S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration by Bhat, Vadiraja B., Seneviratne, Uthpala Indrajith, Nott, Alexander, Kodihalli, Ravindra, Wishnok, John S, Tsai, Li-Huei, Tannenbaum, Steven R

“…SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. …”
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S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration by Bhat, Vadiraja B., Seneviratnea, Uthpala, Nott, Alexi, Ravindra, Kodihalli C., Wishnok, John S, Tsai, Li-Huei, Tannenbaum, Steven R

“…SNOTRAP identified 313 endogenous SNO-sites in 251 proteins in the mouse brain, of which 135 SNO-proteins were detected only during neurodegeneration. S-nitrosation in the brain shows regional differences and becomes elevated during early stages of neurodegeneration in the CK-p25 mouse. …”
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Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma by Chen, Huihui, Cho, Kin-Sang, Vu, T. H. Khanh, Chen, Guochun, Mathew, Rose, McHam, M. Lisa, Fazelat, Ahad, Lashkari, Kameran, AU, Ngan Pan Bennett, TSE, Joyce Ka Yu, Li, Yingqian, Yu, Honghua, Yang, Lanbo, Stein-Streilein, Joan, Ma, Chi Him Eddie, Woolf, Clifford J., Jager, Martine J., Chen, Jianzhu, Chen, Dong F., Shen, Chase, Kaur, Mandeep, Fox, James G, Whary, Mark T.

“…Furthermore, retina-infiltrating T cells cross-react with human and bacterial HSPs; mice raised in the absence of commensal microflora do not develop glaucomatous T-cell responses or the associated neurodegeneration. These results provide compelling evidence that glaucomatous neurodegeneration is mediated in part by T cells that are pre-sensitized by exposure to commensal microflora.…”
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Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration by Morshed, Nader, Ralvenius, William, Nott, Alexander, Watson, Lauren Ashley, Rodriguez, Felicia H, Akay, Leyla Anne, Joughin, Brian Alan, Pao, Ping-Chieh, Penney, Jay, LaRocque, Lauren, Mastroeni, Diego, Tsai, Li‐Huei, White, Forest M.

“…Collectively, our results point to an important role for mouse Siglec-F and human Siglec-8 in regulating microglial activation during neurodegeneration.…”
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Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease by Brewster, James T., Thiabaud, Gregory D., Harvey, Peter, Zafar, Hadiqa, Reuther, James F., Dell’Acqua, Simone, Johnson, Rachel M., Root, Harrison D., Metola, Pedro, Jasanoff, Alan Pradip, Casella, Luigi, Sessler, Jonathan L.

“…The complex etiology of neurodegeneration continues to stifle efforts to develop effective therapeutics. …”
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Application of CRISPR genetic screens to investigate neurological diseases by So, Raphaella W L, Chung, Sai W, Lau, Heather H C, Watts, Jeremy J, Gaudette, Erin, Al-Azzawi, Zaid A M, Bishay, Jossana, Lin, Lilian T, Joung, Julia, Wang, Xinzhu, Schmitt-Ulms, Gerold

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Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Target... by Zacharias, Helena U., Kaleta, Christoph, Cossais, François, Schaeffer, Eva, Berndt, Henry, Best, Lena, Dost, Thomas, Glüsing, Svea, Groussin, Mathieu, Poyet, Mathilde, Heinzel, Sebastian, Bang, Corinna, Siebert, Leonard, Demetrowitsch, Tobias, Leypoldt, Frank, Adelung, Rainer, Bartsch, Thorsten, Bosy-Westphal, Anja, Schwarz, Karin, Berg, Daniela

“…This review summarizes our current knowledge on the interplay between microbiota, metabolites, and neurodegeneration along the gastrointestinal–brain axis. …”
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Extracellular Acidic pH Inhibits Oligodendrocyte Precursor Viability, Migration, and Differentiation by Jagielska, Anna, Wilhite, Kristen D., Van Vliet, Krystyn J.

