CD73 Is Critical for the Resolution of Murine Colonic Inflammation by Bynoe, Margaret S., Waickman, Adam T., Mahamed, Deeqa A., Mueller, Cynthia, Mills, Jeffrey H., Czopik, Agnieszka

“…We conclude that CD73 expression in the colon is critical for regulating the magnitude and the resolution of colonic immune responses.…”
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SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia by Puissant, Alexandre, Alexe, Gabriela, Pikman, Yana, Bassil, Christopher F., Mehta, Swapnil, Du, Jinyan, Kazi, Julhash U., Luciano, Frédéric, Rönnstrand, Lars, Kung, Andrew L., Aster, Jon C., Galinsky, Ilene, Stone, Richard M., DeAngelo, Daniel J., Stegmaier, Kimberly, Fenouille, Nina, Hemann, Michael

“…Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. …”
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Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction by Rudenko, Andrii, Dawlaty, Meelad M., Seo, Jinsoo, Cheng, Albert W., Meng, Jia, Le, Thuc, Faull, Kym F., Jaenisch, Rudolf, Tsai, Li-Huei

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Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis by Young, Nathan P., Crowley, Denise G., Jacks, Tyler E

“…Furthermore, using in vivo RNA interference, we implicate the p53 target gene p21 as a critical mediator in this process, highlighting cell-cycle arrest as an extremely potent tumor suppressor mechanism.…”
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Cell-State Transitions Regulated by SLUG Are Critical for Tissue Regeneration and Tumor Initiation by Phillips, Sarah, Prat, Aleix, Sedic, Maja, Proia, Theresa, Wronski, Ania, Mazumdar, Sohini, Skibinski, Adam, Shirley, Stephanie H., Perou, Charles M., Gill, Grace, Kuperwasser, Charlotte, Gupta, Piyush

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Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis by Yamamura, Yasuko, Hua, Xianxin, Bergelson, Svetlana, Lodish, Harvey F

“…Our results show here that both Smad and AP-1 complexes play a critical role in TGF-β1 signaling for apoptosis.…”
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A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis by Kelsch, Wolfgang, Lin, Chia-Wei, Mosley, Colleen P., Lois, Carlos

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Critical Role of Ena/VASP Proteins for Filopodia Formation in Neurons and in Function Downstream of Netrin-1 by Lebrand, Cecile, Lanier, Lorene M., Krause, Matthias, Svitkina, Tatyana M., Borisy, Gary G., Dent, Erik W., Strasser, Geraldine A., Gertler, Frank

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Regulated proteolysis of a transcription factor complex is critical to cell cycle progression in Caulobacter crescentus by Gora, Kasia G., Cantin, Amber, Joshi, Kamal K., Wohlever, Matthew Lee, Perchuk, Barrett, Chien, Peter, 1976-, Laub, Michael T

“…Here, we show that another critical cell cycle regulator, SciP, is also degraded during the G1-S transition, but by the Lon protease. …”
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A systematic analysis of the PARP protein family identifies new functions critical for cell physiology by Vyas, Sejal, Chesarone-Cataldo, Melissa, Todorova, Tanya, Huang, Yun-Han, Chang, Paul

“…In total, we show that PARP proteins are critical regulators of eukaryotic physiology.…”
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Sinorhizobium meliloti CpdR1 is critical for coordinating cell-cycle progression and the symbiotic chronic infection by Kobayashi, Hajime, De Nisco, Nicole J., Chien, Peter, Simmons, Lyle A., Walker, Graham C.

“…Thus, we demonstrate that CpdR1 mediates the co-ordination of cell cycle events, which are critical for both the free-living cell division and the differentiation required for the chronic intracellular infection.…”
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A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis by Lesch, Bluma J., Dokshin, Gregoriy A., Young, Richard A., McCarrey, John R., Page, David C

“…Here we report that a set of developmentally critical genes is maintained in an epigenetically poised (bivalent) state from embryonic stages through the end of meiosis. …”
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CD8α[superscript +] Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites by Mashayekhi, Mona, Sandau, Michelle M., Dunay, Ildiko R., Frickel, Eva M., Khan, Asis, Goldszmid, Romina S., Sher, Alan, Murphy, Theresa L., Sibley, L. David, Murphy, Kenneth M., Ploegh, Hidde

“…These results reveal that the function of CD8α[superscript +] DCs extends beyond a role in cross-presentation and includes a critical role for activation of innate immunity through IL-12 production during T. gondii infection.…”
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The Highly Conserved Bacterial RNase YbeY Is Essential in Vibrio cholerae, Playing a Critical Role in Virulence, Stress Regulation, and RNA Processing by Vercruysse, Maarten, Koehrer, Caroline, Davies, Bryan W., Arnold, Markus F. F., Mekalanos, John J., Walker, Graham C., Rajbhandary, Uttam L

“…YbeY, a highly conserved protein, is an RNase in E. coli and plays key roles in both processing of the critical 3′ end of 16 S rRNA and in 70 S ribosome quality control under stress. …”
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Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders by Brennand, Kristen J., Marchetto, M. Carol, Benvenisty, Nissim, Brustle, Oliver, Ebert, Allison, Izpisua Belmonte, Juan Carlos, Kaykas, Ajamete, Lancaster, Madeline A., Livesey, Frederick J., McConnell, Michael J., McKay, Ronald D., Morrow, Eric M., Muotri, Alysson R., Panchision, David M., Rubin, Lee L., Sawa, Akira, Soldner, Frank, Song, Hongjun, Studer, Lorenz, Temple, Sally, Vaccarino, Flora M., Wu, Jun, Vanderhaeghen, Pierre, Gage, Fred H., Jaenisch, Rudolf

“…Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.…”
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Polycomb Group Proteins Set the Stage for Early Lineage Commitment by Surface, Lauren Elizabeth, Thornton, Seraphim R., Boyer, Laurie Ann

“…Precise control of gene expression patterns is critical for the specification of cellular diversity during metazoan development. …”
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Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1 by Wu, Chuan, Yosef, Nir, Thalhamer, Theresa, Zhu, Chen, Xiao, Sheng, Kishi, Yasuhiro, Regev, Aviv, Kuchroo, Vijay K.

“…T[subscript H]17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly proinflammatory cells that are critical for clearing extracellular pathogens and for inducing multiple autoimmune diseases. …”
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The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions by Shibue, Tsukasa, Brooks, Mary W., Inan, M. Fatih, Reinhardt, Ferenc, Weinberg, Robert A

“…Hence, the formation of FLPs represents a critical rate-limiting step for the subsequent development of macroscopic metastases. …”
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Structural insights into LINC complexes by Kutay, Ulrike, Schwartz, Thomas, Sosa, Brian A.

“…Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. …”
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Conserved Bacterial RNase YbeY Plays Key Roles in 70S Ribosome Quality Control and 16S rRNA Maturation by Davies, Bryan W., Koehrer, Caroline, Walker, Graham C., Jacob, Asha I, Rajbhandary, Uttam L

“…Quality control of ribosomes is critical for cellular function since protein mistranslation leads to severe physiological consequences. …”
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