Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. by Kühn, T, Kaaks, R, Becker, S, Eomois, P, Clavel-Chapelon, F, Kvaskoff, M, Dossus, L, Tjønneland, A, Olsen, A, Overvad, K, Chang-Claude, J, Lukanova, A, Buijsse, B, Boeing, H, Trichopoulou, A, Lagiou, P, Bamia, C, Masala, G, Krogh, V, Sacerdote, C, Tumino, R, Mattiello, A, Buckland, G, Sánchez, M, Menéndez, V

Mitochondrial DNA copy number and future risk of B-cell lymphoma in a nested case-control study in the prospective EPIC cohort. by Hosnijeh, F, Lan, Q, Rothman, N, San Liu, C, Cheng, W, Nieters, A, Guldberg, P, Tjønneland, A, Campa, D, Martino, A, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Krogh, V, Tumino, R, Panico, S, Masala, G, Weiderpass, E, Huerta Castaño, J, Ardanaz, E, Sala, N, Dorronsoro, M, Quirós, JR, Sánchez, M

“…However, current evidence is limited and based on a relatively small number of cases. Using a nested case-control study, we extended these findings with a focus on subtype-specific analyses. …”

Prediagnostic serum vitamin D levels and the risk of Crohn’s disease and ulcerative colitis in European populations: a nested case-control study by Opstelten, J, Chan, S, Hart, A, Van Schaik, F, Siersema, P, Lentjes, E, Khaw, K, Luben, R, Key, T, Boeing, H, Bergmann, M, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Peeters, P, Verschuren, W, Witteman, B, Oldenburg, B

Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition by Cheng, TS, Noor, U, Watts, E, Pollak, M, Wang, Y, McKay, J, Atkins, J, Masala, G, Sánchez, M, Agudo, A, Castilla, J, Aune, D, Colorado-Yohar, SM, Manfredi, L, Gunter, MJ, Pala, V, Josefsson, A, Key, TJ, Smith-Byrne, K, Travis, RC

“…Methods: We analyzed data from 767 prostate cancer cases and 767 matched controls nested within the European Prospective Investigation into Cancer and Nutrition cohort, with an average of 14-years (interquartile range = 2.9) follow-up. …”

A nested case-control study of metabolically defined body size phenotypes and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Murphy, N, Cross, A, Abubakar, M, Jenab, M, Aleksandrova, K, Boutron-Ruault, M, Dossus, L, Racine, A, Kühn, T, Katzke, V, Tjønneland, A, Petersen, K, Overvad, K, Quirós, JR, Jakszyn, P, Molina-Montes, E, Dorronsoro, M, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, H, Siersema, P, Peeters, P, Ohlsson, B, Ericson, U, Palmqvist, R, Nyström, H, Weiderpass, E, Skeie, G, Freisling, H, Kong, S, Tsilidis, K, Muller, D, Riboli, E, Gunter, M

“…Whether similarly variable relationships exist for metabolically defined body size phenotypes and colorectal cancer risk is unknown.The association of metabolically defined body size phenotypes with colorectal cancer was investigated in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. …”

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) by Harewood, R, Rothwell, JA, Bešević, J, Viallon, V, Achaintre, D, Gicquiau, A, Rinaldi, S, Wedekind, R, Prehn, C, Adamski, J, Schmidt, JA, Jacobs, I, Tjønneland, A, Olsen, A, Severi, G, Kaaks, R, Katzke, V, Schulze, MB, Prada, M, Masala, G, Agnoli, C, Panico, S, Sacerdote, C, Jakszyn, PG, Sánchez, M-J, Castilla, J, Chirlaque, M-D, Atxega, AA, van Guelpen, B, Heath, AK, Papier, K, Tong, TYN, Summers, SA, Playdon, M, Cross, AJ, Keski-Rahkonen, P, Chajès, V, Murphy, N, Gunter, MJ

“…</p> <p><strong>Methods:</strong>&nbsp;In a case&ndash;control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. …”

Soluble receptor for advanced glycation end-products (sRAGE) and colorectal cancer risk: a case–control study nested within a European prospective cohort by Aglago, EK, Rinaldi, S, Freisling, H, Jiao, L, Hughes, DJ, Fedirko, V, Schalkwijk, CG, Weiderpass, E, Dahm, CC, Overvad, K, Eriksen, AK, Kyrø, C, Boutron-Ruault, M-C, Rothwell, JA, Severi, G, Katzke, V, Kühn, T, Schulze, MB, Aleksandrova, K, Masala, G, Krogh, V, Panico, S, Tumino, R, Naccarati, A, Bueno-de-Mesquita, B, van Gils, CH, Sandanger, TM, Gram, IT, Skeie, G, Quirós, JR, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Ardanaz, E, Johansson, I, Harlid, S, Perez-Cornago, A, Mayén, A-L, Cordova, R, Gunter, MJ, Vineis, P, Cross, AJ, Riboli, E, Jenab, M

