MicrobesOnline: an integrated portal for comparative and functional genomics by Dehal, Paramvir S., Joachimiak, Marcin P., Price, Morgan N., Bates, John T., Baumohl, Jason K., Chivian, Dylan, Friedland, Greg D., Huang, Katherine H., Keller, Keith, Novichkov, Pavel S., Dubchak, Inna L., Alm, Eric J., Arkin, Adam P.

“…MicrobesOnline also includes fast phylogenetic profile searches, comparative views of metabolic pathways, operon predictions, a workbench for sequence analysis and integration with RegTransBase and other microbial genome resources. …”
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Fabrication and Characterization of an Integrated Microsystem for Protein Preconcentration and Sensing by Dextras, Philip, Payer, Kristofor Robert, Burg, Thomas P., Shen, Wenjiang, Wang, Ying-Chih, Han, Jongyoon, Manalis, Scott R.

“…The initial testing of this prototype device has demonstrated that the integrated SMR can accurately measure the concentration of a bovine serum albumin solution, that was preconcentrated using the integrated NC. …”
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Integrated network analyses for functional genomic studies in cancer by Fraenkel, Ernest, Wilson, Jennifer Lynn, Hemann, Michael, Lauffenburger, Douglas A

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Profiling human antibody responses by integrated single-cell analysis by Ogunniyi, Adebola Oluwakayode, Politano, Timothy J., Varadarajan, Navin, Landais, Elise, Poignard, Pascal, Walker, Bruce D., Kwon, Douglas S., Love, J. Christopher, Thomas, Brittany Anne

“…Here we present an integrated analytical platform, using arrays of subnanoliter wells (nanowells), for constructing detailed profiles for human B cells comprising the immunophenotypes of these cells, the distribution of isotypes of the secreted antibodies, the specificity and relative affinity for defined antigens, and for a subset of cells, the genes encoding the heavy and light chains. …”
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Multiscale mechanobiology: computational models for integrating molecules to multicellular systems by Kim, Taeyoon, Zaman, Muhammad H., Mak, Michael, Kamm, Roger Dale

“…Computational models that accurately predict and are based on experimental data enable a means to integrate basic principles and explore fine details of mechanosensing and mechanotransduction in and across all levels of biological systems. …”
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Structure of the EGF receptor transactivation circuit integrates with cell context by Joslin, Elizabeth J., Shankaran, Harish, Opresko, Lee K., Bollinger, Nikki, Lauffenburger, Douglas A., Wiley, H. Steven

“…Our results suggest that the transactivation circuit acts as a context-dependent integrator and amplifier of multiple extracellular signals and that signal integration can effectively occur at multiple points in the EGFR pathway.…”
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Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies by Stokes, Cynthia L, Tsamandouras, Nikolaos, Chen, Wen Li, Edington, Collin D, Griffith, Linda G, Cirit, Murat

“…We envision that our integrative approach, which combines multi-cellular tissue models, multi-MPS platforms, and quantitative mechanistic modeling, will have broad applicability in pre-clinical drug development.…”
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Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies by Stokes, Cynthia L, Tsamandouras, Nikolaos, Chen, Wen Li, Edington, Collin D, Griffith, Linda G, Cirit, Murat

“…We envision that our integrative approach, which combines multi-cellular tissue models, multi-MPS platforms, and quantitative mechanistic modeling, will have broad applicability in pre-clinical drug development.…”
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An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum by Nasamu, Armiyaw S, Falla, Alejandra, Pasaje, Charisse Flerida A, Wall, Bridget A, Wagner, Jeffrey C, Ganesan, Suresh M, Goldfless, Stephen J, Niles, Jacquin C

“…We address this bottleneck by devising a DNA assembly framework leveraging the improved reliability with which large AT-rich regions can be efficiently manipulated in linear plasmids. This framework integrates several key functional genetics outcomes via CRISPR/Cas9 and other methods from a common, validated framework. …”
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A multi-landing pad DNA integration platform for mammalian cell engineering by Wroblewska, Liliana, Nelson, Tom, Zhang, Xin, Liu, Yan, Lowe, Alexis, Bandara, Kalpanie, Baijuraj, Swetha, Zhang, Lin, Gaydukov, Leonid A., Teague, Brian Paul, Jagtap, Kalpana P, Mamo, Selamawit W, Tseng, Wen Allen, Das, Jishnu, Summers, Nevin M, Lu, Timothy K, Weiss, Ron

