Biomaterial Strategies for Immunomodulation by Hotaling, Nathan A., Babensee, Julia E., Tang, Li, Irvine, Darrell J

“…Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. …”
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Antibody-Based Strategies to Prevent and Treat Influenza by Shriver, Zachary, Trevejo, Jose M., Sasisekharan, Ram

“…However, until recently, antibody-based strategies to combat infectious agents have been hampered due to the fact that most antibodies have been found to be strain specific, with the virus evolving resistance in many cases. …”
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A Barcoding Strategy Enabling Higher-Throughput Library Screening by Microscopy by Chen, Robert, Rishi, Harneet S., Yamada, Masaki R., Yeh, Vincent J., Chow, Thomas, Cheung, Celia L., Jones, Austin T., Johnson, Terry D., DeLoache, William C., Dueber, John E., Potapov, Vladimir, Keating, Amy E.

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Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature by Zhang, Shun, Wan, Zhengpeng, Kamm, Roger D

“…Here, we review recent advancements in vascularizing organoids and engineeringin vitrocapillary beds, and further explore strategies to integrate them on a microfluidic based platform, aiming for establishing perfused vasculature throughout organoidsin vitro.…”
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New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay by Wan, Zhengpeng, Floryan, Marie A, Coughlin, Mark F, Zhang, Shun, Zhong, Amy X, Shelton, Sarah E, Wang, Xun, Xu, Chenguang, Barbie, David A, Kamm, Roger D

“…The vessels close to the tumor spheroid made with this new strategy are more perfusable than the ones made with other methods. …”
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Targeting tumor cell motility as a strategy against invasion and metastasis by Wells, Alan, Grahovac, Jelena, Wheeler, Sarah, Ma, Bo, Lauffenburger, Douglas A.

“…However, these two forms of dissemination utilize some common strategies to accomplish movement from the primary tumor, establishment in an ectopic site, and survival therein. …”
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An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum by Lee, Marcus CS, Fidock, David A, Wagner, Jeffrey Charles, Goldfless, Stephen Jacob, Maddur Ganesan, Suresh, Niles, Jacquin

“…Results: Yeast homologous recombination and Gibson assembly were found to be effective strategies for successfully constructing P. falciparum plasmid vectors. …”
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Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β by Zhong, Cheng, Ramek, Alexander, Koehler, Angela Nicole

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Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology by Afonin, Kirill A, Dobrovolskaia, Marina A, Church, George, Bathe, Mark

“…Herein, we communicate discussions on the opportunities, barriers, and strategies for realizing the clinical grand challenge of TNA nanotechnology, with a focus on ways to overcome barriers to advance NANPs to the clinic.…”
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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity by Irvine, Darrell

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Public good dynamics drive evolution of iron acquisition strategies in natural bacterioplankton populations by Cordero Sanchez, Otto Xavier, Ventouras, Laure-Anne, DeLong, Edward, Polz, Martin F.

“…A common strategy among microbes living in iron-limited environments is the secretion of siderophores, which can bind poorly soluble iron and make it available to cells via active transport mechanisms. …”
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Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy by Niles, Jacquin

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A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo by Reinhardt, H. Christian, Kim, Jacob S., Ruf, Daniela M., Mitra, Tanya, Couvillon, Anthony D., Yaffe, Michael B., Cannell, Ian Gordon, Reinhardt, H. Christian, Kim, Jacob S., Ruf, Daniela M., Morandell, Sandra M., Jacks, Tyler E, Yaffe, Michael B

“…A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) in vivo. …”
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Versatile and on-demand biologics co-production in yeast by Cao, Jicong, Perez-Pinera, Pablo, Lowenhaupt, Ky, Wu, Ming-Ru, Purcell, Oliver, de la Fuente-Nunez, Cesar, Lu, Timothy K., de la Fuente Nunez, Cesar, Lu, Timothy K

“…We then use these basic strategies to produce drug mixtures as well as to separate drugs. …”
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Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease by Nagel, Zachary D., Brenner, David J., Begley, Thomas J., Sobol, Robert W., Bielas, Jason H., Stambrook, Peter J., Wei, Qingyi, Hu, Jennifer J., Terry, Mary Beth, Dilworth, Caroline, McAllister, Kimberly A., Reinlib, Les, Worth, Leroy, Shaughnessy, Daniel T., Engelward, Bevin P

“…The rise of advanced technologies for characterizing human populations at the molecular level, from sequence to function, is shifting disease prevention paradigms toward personalized strategies. Because minimization of adverse outcomes is a key driver for treatment decisions for diseased populations, developing personalized therapy strategies represent an important dimension of both precision medicine and personalized prevention. …”
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Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials by Stephan, Matthias T., Irvine, Darrell J

“…These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.…”
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Beyond antigens and adjuvants: formulating future vaccines by Moyer, Tyson, Zmolek, Andrew Charles, Irvine, Darrell J

“…The use of formulations to regulate biodistribution and promote antigen and inflammatory cue co-uptake in immune cells may be important for next-generation molecular adjuvants. Finally, strategies to program vaccine kinetics through novel formulation and delivery strategies provide another means to enhance immune responses independent of the choice of adjuvant. …”
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Engineered Microphysiological Systems for Testing Effectiveness of Cell-Based Cancer Immunotherapies by Campisi, Marco, Shelton, Sarah E., Chen, Minyue, Kamm, Roger D., Barbie, David A., Knelson, Erik H.

“…This review examines current strategies for testing cell-based cancer immunotherapies using ex vivo microphysiological systems and microfluidic technologies. …”
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Engineering New Approaches to Cancer Vaccines by Irvine, D. J., Mehta, Naveen, Moynihan, Kelly Dare

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Phenotypic Evolution of Therapeutic Salmonella enterica Serovar Typhimurium after Invasion of TRAMP Mouse Prostate Tumor by Choe, Elizabeth, Kazmierczak, Robert A., Eisenstark, Abraham

“…We posit that the Salmonella population adopts certain strategies to minimize energy consumption and maximize survival and proliferation once within the tumor. …”
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