Emerging Biological Principles of Metastasis by Lambert, Arthur W., Pattabiraman, Diwakar R., Weinberg, Robert A

“…In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.…”
Get full text
Get full text

An emerging role of mTOR in lipid biosynthesis by Laplante, Mathieu, Sabatini, David

Get full text
Get full text

Emerging Roles for Natural MicroRNA Sponges by Ebert, Margaret S., Sharp, Phillip A.

Get full text
Get full text

Emerging concepts: linking hypoxic signaling and cancer metabolism by Lyssiotis, C A, Muñoz-Pinedo, C, Emerling, B M, Vander Heiden, Matthew G.

Get full text
Get full text

Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite by Park, Sun-Yang, Rao, Chitong, Coyte, Katharine Z, Kuziel, Gavin A, Zhang, Yancong, Huang, Wentao, Franzosa, Eric A, Weng, Jing-Ke, Huttenhower, Curtis, Rakoff-Nahoum, Seth

“…Here, we reveal that fitness of the Bacteroidales, the dominant order of bacteria in the human gut, is an emergent property of glycans and one specific metabolite, butyrate. …”
Get full text

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models by Whitesell, Luke, Santagata, Sandro, Mendillo, Marc L., Lin, Nancy U., Proia, David A., Lindquist, Susan

“…Efforts to block the emergence of resistance have met with limited success, largely because the mechanisms underlying it are so varied and complex. …”
Get full text
Get full text

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression by Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L., Abraham, Brian J., Kwiatkowski, Nicholas, Buczkowski, Kevin A., Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L., Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, Tae-Jung, Hong, Sook-Hee, Poudel-Neupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J., Watanabe, Hideo, Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin, Hammerman, Peter S.

“…These findings suggest that the addition of THZ1 to targeted therapies is a promising broad-based strategy to hinder the emergence of drug-resistant cancer cell populations. …”
Get full text

Biomolecular Condensates in the Nucleus by Sabari, Benjamin R, Dall’Agnese, Alessandra, Young, Richard A

“…These condensates have common features and emergent properties that provide the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms. …”
Get full text

Cryo-EM at ACA 2022 by Subramaniam, Sriram, Kotecha, Abhay, Davis, Joseph H

“…The 2022 meeting of the American Crystallographic Association in Portland was an inspiring event, addressing a range of both conventional and emerging themes in structural biology. The increasing emphasis at the conference on methods outside the conventional envelope of crystallography, especially cryo-electron microscopy, is discussed.…”
Get full text

Paired exome analysis of Barrett's esophagus and adenocarcinoma by Stachler, Matthew D, Taylor-Weiner, Amaro, Peng, Shouyong, McKenna, Aaron, Agoston, Agoston T, Odze, Robert D, Davison, Jon M, Nason, Katie S, Loda, Massimo, Leshchiner, Ignaty, Stewart, Chip, Stojanov, Petar, Seepo, Sara, Lawrence, Michael S, Ferrer-Torres, Daysha, Lin, Jules, Chang, Andrew C, Gabriel, Stacey B, Beer, David G, Getz, Gad, Carter, Scott L, Bass, Adam J, Lander, Eric Steven

“…These data suggest that many EACs emerge not through gradual accumulation of tumor suppressor alterations but rather through a more direct path whereby a TP53-mutant cell undergoes genome doubling, followed by acquisition of oncogenic amplifications.…”
Get full text

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia by Baryawno, Ninib, Przybylski, Dariusz, Kowalczyk, Monika S., Kfoury, Youmna, Severe, Nicolas, Gustafsson, Karin, Kokkaliaris, Konstantinos D., Mercier, Francois, Tabaka, Marcin, Hofree, Matan, Dionne, Danielle, Papazian, Ani, Lee, Dongjun, Ashenberg, Orr, Subramanian, Ayshwarya, Vaishnav, Eeshit Dhaval, Rozenblatt-Rosen, Orit, Regev, Aviv, Scadden, David T.

