Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites by Kedaigle, Amanda J, Fraenkel, Ernest

“…Altered cellular metabolism is believed to be an important contributor to pathogenesis of the neurodegenerative disorder Huntington’s disease (HD). …”
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Localized metabolomic gradients in patient-derived xenograft models of glioblastoma by Randall, Elizabeth C, Lopez, Begoña GC, Peng, Sen, Regan, Michael S, Abdelmoula, Walid M, Basu, Sankha S, Santagata, Sandro, Yoon, Haejin, Haigis, Marcia C, Agar, Jeffrey N, Tran, Nhan L, Elmquist, William F, White, Forest M., Sarkaria, Jann N, Agar, Nathalie YR

“…Glioblastoma (GBM) is increasingly recognized as a disease involving dysfunctional cellular metabolism. GBMs are known to be complex heterogeneous systems containing multiple distinct cell populations and are supported by an aberrant network of blood vessels. …”
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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis by Banko, Max R., Allen, Jasmina J., Schaffer, Bethany E., Wilker, Erik W., Tsou, Peiling, White, Jamie L., Villen, Judit, Wang, Beatrice, Kim, Sara R., Sakamoto, Kei, Gygi, Steven P., Cantley, Lewis C., Yaffe, Michael B., Shokat, Kevan M., Brunet, Anne

“…Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use a chemical genetics screen to identify direct substrates of AMPK in human cells. …”
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Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition by Freinkman, Elizaveta, Comb, William C., Cantor, Jason R., Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward

“…It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. …”
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Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit by Gupta, Apoorv, Brockman Reizman, Irene M., Reisch, Christopher R., Prather, Kristala L

“…Metabolic engineering of microorganisms to produce desirable products on an industrial scale can result in unbalanced cellular metabolic networks that reduce productivity and yield. …”
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Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling by Mina, Sara G., Alaybeyoglu, Begum, Murphy, William L., Thomson, James A., Stokes, Cynthia L., Cirit, Murat

“…This suggests that early cellular metabolic dysfunction leads to later DJ-1 leakage and cell death, and that early measurement of this subset of metabolites could predict the later occurrence of cell death. …”
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