Silent memory engrams as the basis for retrograde amnesia by Roy, Dheeraj, Muralidhar, Shruti, Smith, Lillian, Tonegawa, Susumu

“…Memory engrams are retained under protein synthesis inhibition-induced retrograde amnesia. These engram cells can be activated by optogenetic stimulation for full-fledged recall, but not by stimulation using natural recall cues (thus, amnesia). …”
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Engram cells retain memory under retrograde amnesia by Ryan, Tomas John, Roy, Dheeraj, Pignatelli di Spinazzola, Michele, Arons, Autumn, Tonegawa, Susumu

“…Although these properties are lacking in engram cells under protein synthesis inhibitor–induced amnesia, direct optogenetic activation of these cells results in memory retrieval, and this correlates with retained engram cell–specific connectivity. …”
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Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease by Roy, Dheeraj, Arons, Autumn, Mitchell, Teryn, Pignatelli di Spinazzola, Michele, Ryan, Tomas John, Tonegawa, Susumu

“…However, it has been uncertain whether the observed amnesia in the early stages of AD is due to disrupted encoding and consolidation of episodic information, or an impairment in the retrieval of stored memory information. …”
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Hippocampal CA3 Output Is Crucial for Ripple-Associated Reactivation and Consolidation of Memory by Tonegawa, Susumu, Nakashiba, Toshiaki, Buhl, Derek L., McHugh, Thomas J.

“…Although posttraining HPC lesions result in temporally graded amnesia, the precise HPC circuits and mechanisms involved in remote memory storage remain poorly understood. …”
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Development of schemas revealed by prior experience and NMDA receptor knock-out by Dragoi, George, Tonegawa, Susumu

“…These results reveal the existence of distinct neuronal encoding schemes which could explain why hippocampal dysfunction results in anterograde amnesia while sparing recollection of old, schema-based memories.…”
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Selection of preconfigured cell assemblies for representation of novel spatial experiences by Dragoi, George, Tonegawa, Susumu

“…The hippocampus is a brain area necessary for normal internally generated spatial–temporal representations and its dysfunctions have resulted in anterograde amnesia, impaired imagining of new experiences, and hallucinations. …”
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