Orthogonal Dietary Niche Enables Reversible Engraftment of a Gut Bacterial Commensal by Kearney, Sean M, Gibbons, Sean Michael, Erdman, Susan E, Alm, Eric J

“…We observe a diet-dependent loss in seaweed responsiveness of B. plebeius in the long term and show the potential for IgA-mediated control of putative invaders by the immune system. These results point to the potential for diet-based intervention as a means to introduce target organisms, but also indicate potential modes for failure of this strategy in the long term.…”
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A Mena Invasion Isoform Potentiates EGF-Induced Carcinoma Cell Invasion and Metastasis by Philippar, Ulrike, Roussos, Evanthia T., Oser, Matthew, Yamaguchi, Hideki, Kim, Hyung-Do, Giampieri, Silvia, Wang, Yarong, Goswami, Sumanta, Wyckoff, Jeffrey B., Sahai, Erik, Condeelis, John S., Gertler, Frank, Lauffenburger, Douglas A

“…The spread of cancer during metastatic disease requires that tumor cells subvert normal regulatory networks governing cell motility to invade surrounding tissues and migrate toward blood and lymphatic vessels. …”
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Extracellular Matrix Heterogeneity Regulates Three-Dimensional Morphologies of Breast Adenocarcinoma Cell Invasion by Shin, Yoojin, Kim, Hyunju, Han, Sewoon, Won, Jihee, Jeong, Hyo Eun, Lee, Eun-Sook, Kim, Jae-Hong, Chung, Seok, Kamm, Roger Dale

“…This successfully demonstrates the metastatic potential of cancer cells and their effective strategies of ECM proteolytic remodeling and morphological change, while interacting with other cells and invading into heterogeneous ECMs.…”
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Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite by Dankwa, Selasi, Lim, Caeul, Bei, Amy K., Jiang, Rays H. Y., Abshire, James Robbins, Patel, Saurabh D., Goldberg, Jonathan M., Moreno, Yovany, Kono, Maya, Niles, Jacquin C., Duraisingh, Manoj T.

“…A human-adapted P. knowlesi line invades human RBCs independently of Neu5Gc, with duplication of the sialic acid-independent invasion ligand, PkDBPα and loss of PkDBPγ. …”
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Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics by Mak, Michael, Spill, Fabian, Kamm, Roger Dale, Zaman, Muhammad

“…In diseases, such as metastatic cancer, they invade across physiological barriers and remodel their local environments through force, matrix degradation, synthesis, and reorganization. …”
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Salivary mucins in host defense and disease prevention by Frenkel, Erica Shapiro, Ribbeck, Katharina

“…Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical components of the gel layer that protect against invading pathogens. Altered mucin production has been implicated in diseases such as ulcerative colitis, asthma, and cystic fibrosis, which highlights the importance of mucins in maintaining homeostasis. …”
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity by Irvine, Darrell

“…PRRs detect unique chemical patterns associated with invading microorganisms, but whether and how the physical properties of PRR ligands influence the development of the immune response remains unknown. …”
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The cellular architecture of the antimicrobial response network in human leprosy granulomas by Ma, Feiyang, Hughes, Travis K, Teles, Rosane MB, Andrade, Priscila R, de Andrade Silva, Bruno J, Plazyo, Olesya, Tsoi, Lam C, Do, Tran, Wadsworth, Marc H, Oulee, Aislyn, Ochoa, Maria Teresa, Sarno, Euzenir N, Iruela-Arispe, M Luisa, Klechevsky, Eynav, Bryson, Bryan, Shalek, Alex K, Bloom, Barry R, Gudjonsson, Johann E, Pellegrini, Matteo, Modlin, Robert L

“…Granulomas are complex cellular structures composed predominantly of macrophages and lymphocytes that function to contain and kill invading pathogens. Here, we investigated the single-cell phenotypes associated with antimicrobial responses in human leprosy granulomas by applying single-cell and spatial sequencing to leprosy biopsy specimens. …”
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Identification of malaria parasite-infected red blood cell surface aptamers by inertial microfluidic SELEX (I-SELEX) by Birch, Christina M., Hou, Han Wei, Han, Jongyoon, Niles, Jacquin

“…Plasmodium falciparum malaria parasites invade and remodel human red blood cells (RBCs) by trafficking parasite-synthesized proteins to the RBC surface. …”
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Elucidation of the Roles of Tumor Integrin  1 in the Extravasation Stage of the Metastasis Cascade by Chen, Michelle B., Lamar, John, Li, Ran, Hynes, Richard O., Kamm, Roger Dale

“…Specifically, adhesion via α3β1 and α6β1 to subendothelial laminin was a critical prerequisite for successful transmigration. β1 was required to invade past the endothelial basement membrane, whereas its attenuation in a syngeneic tumor model resulted in reduced metastatic colonization of the lung, an effect not observed upon depletion of other integrin alpha and beta subunits. …”
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Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network by Keegan, Caroline, Krutzik, Stephan, Schenk, Mirjam, Scumpia, Phillip O., Pang, Yan Ling Joy, Russell, Brandon S, Lim, Kok Seong, Shell, Scarlet, Prestwich, Erin, Su, Dan, Elashoff, David, Hershberg, Robert M., Bloom, Barry R., Belisle, John T., Fortune, Sarah, Dedon, Peter C, Pellegrini, Matteo, Modlin, Robert L., Lu, Jing,Ph.D.Massachusetts Institute of Technology.

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