GEP studies in diffuse large B-cell lymphoma (DLBCL) lymphomagenesis are discussed. …”
Get full text

HOVON110/ReBeL Study: Results of the Phase I Part of a Randomized Phase I/II Study of Lenalidomide, Rituximab With or Without Bendamustine in Patients With Relapsed/Refractory Follicular Lymphoma by Wendy B.C. Stevens, Katerina Bakunina, Marloes Cuijpers, Martine Chamuleau, Aart Beeker, Rob Fijnheer, Holger Hebart, Hein P.J. Visser, Jeanette K. Doorduijn, Kim Linton, Martin Dreyling, Daphne de Jong, Marie José Kersten

Get full text

The Dutch CAR-T Tumorboard Experience: Population-Based Real-World Data on Patients with Relapsed or Refractory Large B-Cell Lymphoma Referred for CD19-Directed CAR T-Cell Therapy in The Netherlands by Anne M. Spanjaart, Elise R. A. Pennings, Pim G. N. J. Mutsaers, Suzanne van Dorp, Margot Jak, Jaap A. van Doesum, Janneke W. de Boer, Anne G. H. Niezink, Milan Kos, Joost S. P. Vermaat, Aniko Sijs-Szabo, Marjolein W. M. van der Poel, Inger S. Nijhof, Maria T. Kuipers, Martine E. D. Chamuleau, Pieternella J. Lugtenburg, Jeanette K. Doorduijn, Yasmina I. M. Serroukh, Monique C. Minnema, Tom van Meerten, Marie José Kersten

“…The real-world results of chimeric antigen receptor T-cell (CAR-T) therapy for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL) substantially differ across countries. …”
Get full text

P1139: COMPARISON OF 6XR-CHOP21 VERSUS 6XR-CHOP+2R FOR ADVANCED-STAGE DIFFUSE LARGE B-CELL LYMPHOMA: A PROPENSITY SCORE WEIGHTED POPULATION-BASED ANALYSIS by Carolien Maas, David van Klaveren, Mujde Durmaz, Otto Visser, Djamila Issa, Eduardus F.M. Posthuma, Josée Zijlstra, Martine Chamuleau, Pieternella Lugtenburg, Marie José Kersten, Avinash Dinmohamed

Get full text

EHA Endorsement of ESMO Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up for Waldenström’s Macroglobulinemia by Philipp B. Staber, Marie José Kersten, on behalf of the EHA Guidelines Committee

Get full text

Health Economic Aspects of Chimeric Antigen Receptor T-cell Therapies for Hematological Cancers: Present and Future by Renaud Heine, Frederick W. Thielen, Marc Koopmanschap, Marie José Kersten, Hermann Einsele, Ulrich Jaeger, Pieter Sonneveld, Jorge Sierra, Carin Smand, Carin A. Uyl-de Groot

“…We estimated market entry of CAR T-cell therapies for chronic mantle cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, multiple myeloma, and acute myeloid leukemia in 2021, 2022, 2022, 2022, and 2025, respectively. …”
Get full text

Olecranon bursitis caused by Scedosporium apiospermum in a patient treated with CAR-T cells by Willem J.J. Falkenburg, Marit Jalink, Marie José Kersten, Jochem B. Buil, Karin van Dijk

“…We report a case of Scedosporium apiospermum infection causing bursitis of the elbow in a lymphoma patient after treatment with CAR-T cells. …”
Get full text

Chimeric Antigen Receptor-T Cell Therapy by Jochen Buechner, Marie José Kersten, Miriam Fuchs, Florence Salmon, Ulrich Jäger

“…Tisagenlecleucel has shown robust in vivo expansion and long-term persistence, clinically meaningful durable response and remission rates, and overall survival benefit in pediatric and young adult patients with relapsed/refractory B-ALL and in relapsed/refractory diffuse large B-cell lymphoma. Common adverse events (AEs) include cytokine release syndrome, which may require hospitalization and admission to an intensive care unit, neurological toxicities, and B-cell aplasia. …”
Get full text

Dutch Physician’s Perspectives on Diagnosis and Treatment of Waldenström’s Macroglobulinemia Before and After the Implementation of a National Guideline by Karima Amaador, Marie José Kersten, Monique C. Minnema, Josephine M. I. Vos

“…Waldenström’s macroglobulinemia (WM), a rare low-grade B-cell non-Hodgkin lymphoma (NHL), has a distinct clinical presentation and different treatment-related side effects compared with other NHL. …”
Get full text