“…Failure of this repair process is characteristic of neurodegeneration in demyelinating diseases such as multiple sclerosis, and it remains unclear how the lesion microenvironment contributes to decreased remyelination potential of oligodendrocytes. …”
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Retromer dysfunction in amyotrophic lateral sclerosis by Fraenkel, Ernest

“…In light of these findings, we propose that mild alterations in retromer inversely modulate neurodegeneration propensity in ALS. </jats:p>…”
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Microphysiological Neurovascular Barriers to Model the Inner Retinal Microvasculature by Maurissen, Thomas L., Pavlou, Georgios, Bichsel, Colette, Villaseñor, Roberto, Kamm, Roger D., Ragelle, Héloïse

“…In particular, the inner blood-retinal barrier (iBRB) and blood&ndash;brain barrier (BBB) share common origins in development, and similar morphology and function in adult tissue, while barrier breakdown and leakage of neurotoxic molecules can be accompanied by neurodegeneration. Therefore, pre-clinical research requires human in vitro models that elucidate pathophysiological mechanisms and support drug discovery, to add to animal in vivo modeling that poorly predict patient responses. …”
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Transcriptomic reprogramming for neuronal age reversal by Plesa, Alexandru M., Shadpour, Michael, Boyden, Ed, Church, George M.

“…We propose neural cells as particularly relevant targets for rejuvenation due to substantial impact of neurodegeneration on human frailty. Of all cell types in the brain, we argue that glutamatergic neurons, neuronal stem cells, and oligodendrocytes represent the most impactful and tractable targets. …”
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Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy by Sarkar, Souvarish, Murphy, Michael A, Dammer, Eric B, Olsen, Abby L, Rangaraju, Srikant, Fraenkel, Ernest, Feany, Mel B

“…Our integrative analysis suggested that mitochondrial dysfunction was a common downstream mediator of neurodegeneration. Accordingly, Gch1 knockdown enhanced metabolic dysfunction in α-synuclein transgenic fly brains while folate supplementation partially normalized brain bioenergetics. …”
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Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders by Nakamura, Tomohiro, Oh, Chang-ki, Zhang, Xu, Tannenbaum, Steven R, Lipton, Stuart A

“…Recently, we discovered that enzymes previously thought to act in completely disparate biochemical pathways can transnitrosylate one another during inflammaging in an unexpected manner to mediate neurodegeneration. Accordingly, we reported a concerted tricomponent transnitrosylation network from Uch-L1-to-Cdk5-to-Drp1 that mediates synaptic damage in Alzheimer's disease. …”
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Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein by Lindquist, Susan, Jasanoff, Alan Pradip, Ma, Jiyan, Wang, Xinhe, Borkowski, Andrew W., Jackson, Walker S., Faas, Henryk

“…In the cerebellum, gross neurodegeneration was accompanied by increased Mn[superscript 2+]-enhanced MRI signal, raising the possibility that compensatory mechanisms act to preserve cerebellar function in the face of massive atrophy. …”
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Polyglutamine Expanded Huntingtin Dramatically Alters the Genome-Wide Binding of HSF1 by Riva, Laura, Koeva, Martina I., Yildirim, Ferah, Pirhaji, Leila, Dinesh, Deepika, Mazor, Tali, Duennwald, Martin L., Fraenkel, Ernest

“…In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutant Htt in disease models, suggesting that the heat shock response is impaired in the disease. …”
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice by HD iPSC Consortium, Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, L Alice, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N, Kedaigle, Amanda Joy, Wasylenko, Theresa Anne, Yildirim, Ferah, Ng, Christopher W., Milani, Pamela, Housman, David E, Fraenkel, Ernest

“…Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent stem cells were used for 'omics' analyses to identify mechanisms underlying neurodegeneration. RNA-seq analysis identified genes in glutamate and GABA signaling, axonal guidance and calcium influx whose expression was decreased in HD cultures. …”
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