Principles of synthetic biology: a MOOC for an emerging field by Anderson, Daniel, Jones, Ross D., Weiss, Ron

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Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite by Dankwa, Selasi, Lim, Caeul, Bei, Amy K., Jiang, Rays H. Y., Abshire, James Robbins, Patel, Saurabh D., Goldberg, Jonathan M., Moreno, Yovany, Kono, Maya, Niles, Jacquin C., Duraisingh, Manoj T.

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More than an adaptor molecule: The emerging role of tRNA in cell signaling and disease by Ribas de Pouplana, Lluis, Dedon, Peter C.

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Cell–Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research by Holle, Andrew W., Young, Jennifer L., Discher, Dennis, Janmey, Paul, Spatz, Joachim P., Saif, Taher, Van Vliet, Krystyn J, Kamm, Roger Dale

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Emergent heterogeneity in putative mesenchymal stem cell colonies: Single-cell time lapsed analysis by Rennerfeldt, Deena A, Raminhos, Joana S., Leff, Samantha M, Manning, Pristinavae, Van Vliet, Krystyn J

“…Here we observed BMSC colony formation in real time via time lapsed optical imaging and analysis, to quantify whether and how heterogeneity emerged over multiple cell divisions spanning the duration of a typical colony formation unit assay. …”
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Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts by Calvo, Fernando, Ranftl, Romana, Hooper, Steven, Farrugia, Aaron J., Moeendarbary, Emad, Bruckbauer, Andreas, Batista, Facundo, Charras, Guillaume, Sahai, Erik

“…Cdc42EP3 is upregulated early in fibroblast activation and precedes the emergence of the highly contractile phenotype characteristic of CAFs. …”
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IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment by Clark, Amanda M, Heusey, Haley L, Griffith, Linda G, Lauffenburger, Douglas A, Wells, Alan

“…The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging as clinically detectable metastases. Pathophysiological signals can drive these tumor cells to emerge. …”
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Authentic teaching and learning through synthetic biology by Kuldell, Natalie

“…Synthetic biology is an emerging engineering discipline that, if successful, will allow well-characterized biological components to be predictably and reliably built into robust organisms that achieve specific functions. …”
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Antimicrobial Resistance in the Asia Pacific region: a meeting report by Dedon, Peter

“…The Asia Pacific region, home to two-thirds of the world's population and ten of the least developed countries, is considered a regional hot-spot for the emergence and spread of antimicrobial resistance (AMR). …”
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A model for genetic and epigenetic regulatory networks identifies rare for transcription factor induced pluripotency by Artyomov, Maxim N., Meissner, Alexander, Chakraborty, Arup K.

“…An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells for patient-specific regenerative medicine. …”
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Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus by Raman, Rahul, Tharakaraman, Kannan, Jayaraman, Akila, Sasisekharan, Ram, Shriver, Zachary H., Sasisekharan, Viswanathan

“…Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. …”
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Dissecting genomic diversity, one cell at a time by Blainey, Paul C, Quake, Stephen R

“…Emerging technologies are bringing single-cell genome sequencing into the mainstream; this field has already yielded insights into the genetic architecture and variability between cells that highlight the dynamic nature of the genome.…”
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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells by Gerosa, Luca, Chidley, Christopher, Fröhlich, Fabian, Sanchez, Gabriela, Lim, Sang Kyun, Muhlich, Jeremy, Chen, Jia-Yun, Vallabhaneni, Sreeram, Baker, Gregory J, Schapiro, Denis, Atanasova, Mariya I, Chylek, Lily A, Shi, Tujin, Yi, Lian, Nicora, Carrie D, Claas, Allison, Ng, Thomas SC, Kohler, Rainer H, Lauffenburger, Douglas A, Weissleder, Ralph, Miller, Miles A, Qian, Wei-Jun, Wiley, H Steven, Sorger, Peter K

“…© 2020 The Authors Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth of tumors but often leads to the emergence of slowly dividing persister cells, which constitute a reservoir for the selection of drug-resistant clones. …”
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The future of antibiotics begins with discovering new combinations by Zhu, Meilin, Tse, Megan W, Weller, Juliane, Chen, Julie, Blainey, Paul C

“…With limited drug development in the antibacterial space, combination therapy has emerged as a promising strategy to combat multidrug-resistant bacteria. …”
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Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function by Bao, Gang, Thomas, Wendy, Hwang, Wonmuk, Fletcher, Daniel A., Zhu, Cheng, Mofrad, Mohammad R. K., Kamm, Roger Dale, Grodzinsky, Alan J.

“…Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. …”
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mRNA-1273 and BNT162b2 COVID-19 vaccines elicit antibodies with differences in Fc-mediated effector functions by Kaplonek, Paulina, Cizmeci, Deniz, Fischinger, Stephanie, Collier, Ai-ris, Suscovich, Todd, Linde, Caitlyn, Broge, Thomas, Mann, Colin, Amanat, Fatima, Dayal, Diana, Rhee, Justin, de St Aubin, Michael, Nilles, Eric J, Musk, Elon R, Menon, Anil S, Saphire, Erica Ollmann, Krammer, Florian, Lauffenburger, Douglas A, Barouch, Dan H, Alter, Galit

“…However, differences emerged across epitope-specific responses, with higher concentrations of receptor binding domain (RBD)– and N-terminal domain–specific IgA observed in recipients of mRNA-1273. …”
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Understanding resistance to combination chemotherapy by Pritchard, Justin R., Hemann, Michael, Lauffenburger, Douglas A

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Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communities by D'Aoust, Patrick M, Tian, Xin, Towhid, Syeda Tasneem, Xiao, Amy, Mercier, Elisabeth, Hegazy, Nada, Jia, Jian-Jun, Wan, Shen, Kabir, Md Pervez, Fang, Wanting, Fuzzen, Meghan, Hasing, Maria, Yang, Minqing Ivy, Sun, Jianxian, Plaza-Diaz, Julio, Zhang, Zhihao, Cowan, Aaron, Eid, Walaa, Stephenson, Sean, Servos, Mark R, Wade, Matthew J, MacKenzie, Alex E, Peng, Hui, Edwards, Elizabeth A, Pang, Xiao-Li, Alm, Eric J, Graber, Tyson E, Delatolla, Robert

“…Furthermore, the WC ratio decreased significantly in 6 of the 7 studied locations, serving as a potential signal of the emergence of the Alpha variant of concern (VOC) in a relatively non-immunized community (40-60 % allelic proportion), while a more muted decrease in the WC ratio signaled the emergence of the Delta VOC in a relatively well-immunized community (40-60 % allelic proportion). …”
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Perspective: The promise of multi-cellular engineered living systems by Kamm, Roger D., Arora, Natasha, Griffith, Linda G., Martin, Adam C., Weiss, Ron, Yevick, Hannah G., Zaman, Muhammed H.

“…This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. …”
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Fc Glycan-Mediated Regulation of Placental Antibody Transfer by Jennewein, Madeleine F, Goldfarb, Ilona, Dolatshahi, Sepideh, Cosgrove, Cormac, Noelette, Francesca J, Krykbaeva, Marina, Das, Jishnu, Sarkar, Aniruddh, Gorman, Matthew J, Fischinger, Stephanie, Boudreau, Carolyn M, Brown, Joelle, Cooperrider, Jennifer H, Aneja, Jasneet, Suscovich, Todd J, Graham, Barney S, Lauer, Georg M, Goetghebuer, Tessa, Marchant, Arnaud, Lauffenburger, Douglas, Kim, Arthur Y, Riley, Laura E, Alter, Galit

“…While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. …”
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