“…Our taxonomy of the stromal compartment provides a comprehensive bone marrow cell census and experimental support for cancer cell crosstalk with specific stromal elements to impair normal tissue function and thereby enable emergent cancer.…”
Get full text

The Centrality of RNA by Sharp, Phillip A.

“…New roles for RNAs in biology continue to emerge, and a glance at the history of RNAs may prepare molecular biologists for future discoveries about these powerful molecules. …”
Get full text
Get full text

Nutrient-Sensing Mechanisms across Evolution by Chantranupong, Lynne, Wolfson, Rachel Laura, Sabatini, David

“…We discuss how these mechanisms reflect the nutrient requirements of specific species and how they have adapted to the emergence of multicellularity in eukaryotes.…”
Get full text
Get full text
Get full text
Get full text

Paired exome analysis of Barrett's esophagus and adenocarcinoma by Stachler, Matthew D, Taylor-Weiner, Amaro, Peng, Shouyong, McKenna, Aaron, Agoston, Agoston T, Odze, Robert D, Davison, Jon M, Nason, Katie S, Loda, Massimo, Leshchiner, Ignaty, Stewart, Chip, Stojanov, Petar, Seepo, Sara, Lawrence, Michael S, Ferrer-Torres, Daysha, Lin, Jules, Chang, Andrew C, Gabriel, Stacey B, Beer, David G, Getz, Gad, Carter, Scott L, Bass, Adam J, Lander, Eric Steven

“…These data suggest that many EACs emerge not through the gradual accumulation of tumor-suppressor alterations but rather through a more direct path whereby a TP53-mutant cell undergoes genome doubling, followed by the acquisition of oncogenic amplifications.…”
Get full text

lincRNAs: Genomics, Evolution, and Mechanisms by Ulitsky, Igor, Bartel, David

“…This Review outlines the emerging understanding of lincRNAs in vertebrate animals, with emphases on how they are being identified and current conclusions and questions regarding their genomics, evolution and mechanisms of action.…”
Get full text
Get full text

Evolving a robust signal transduction pathway from weak cross-talk by Siryaporn, Albert, Perchuk, Barrett, Laub, Michael T

“…We show that by combining a small number of mutations in CpxA that individually increase phosphorylation of the non-partner RR OmpR, phosphatase activity against phospho-OmpR emerges. The resulting circuit also becomes responsive to input signal to CpxA. …”
Get full text
Get full text

Evolving a robust signal transduction pathway from weak cross-talk by Siryaporn, Albert, Goulian, Mark, Perchuk, Barrett, Laub, Michael T

“…We show that by combining a small number of mutations in CpxA that individually increase phosphorylation of the non‐partner RR OmpR, phosphatase activity against phospho‐OmpR emerges. The resulting circuit also becomes responsive to input signal to CpxA. …”
Get full text
Get full text

Blood and immune development in human fetal bone marrow and Down syndrome by Regev, Aviv

“…Haematopoiesis first emerges in human BM at 11-12 weeks after conception1,2, yet almost nothing is known about how fetal BM (FBM) evolves to meet the highly specialized needs of the fetus and newborn. …”
Get full text

Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19 by Spranger, Stefani

“…The Society for Immunotherapy of Cancer (SITC) stands along with and supports our colleagues in emergency departments, intensive care units (ICUs) and inpatient wards in the global effort to overcome this unprecedented pandemic. ©2020…”
Get full text

Toxoplasma gondii effectors are master regulators of the inflammatory response by Melo, Mariane Bandeira, Saeij, Jeroen, Jensen, Kirk D.

“…Here we review the latest developments in our understanding of how Toxoplasma counteracts the immune response of the host, and in some cases provokes it, through the use of specific parasite effector proteins. An emerging theme from these discoveries is that Toxoplasma effectors are master regulators of the pro-inflammatory response, which elicits many of the toxoplasmacidal mechanisms of the host. …”
Get full text