METabolic Adaptations in the Tumor MYCroenvironment by Vander Heiden, Matthew G., Davidson, Shawn Michael, Vander Heiden, Matthew G.

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The genomic basis of adaptive evolution in threespine sticklebacks by Lander, Eric Steven

“…Marine stickleback fish have colonized and adapted to thousands of streams and lakes formed since the last ice age, providing an exceptional opportunity to characterize genomic mechanisms underlying repeated ecological adaptation in nature. …”
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The genomic substrate for adaptive radiation in African cichlid fish by Lander, Eric Steven

“…Cichlid fishes are famous for large, diverse and replicated adaptive radiations in the Great Lakes of East Africa. …”
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Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression by Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L., Abraham, Brian J., Kwiatkowski, Nicholas, Buczkowski, Kevin A., Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L., Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, Tae-Jung, Hong, Sook-Hee, Poudel-Neupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J., Watanabe, Hideo, Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin, Hammerman, Peter S.

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Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells by Chen, Pan-Yu, Muzumdar, Mandar, Dorans, Kimberly, Robbins, Rebecca, Bhutkar, Arjun, Del Rosario, Amanda M, Mertins, Philipp, Qiao, Jana, Schafer, Anette Claudia, Gertler, Frank, Carr, Steven A, Jacks, Tyler E

“…Overall, our results call into question the degree to which PDAC cells are addicted to activated KRAS, by illustrating adaptive nongenetic and nontranscriptional mechanisms of resistance to Kras blockade. …”
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Adaptive mechanisms of plant specialized metabolism connecting chemistry to function by Weng, Jing-Ke, Lynch, Joseph H, Matos, Jason O, Dudareva, Natalia

“…To achieve optimal multifunctionality of diverse specialized metabolic processes, plants use various adaptive mechanisms at subcellular, cellular, tissue, organ and interspecies levels. …”
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Adaptive Evolution and the Birth of CTCF Binding Sites in the Drosophila Genome by Chen, Sidi, Ni, Xiaochun, Long, Manyuan, Negre, Nicolas, Zhang, Yong E., White, Kevin P.

“…Although the binding preference for CTCF is highly conserved, we find that CTCF binding itself is highly evolutionarily dynamic and has adaptively evolved. Between species, binding divergence increased linearly with evolutionary distance, and CTCF binding profiles are diverging rapidly at the rate of 2.22% per million years (Myr). …”
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Rapid Evolution of Culture-Impaired Bacteria during Adaptation to Biofilm Growth by Penterman, Jon, Nguyen, Dao, Anderson, Erin, Staudinger, Benjamin J., Greenberg, Everett P., Lam, Joseph S., Singh, Pradeep K.

“…Thus, a biofilm-mediated adaptation produces a stark fitness trade-off that compromises bacterial survival in culture. …”
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Determinants of Divergent Adaptation and Dobzhansky-Muller Interaction in Experimental Yeast Populations by Anderson, James B., Funt, Jason, Thompson, Dawn Anne, Prabhu, Snehit, Socha, Amanda, Sirjusingh, Caroline, Dettman, Jeremy R., Parreiras, Lucas, Guttman, David S., Regev, Aviv, Kohn, Linda M.

“…Divergent adaptation can be associated with reproductive isolation in speciation [1]. …”
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Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids by Li, Zhijie, Sun, Fang, Chen, Sidi, Rothe, Michael, Menzel, Ralph, Ma, Dengke, Lu, Alice Y., Horvitz, Howard Robert, Sun, Fei, S.B. Massachusetts Institute of Technology

“…Cells adapt to temperature shifts by adjusting levels of lipid desaturation and membrane fluidity. …”
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Durable antitumor responses to CD47 blockade require adaptive immune stimulation by Sockolosky, Jonathan T., Ho, Chia Chi M., Almo, Steven C., Garcia, K. Christopher, Dougan, Michael, Kauke, Monique Jacqueline, Ploegh, Hidde, Ingram, Jessica R.

“…Our results highlight an underappreciated contribution of the adaptive immune system to anti-CD47 adjuvant therapy and suggest that targeting both innate and adaptive immune checkpoints can potentiate the vaccinal effect of antitumor antibody therapy.…”
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Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet by Cheng, Chia-Wei, Gunduz, Nuray, Eng, George M, Tripathi, Surya, Calibasi Kocal, Gizem, Rickelt, Steffen, Moreno, Marta, Iqbal, Ameena M., Bauer-Rowe, Khristian E., Imada, Shinya, Ulutas, Mehmet Sefa, Mylonas, Konstantinos, Whary, Mark T., Hynes, Richard O, Boyer, Laurie Ann, Fox, James G, Regev, Aviv, Yilmaz, Omer H.

“…These findings reveal how control of βOHB-activated signaling in ISCs by diet helps to fine-tune stem cell adaptation in homeostasis and injury. Ketone body metabolites inform intestinal stem cell decisions in response to diverse diets.…”
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Flavin-Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB by Hamill, Michael J., Jost, Marco, Wong, Cintyu, Elliott, Sean J., Drennan, Catherine L

“…The process known as “adaptive response” allows Escherichia coli to respond to small doses of DNA-methylating agents by upregulating the expression of four proteins. …”
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Adapting to life at the end of the line: How Drosophila telomeric retrotransposons cope with their job by Pardue, Mary-Lou, DeBaryshe, P. G.

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Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation by Jarosz, Daniel F., Lindquist, Susan

“…However, the nature and adaptive value of Hsp90-contingent traits remain uncertain. …”
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Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families by Capra, Emily Jordan, Perchuk, Barrett, Skerker, Jeffrey M., Laub, Michael T.

“…Orthologous proteins often harbor numerous substitutions, but whether these differences result from neutral or adaptive processes is usually unclear. To tackle this challenge, we examined the divergent evolution of a model bacterial signaling pathway comprising the kinase PhoR and its cognate substrate PhoB. …”
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Protein kinase A regulates gene-specific translational adaptation in differentiating yeast by Vaidyanathan, Pavanapuresan P., Zinshteyn, Boris, Thompson, Mary Katherine, Gilbert, Wendy

“…Here we investigate translational reprogramming in yeast during cellular adaptation to the absence of glucose, a stimulus that induces invasive filamentous differentiation. …”
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Tolerance and adaptive evolution of triacylglycerol-producing Rhodococcus opacus to lignocellulose-derived inhibitors by Kurosawa, Kazuhiko, Laser, Josephine, Sinskey, Anthony J

“…Adapted mutants were generated on defined agar media containing lignin, 4-HB, and syringaldehyde. …”
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Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation by Schmidt, Leah Marie, Eskiocak, Banu, Kohn, Ryan, Dang, Celeste, Joshi, Nikhil, DuPage, Michel J., Lee, Da-Yae, Jacks, Tyler E

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Transcriptome response of high- and low-light-adapted Prochlorococcus strains to changing iron availability by Thompson, Anne W., Huang, Katherine H., Saito, Mak A., Chisholm, Sallie (Penny)

“…These genes are interesting targets for studying the adaptation of natural Prochlorococcus assemblages to local iron conditions as they show more diversity than other genomic regions in environmental metagenomic databases.…”
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