“…</p> <p><strong>Methods:</strong> To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). …”

Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). by Nagel, G, Linseisen, J, Boshuizen, H, Pera, G, Del Giudice, G, Westert, G, Bueno-de-Mesquita, H, Allen, N, Key, T, Numans, M, Peeters, P, Sieri, S, Siman, H, Berglund, G, Hallmans, G, Stenling, R, Martinez, C, Arriola, L, Barricarte, A, Chirlaque, MD, Quiros, JR, Vineis, P, Masala, G, Palli, D, Panico, S

“…We examined the effect of socioeconomic position on cancer risk by means of educational data and a computed Relative Index of Inequality (RII). In a nested case-control study, adjustment for Helicobacter pylori (H. pylori) infection was performed. …”

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. by Ose, J, Fortner, RT, Schock, H, Peeters, P, Onland-Moret, N, Bueno-de-Mesquita, H, Weiderpass, E, Gram, I, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E

“…METHODS: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). …”

Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) coh... by Duell, E, Travier, N, Lujan-Barroso, L, Dossus, L, Boutron-Ruault, M, Clavel-Chapelon, F, Tumino, R, Masala, G, Krogh, V, Panico, S, Ricceri, F, Redondo, M, Dorronsoro, M, Molina-Montes, E, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Allen, N, Travis, R, Siersema, P, Peeters, P, Trichopoulou, A, Fragogeorgi, E, Oikonomou, E

“…Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). …”

Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition by Perez-Cornago, A, Appleby, P, Tipper, S, Key, T, Allen, N, Nieters, A, Vermeulen, R, Roulland, S, Casabonne, D, Kaaks, R, Fortner, R, Boeing, H, Trichopoulou, A, La Vecchia, C, Klinaki, E, Hansen, L, Tjønneland, A, Bonnet, F, Fagherazzi, G, Boutron-Ruault, M, Pala, V, Masala, G, Sacerdote, C, Peeters, P, Bueno-de-Mesquita, H, Weiderpass, E, Dorronsoro, M, Quirós, J, Barricarte, A, Gavrila, D, Agudo, A, Borgquist, S, Rosendahl, A, Melin, B, Wareham, N, Khaw, K, Gunter, M, Riboli, E, Vineis, P, Travis, R

“…IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1072 cases of lymphoid malignancies and 1072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. …”

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk by Campa, D, Hüsing, A, McKay, J, Sinilnikova, O, Vogel, U, Tjønneland, A, Overvad, K, Stegger, J, Clavel-Chapelon, F, Chabbert-Buffet, N, Fagherazzi, G, Trichopoulou, A, Zylis, D, Oustoglou, E, Rohrmann, S, Teucher, B, Fisher, E, Boeing, H, Masala, G, Krogh, V, Sacerdote, C, Panico, S, Tumino, R, Onland-Moret, N, Gils, V, Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Quirós, JR, Ardanaz, E, Amiano, P, Molina-Montes, E, Hallmans, G, Lenner, P, Travis, R, Key, T, Wareham, N, Khaw, K, Rinaldi, S, Slimani, N, Chajes, V, Siddiq, A, Riboli, E, Kaaks, R, Canzian, F

“…<br/><br/> <b>Methods:</b> we tested in a large-scale association study (3,973 women, including 1,269 invasive BC cases and 2,194 controls), nested within the EPIC cohort, the involvement of rs7566605 as predictor of BMI and BC risk.…”

Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: A cross-sectional study within the EPIC cohort by Rinaldi, S, Kaaks, R, Friedenreich, C, Key, T, Travis, R, Biessy, C, Slimani, N, Overvad, K, Østergaard, J, Tjønneland, A, Olsen, A, Mesrine, S, Fournier, A, Dossus, L, Lukanova, A, Johnson, T, Boeing, H, Vigl, M, Trichopoulou, A, Benetou, V, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F

“…Methods: A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women included as controls in case-control studies on endogenous hormones (steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth factors) levels, and cancer risk nested within European Prospective Investigation into Cancer and Nutrition cohort was performed. …”

Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium by Ose, J, Poole, E, Schock, H, Lehtinen, M, Arslan, A, Zeleniuch-Jacquotte, A, Visvanathan, K, Helzlsouer, K, Buring, J, Lee, I, Tjønneland, A, Dossus, L, Trichopoulou, A, Masala, G, Onland-Moret, N, Weiderpass, E, Duell, E, Idahl, A, Travis, R, Rinaldi, S, Merritt, M, Trabert, B, Wentzensen, N, Tworoger, S, Kaaks, R, Fortner, R

“…We conducted a pooled analysis of 7 nested case-control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens (testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)), sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e. histology, grade, and stage). …”

Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort by Kyro, C, Olsen, A, Bueno-De-Mesquita, H, Skeie, G, Loft, S, Åman, P, Leenders, M, Dik, V, Siersema, P, Pischon, T, Christensen, J, Overvad, K, Boutron-Ruault, M, Fagherazzi, G, Cottet, V, Kühn, T, Chang-Claude, J, Boeing, H, Trichopoulou, A, Naska, A, Oikonomidou, D, Masala, G, Pala, V, Tumino, R, Vineis, P

“…In the present study, we analysed the plasma concentrations of five AR homologues in 2845 participants from ten European countries from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition. …”

Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. by Kyrø, C, Olsen, A, Bueno-de-Mesquita, H, Skeie, G, Loft, S, Åman, P, Leenders, M, Dik, V, Siersema, P, Pischon, T, Christensen, J, Overvad, K, Boutron-Ruault, M, Fagherazzi, G, Cottet, V, Kühn, T, Chang-Claude, J, Boeing, H, Trichopoulou, A, Naska, A, Oikonomidou, D, Masala, G, Pala, V, Tumino, R, Vineis, P

“…In the present study, we analysed the plasma concentrations of five AR homologues in 2845 participants from ten European countries from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition. …”

Endometrial cancer risk prediction including serum-based biomarkers: Results from the EPIC cohort by Fortner, R, Hüsing, A, Kühn, T, Konar, M, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, M, Severi, G, Fournier, A, Boeing, H, Trichopoulou, A, Benetou, V, Orfanos, P, Masala, G, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, H, Peeters, P, Weiderpass, E, Gram, I, Gavrilyuk, O, Quirós, J, Huerta, J, Ardanaz, E, Larrañaga, N, Lujan-Barroso, L, Sánchez-Cantalejo, E, Butt, S, Borgquist, S, Idahl, A, Lundin, E, Khaw, K, Allen, N, Rinaldi, S, Dossus, L, Gunter, M, Merritt, M, Tzoulaki, I, Riboli, E, Kaaks, R

“…Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement in discrimination gained by adding serum biomarker concentrations to risk estimates derived from an existing risk prediction model based on epidemiologic factors. …”

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition. by Ose, J, Fortner, RT, Rinaldi, S, Schock, H, Overvad, K, Tjonneland, A, Hansen, L, Dossus, L, Fournier, A, Baglietto, L, Romieu, I, Kuhn, E, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Masala, G, Sieri, S, Tumino, R, Sacerdote, C, Mattiello, A, Ramon Quiros, J, Obón-Santacana, M, Larrañaga, N

“…Epithelial invasive ovarian cancer (EOC) is a heterogeneous disease and there are no prospective data on endogenous androgens and EOC risk by tumor characteristics (histology, grade, stage) or the dualistic model of ovarian carcinogenesis (i.e. type I vs. type II, leading to less or more aggressive tumors). We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort evaluating androgens and SHBG and invasive EOC risk by tumor characteristics. …”

Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort. by Rinaldi, S, Kaaks, R, Friedenreich, C, Key, T, Travis, R, Biessy, C, Slimani, N, Overvad, K, Østergaard, J, Tjønneland, A, Olsen, A, Mesrine, S, Fournier, A, Dossus, L, Lukanova, A, Johnson, T, Boeing, H, Vigl, M, Trichopoulou, A, Benetou, V, Trichopoulos, D, Masala, G, Krogh, V, Tumino, R, Ricceri, F

“…METHODS: A cross-sectional analysis of 798 pre- and 1,360 post-menopausal women included as controls in case-control studies on endogenous hormones (steroids, progesterone, sex-hormone-binding globulin (SHBG), and growth factors) levels, and cancer risk nested within European Prospective Investigation into Cancer and Nutrition cohort was performed. …”