“…Because the integration was targeted to pre-validated loci, recombinant protein expression remained stable for weeks and additional copies of the antibody cassette in the integrated payload resulted in a linear increase in antibody expression. …”
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Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma by Randall, Elizabeth C., Laramy, Janice K., Kim, Minjee, Roos, Alison, Calligaris, David, Regan, Michael S., Gupta, Shiv K., Mladek, Ann C., Carlson, Brett L., Johnson, Aaron J., Lu, Fa-Ke, Xie, X. Sunney, Peng, Sen, Abdelmoula, Walid M., Jackson, Pamela R., Kolluri, Aarti, Kellersberger, Katherine A., Agar, Jeffrey N., Swanson, Kristin R., Tran, Nhan L., Elmquist, William F., Sarkaria, Jann N., Agar, Nathalie Y. R., Emdal, Kristina Bennet, Joughin, Brian Alan, Reddy, Raven J., Lauffenburger, Douglas A, White, Forest M.

“…Phosphoproteomics and immunohistochemistry were used to assess protein signaling in response to drug, and integrated with transcriptional response using mRNA sequencing. …”
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Integrated Proteomic and Glycoproteomic Characterization of Human High-Grade Serous Ovarian Carcinoma

“…© 2020 The Authors Hu et al. provide an integrated proteomic and glycoproteomic characterization of high-grade serous ovarian carcinomas and relevant non-tumor tissues, which reveals tumor-specific glycosylation, uncovers different glycosylation associated with three tumor clusters, and identifies glycosylation enzymes correlated with glycosylation alterations.…”
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Integrated data management and validation platform for phosphorylated tandem mass spectrometry data by Lahesmaa-Korpinen, Anna-Maria, Carlson, Scott M., White, Forest M., Hautaniemi, Sampsa

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An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum by Lee, Marcus CS, Fidock, David A, Wagner, Jeffrey Charles, Goldfless, Stephen Jacob, Maddur Ganesan, Suresh, Niles, Jacquin

“…These vectors are also compatible with traditional cloning by restriction and ligation, and contain useful combinations of commonly used features for enhancing plasmid segregation and site-specific integration in P. falciparum. Additionally, application of a 2A-like peptide for the synthesis of multiple proteins from a single expression cassette, and some rules for combinatorially directing proteins to discrete subcellular compartments were established. …”
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Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report by Zeiger, Errol, Gollapudi, Bhaskar, Aardema, Marilyn J., Auerbach, Scott, Boverhof, Darrell, Custer, Laura, Honma, Masamitsu, Ishida, Seiichi, Kasinski, Andrea L., Kim, James H., Manjanatha, Mugimane G., Marlowe, Jennifer, Pfuhler, Stefan, Pogribny, Igor, Slikker, William, Stankowski, Leon F., Tanir, Jennifer Y., Tice, Raymond, van Benthem, Jan, White, Paul, Witt, Kristine L., Thybaud, Véronique, Dedon, Peter C.

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14-3-3 proteins as signaling integration points for cell cycle control and apoptosis by Gardino, Alexandra K., Yaffe, Michael B

“…Recognition of 14-3-3 proteins as signaling integrators that connect protein kinase signaling pathways to resulting cellular phenotypes, and their exquisite control through feedforward and feedback loops, identifies new drug targets for human disease, and highlights the emerging importance of using systems-based approaches to understand signal transduction events at the network biology level.…”
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Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics by Wang, Xin, Cirit, Murat, Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven R

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Integrated metatranscriptomic and metagenomic analyses of stratified microbial assemblages in the North Pacific Subtropical Gyre by Shi, Yanmei, Tyson, Gene W., Eppley, John Marmaduke, DeLong, Edward

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Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia by Tan, Kai S., Choi, Hyungwon, Jiang, Xiaoou, Yin, Lu, Seet, Ju E., Patzel, Volker, Chow, Vincent T. K., Tan, Kai, Seet, Ju, Engelward, Bevin P.

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Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells by Nissim, Lior, Fridkin, Alexandra, Perez-Pinera, Pablo, Lu, Timothy K., Perli, Samuel

“…RNA-based regulation and CRISPR/Cas transcription factors (CRISPR-TFs) have the potential to be integrated for the tunable modulation of gene networks. …”
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