Prenatal exposure of mice to the human liver carcinogen aflatoxin B by Thiantanawat, Apinya, Egner, Patricia A., Groopman, John D., Chawanthayatham, Supawadee, Wogan, Gerald N, Croy, Robert G, Essigmann, John M

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Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor by Sarkar, Ujjal, Rivera-Burgos, Dinelia, Large, Emma M., Hughes, David J., Kodihalli, Ravindra, Dyer, Rachel Lee, Ebrahimkhani, Mohammad Reza, Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven Robert

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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

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Engineering Modular 3D Liver Culture Microenvironments In Vitro to Parse the Interplay between Biophysical and Biochemical Microenvironment Cues on Hepatic Phenotypes by Wang, Alex J, Allen, Allysa, Sofman, Marianna, Sphabmixay, Pierre, Yildiz, Ece, Griffith, Linda G

“…In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. …”
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Engineering liver by Griffith, Linda G., Wells, Alan, Stolz, Donna B.

“…An explosion of micro- and nanofabrication, biomaterials, microfluidic, and other technologies potentially affords unprecedented opportunity to create microphysiological models of the human liver, but engineering design principles for how to deploy these tools effectively toward specific applications, including how to define the essential constraints of any given application (available sources of cells, acceptable cost, and user-friendliness), are still emerging. …”
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IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment by Clark, Amanda M, Heusey, Haley L, Griffith, Linda G, Lauffenburger, Douglas A, Wells, Alan

“…Using a complex <jats:italic>ex vivo</jats:italic> all-human liver microphysiological (MPS) model of dormant-emergent metastatic progression, CXCR3 ligands were found to be elevated in actively growing populations of metastatic TNBC breast cancer cells whereas they remained similar to the tumor-free hepatic niche in those with dormant breast cancer cells. …”
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Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens by Rogers, Arlin B., Fry, Rebecca C., Dedon, Peter C., Tannenbaum, Steven Robert, Schauer, David B., Essigmann, John M., McFaline, Jose Luis, Williams, Michelle V., Doernte, A. L., Fiala, Jeannette Louise Allen, Raczynski, Arkadiusz R., Theve, E. J., Feng, Yan, Fox, James G., Lemon, S. M., Weinman, S. A.

“…These results have implications for human liver cancer risk assessment and prevention.…”
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