Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis by Gupton, Stephanie L., Gertler, Frank

“…A second mechanism occurs in the presence of laminin through integrin-dependent activation of FAK and src, and utilizes coordinated activity of the Arp2/3 complex and VAMP7-mediated exocytosis. …”
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Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis by Gupton, Stephanie L., Gertler, Frank

“…A second mechanism occurs in the presence of laminin through integrin-dependent activation of FAK and src and uses coordinated activity of the Arp2/3 complex and VAMP7-mediated exocytosis. …”
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Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors by Begum, Shahinoor, Murphy, Patrick Andries, Hynes, Richard O

“…Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin substrate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth. …”
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An Integrin-Linked Machinery of Cytoskeletal Regulation that Enables Experimental Tumor Initiation and Metastatic Colonization by Shibue, Tsukasa, Brooks, Mary W., Weinberg, Robert A

“…Here, we identify the signaling pathway governing FLP lifetime, which involves integrin-linked kinase (ILK) and β-parvin, two integrin:actin-bridging proteins that block cofilin-mediated actin-filament severing. …”
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Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation by Case, Lindsay B, De Pasquale, Milagros, Henry, Lisa, Rosen, Michael K

“…<jats:p>Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. …”
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In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling by Miller, Peter G., Al-Shahrour, Fatima, Hartwell, Kimberly A., Chu, Lisa P., Jaras, Marcus, Puram, Rishi V., Puissant, Alexandre, Callahan, Kevin P., Ashton, John, McConkey, Marie, Poveromo, Luke P., Cowley, Glenn S., Kharas, Michael G., Labelle, Myriam, Shterental, Sebastian, Fujisaki, Joji, Silberstein, Lev, Alexe, Gabriela, Al-Hajj, Muhammad A., Shelton, Christopher A., Armstrong, Scott A., Root, David E., Scadden, David T., Mukherjee, Siddhartha, Stegmaier, Kimberly, Jordan, Craig T., Ebert, Benjamin L., Hynes, Richard O

“…We used an in vivo small hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo and for human leukemia cells in xenotransplantation studies. …”
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Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells by Bierie, Brian, Pierce, Sarah E., Kroeger, Cornelia, Stover, Daniel G., Pattabiraman, Diwakar R., Thiru, Prathapan, Liu Donaher, Joana, Reinhardt, Ferenc, Chaffer, Christine L., Keckesova, Zuzana, Weinberg, Robert A

“…Indeed, we find that a basal epithelial marker, integrin- β4 (ITGB4), can be used to enable stratification of mesenchymallike triple-negative breast cancer (TNBC) cells that differ from one another in their relative tumorigenic abilities. …”
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Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs by Toraskar, Jimita, Redvers, Richard P., Valla, Marit, Magnussen, Synnøve N., Bofin, Anna M., Opdahl, Signe, Lundgren, Steinar, Eckhardt, Bedrich L., Doherty, Judy, Anderson, Robin L., Svineng, Gunbjørg, Steigedal, Tonje, Lamar, John, Hynes, Richard O.

“…We found that NPNT promotes adhesion and anchorage-independent growth via its integrin-binding and enhancer motifs and that enforced expression in breast tumor cells promotes their colonization of the lungs. …”
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αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration by Gertler, Frank, Worth, Daniel C., Hodivala-Dilke, Kairbaan, Robinson, Stephen D., King, Samantha J., Morton, Penny E., Humphries, Martin J., Parsons, Maddy

“…Integrins are fundamental to the control of protrusion and motility in adherent cells. …”
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An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia by Li, Longxuan, Welser-Alves, Jennifer, van der Flier, Arjan, Boroujerdi, Amin, Milner, Richard, Hynes, Richard O

