Genetics of germ cell development by Lesch, Bluma J., Page, David C

“…The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. …”
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Retinoic Acid and Germ Cell Development in the Ovary and Testis by Endo, Tsutomu, Mikedis, Maria M., Nicholls, Peter K., Page, David C, de Rooij, Dirk G.

“…These gametes derive from primordial germ cells, which colonize the nascent gonad, and later undertake sexual differentiation to produce oocytes or sperm. …”
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Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling by Hu, Yueh-Chiang, Nicholls, Peter K., Soh, Ying Qi Shirleen, Daniele, Joseph R., Junker, Jan Philipp, van Oudenaarden, Alexander, Page, David C

“…In mouse embryos at mid-gestation, primordial germ cells (PGCs) undergo licensing to become gametogenesis-competent cells (GCCs), gaining the capacity for meiotic initiation and sexual differentiation. …”
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A transitory signaling center controls timing of primordial germ cell differentiation by Banisch, Torsten U, Slaidina, Maija, Gupta, Selena, Ho, Megan, Gilboa, Lilach, Lehmann, Ruth

“…During Drosophila ovary morphogenesis, primordial germ cells (PGCs) either are sequestered in stem cell niches and are maintained in an undifferentiated germline stem cell state or transition directly toward differentiation. …”
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Dynamic and regulated TAF gene expression during mouse embryonic germ cell development by Gura, Megan A., Mikedis, Maria M., Seymour, Kimberly A., de Rooij, Dirk G., Page, David C, Freiman, Richard N.

“…The expression of several of these germ cell-enriched TFIID genes is dependent upon Dazl and/or Stra8, known regulators of germ cell development and meiosis. …”
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A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes by Carmell, Michelle A, Dokshin, Gregoriy A, Skaletsky, Helen, Hu, Yueh-Chiang, van Wolfswinkel, Josien C, Igarashi, Kyomi J, Bellott, Daniel W, Nefedov, Michael, Enders, George C, Uversky, Vladimir N, Mello, Craig C, Reddien, Peter, Page, David C

“…We report an ancient family of GCNA (germ cell nuclear antigen) proteins that arose in the earliest eukaryotes, and feature a rapidly evolving intrinsically disordered region (IDR). …”
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Dppa3 / Pgc7 / stellais a maternal factor and is not required for germ cell specification in mice by Bortvin, Alex, Goodheart, Mary L., Liao, Michelle, Page, David C.

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Mir-290–295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects by Medeiros, Lea Ann, Dennis, Lucas M., Gill, Mark E., Houbaviy, Hristo, Markoulaki, Styliani, Fu, Dongdong, White, Amy C., Kirak, Oktay, Sharp, Phillip A., Jaenisch, Rudolf, Page, David C

“…Male mir-290–295−/− mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. …”
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The Ligand Binding Domain of GCNF Is Not Required for Repression of Pluripotency Genes in Mouse Fetal Ovarian Germ Cells by Okumura, Leah M., Lesch, Bluma J., Page, David C.

“…In mice, successful development and reproduction require that all cells, including germ cells, transition from a pluripotent to a differentiated state. …”
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Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells by Gill, Mark E., Hu, Yueh-Chiang, Lin, Yanfeng, Page, David C

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A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis by Lesch, Bluma J., Dokshin, Gregoriy A., Young, Richard A., McCarrey, John R., Page, David C

“…In multicellular organisms, germ cells carry the hereditary material from one generation to the next. …”
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Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro by Chu, Li-Fang, Surani, M. Azim, Jaenisch, Rudolf, Zwaka, Thomas P.

“…Single-cell gene expression profiling indicated that many of these Blimp1-positive cells coexpress other genes typically associated with early germ cell specification. When genetically traced in vitro, these cells acquired properties normally associated with primordial germ cells. …”
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Poised chromatin in the mammalian germ line by Lesch, B. J., Page, David C

“…We hypothesize that the poised chromatin state is essential for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. …”
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The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO by Boulias, Konstantinos, Horvitz, Howard Robert

“…The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine. …”
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A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians by Issigonis, Melanie, Redkar, Akshada B, Rozario, Tania, Khan, Umair W, Mejia-Sanchez, Rosa, Lapan, Sylvain W, Reddien, Peter W, Newmark, Phillip A

“…We find that yolk cells display germ cell–like attributes and that vitellaria are structurally analogous to gonads. …”
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Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice by Hu, Yueh-Chiang, de Rooij, Dirk G., Page, David C

“…We conditionally disrupted the Rb gene in mouse germ cells in vivo and discovered unanticipated consequences for GFRa1-protein-expressing A[subscript single] (GFRa1[superscript +] A[subscript s]) spermatogonia, the major source of male germ-line stem cells. …”
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Gamete Formation Resets the Aging Clock in Yeast by Unal, Elcin, Amon, Angelika B

“…Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. …”
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A single-cell atlas reveals unanticipated cell type complexity in Drosophila ovaries by Slaidina, Maija, Gupta, Selena, Banisch, Torsten U, Lehmann, Ruth

“…We computed transcriptional signatures and identified specific markers for nine states of germ cell differentiation and 23 somatic cell types and subtypes. …”
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Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion by Piccolo, Francesco M., Bagci, Hakan, Brown, Karen E., Landeira, David, Soza-Ried, Jorge, Feytout, Amelie, Mooijman, Dylan, Hajkova, Petra, Leitch, Harry G., Tada, Takashi, Kriaucionis, Skirmantas, Dawlaty, Meelad M., Jaenisch, Rudolf, Merkenschlager, Matthias, Fisher, Amanda G.

“…Differential DNA methylation at imprinted control regions (ICRs) is established in gametes and, although largely preserved through development, can be experimentally reset by fusing somatic cells with embryonic germ cell (EGC) lines. Here, we show that the Ten-Eleven Translocation proteins Tet1 and Tet2 participate in the efficient erasure of imprints in this model system. …”
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Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions by Miller, Matthew P., Unal, Elcin, Brar, Gloria A., Amon, Angelika B

“…Determining how this unusual chromosome segregation behavior is established is central to understanding germ cell development. Here we show that preventing microtubule–kinetochore interactions during premeiotic S phase and prophase I is essential for establishing the meiosis I chromosome segregation pattern. …”
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