“…In the hypoxic adult central nervous system (CNS), fibronectin is induced on angiogenic vessels, and endothelial cells show strong induction of the two fibronectin receptors α5β1 and αvβ3 integrins. In a previous study, we found that the αvβ3 integrin is dispensable for hypoxic-induced cerebral angiogenesis, but a role for the endothelial α5β1 integrin was suggested. …”
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Integrin beta(1)-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs by Shibue, Tsukasa, Weinberg, Robert A

“…Activation of FAK in these metastatic cells depends on expression of the β1 subunit of integrins, and proliferation of these cells after extravasation in the lungs is diminished by knocking down the expression of either FAK or integrin β1. …”
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α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo by Turner, Christopher J., Badu-Nkansah, Kwabena, Crowley, Denise G., van der Flier, Arjan, Hynes, Richard O

“…The RGD-binding α5 and αv integrins have been shown to be key regulators of vascular smooth muscle cell (vSMC) function in vitro. …”
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αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells by Acharya, Mridu, Sokolovska, Anna, Tam, Jenny M., Conway, Kara L., Stefani, Caroline, Raso, Fiona, Mukhopadhyay, Subhankar, Feliu, Marianela, Paul, Elahna, Savill, John, Hynes, Richard O., Xavier, Ramnik J., Vyas, Jatin M., Stuart, Lynda M., Lacy-Hulbert, Adam, Hynes, Richard O.

“…Integrin signalling triggers cytoskeletal rearrangements, including endocytosis and exocytosis of integrins and other membrane proteins. …”
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Integrin alpha 5 beta 1 is necessary for regulation of radial migration of cortical neurons during mouse brain development by Marchetti, Giovanni, Escuin, Sarah, van der Flier, Arjan, De Arcangelis, Adele, Georges-Labouesse, Elisabeth, Hynes, Richard O

“…Several integrin heterodimers are present during formation of the cortical layers. …”
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RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion by Lafuente, Esther M., Krause, Matthias, Carman, Christopher V., Freeman, Gordon J., Berezovskaya, Alla, Constantine, Erica, Springer, Timothy A., Boussiotis, Vassiliki A., Gertler, Frank, van Puijenbroek, Andre A.F.L.

“…The small GTPase Rap1 induces integrin-mediated adhesion and changes in the actin cytoskeleton. …”
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The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions by Shibue, Tsukasa, Brooks, Mary W., Inan, M. Fatih, Reinhardt, Ferenc, Weinberg, Robert A

“…We find that the formation of elongated integrin β1-containing adhesion plaques by cancer cells that have extravasated into the lung parenchyma enables the proliferation of these cells via activation of focal adhesion kinase. …”
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Essential roles of fibronectin in the development of the left–right embryonic body plan by Pulina, Maria V., Hou, Shuan-Yu, Mittal, Ashok, Julich, Dorthe, Whittaker, Charlie A., Holley, Scott A., Astrof, Sophie, Whittaker, Charles A., Hynes, Richard O

“…Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left–right axis of asymmetry in vertebrates.…”
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Metastatic Cells Will Take Any Help They Can Get by Hynes, Richard O

“…First, monocyte/macrophages expressing α4 integrin bind VCAM-1 and provide survival signals enhancing establishment of metastases. …”
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A role for PVRL4-driven cell-cell interactions in tumorigenesis by Pallasch, Christian, Braun, Christian Joerg, Hemann, Michael, Pavlova, Natalya N., Elia, Andrew E. H., Westbrook, Thomas F., Elledge, Stephen J.

“…PVRL4 promotes anchorage-independence by driving cell-to-cell attachment and matrix-independent integrin β4/SHP-2/c-Src activation. Solid tumors frequently have copy number gains of the PVRL4 locus and some have focal amplifications. …”
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Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks by Regev, Aviv, Immunological Genome Project Consortium

“…Poorly studied podoplanin (gp38)-negative CD31− LNSCs showed similarities to FRCs but lacked expression of interleukin 7 (IL-7) and were identified as myofibroblastic pericytes that expressed integrin α7. Together our data comprehensively describe the transcriptional characteristics of LNSC subsets.…”
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