Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma by Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo

“…Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18) translocation and mutations affecting the epigenome. …”
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E., Young, Richard A.

“…Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. …”
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In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression by Ho, Emily E., Dubrovsky, Esther, Gertler, Frank, Meacham, Corbin Elizabeth, Hemann, Michael

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing by Lander, Eric Steven

“…To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. …”
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Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model by Bric, Anka, Miething, Cornelius, Bialucha, Carl Uli, Scuoppo, Claudio, Zender, Lars, Krasnitz, Alexander, Xuan, Zhenyu, Zuber, Johannes, Wigler, Michael, Hicks, James, McCombie, Richard W., Hemann, Michael, Hannon, Gregory J., Powers, Scott, Lowe, Scott W.

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Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies by Schweighofer, C. D., Abruzzo, L., Frenzel, Lukas P., Wendtner, C. M., Leskov, Ilya B., Pallasch, Christian, Drake, Adam, Iliopoulou, Bettina P., Souza, A., Shen, C.-H., Hemann, Michael, Chen, Jianzhu

“…As a proof of principle, we used this model to show that the anti-CD52 antibody alemtuzumab effectively eliminates lymphoma cells from the spleen, liver and peripheral blood, but not from the brain. …”
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Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers by Tonomura, Noriko, Elvers, Ingegerd, Thomas, Rachael, Megquier, Kate, Turner-Maier, Jason, Howald, Cedric, Sarver, Aaron L., Swofford, Ross, Frantz, Aric M., Ito, Daisuke, Mauceli, Evan, Arendt, Maja, Noh, Hyun Ji, Koltookian, Michele, Biagi, Tara, Fryc, Sarah, Williams, Christina, Avery, Anne C., Kim, Jong-Hyuk, Barber, Lisa, Burgess, Kristine, Karlsson, Elinor K., Azuma, Chieko, Modiano, Jaime F., Breen, Matthew, Lindblad-Toh, Kerstin, Lander, Eric Steven

“…Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. …”
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T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell by Serwold, T., Hochedlinger, K., Swindle, J., Hedgpeth, J., Weissman, I. L., Jaenisch, Rudolf

“…Surprisingly, ≈50% of mice with prerearranged TCR genes develop spontaneous T cell lymphomas, which originate in the thymus. The lymphomas arise from developing T cells, and contain activated Notch1, similar to most human and mouse T-cell acute lymphoblastic lymphomas. …”
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T-cell death following immune activation is mediated by mitochondria-localized SARM by Panneerselvam, P., Singh, L. P., Selvarajan, V., Chng, W. J., Ng, S. B., Tan, N. S., Ho, B., Ding, Jeak Ling, Chen, Jianzhu

“…Mechanistically, SARM mediates intrinsic apoptosis via B cell lymphoma-2 (Bcl-2) family members. SARM suppresses B cell lymphoma-extra large (Bcl-xL) and downregulates extracellular signal-regulated kinase phosphorylation, which are cell survival effectors. …”
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TET1 is a tumor suppressor of hematopoietic malignancy by Cimmino, Luisa, Ndiaye-Lobry, Delphine, Yap, Yoon Sing, Bakogianni, Sofia, Yu, Yiting, Bhattacharyya, Sanchari, Shaknovich, Rita, Geng, Huimin, Lobry, Camille, Mullenders, Jasper, King, Bryan, Trimarchi, Thomas, Aranda-Orgilles, Beatriz, Liu, Cynthia, Shen, Steven, Verma, Amit K, Aifantis, Iannis, Dawlaty, Meelad M, Jaenisch, Rudolf

“…Whole-exome sequencing of TET1-deficient tumors revealed mutations frequently found in non-Hodgkin B cell lymphoma (B-NHL), in which TET1 was hypermethylated and transcriptionally silenced. …”
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CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state by Gascoigne, Karen E., Cheeseman, Iain M

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DNA Damage-Mediated Induction of a Chemoresistant Niche by Gilbert, Luke Andrew, Hemann, Michael

“…Here, we use a well-established mouse model of Burkitt's lymphoma to show that paracrine factors in the tumor microenvironment modulate lymphoma cell survival following the administration of genotoxic chemotherapy. …”
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MicroRNA Functions in Stress Responses by Leung, Anthony, Sharp, Phillip A.

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Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres by McKinley, Kara Lavidge, Cheeseman, Iain M

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Induced dicentric chromosome formation promotes genomic rearrangements and tumorigenesis by Gascoigne, Karen E., Cheeseman, Iain M

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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice by Zhao, Zhigang, Chen, Li, Dawlaty, Meelad M., Pan, Feng, Weeks, Ophelia, Zhou, Yuan, Cao, Zeng, Shi, Hui, Wang, Jiapeng, Lin, Li, Chen, Shi, Yuan, Weiping, Qin, Zhaohui, Ni, Hongyu, Nimer, Stephen D., Yang, Feng-Chun, Jaenisch, Rudolf, Jin, Peng, Xu, Mingjiang

“…Tet2 deletion in mice causes myeloid malignancies, while Tet1-null mice develop B cell lymphoma after an extended period of latency. Interestingly, TET1/2 are often concomitantly downregulated in acute B-lymphocytic leukemia. …”
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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc

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A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends by Nicholls, Peter K., Kern, David Matthew, Page, David C, Cheeseman, Iain M

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Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis by Tang, Yun-Chi, Yuwen, Hui, Wang, Kaiying, Bruno, Peter M., Bullock, Kevin, Deik, Amy, Zhong, Na, Huang, Tao, Wang, Lan, Clish, Clary B., Hemann, Michael T., Santaguida, Stefano, Trakala, Marianna, Pfau, Sarah Jeanne, Amon, Angelika B

“…We observed that DL-PDMP could also enhance the cytotoxic effects of paclitaxel, a standard-of-care chemotherapeutic agent that causes aneuploidy, in human colon cancer and mouse lymphoma cells. Our results offer pharmacologic evidence that the aneuploid state in cancer cells can be targeted selectively for therapeutic purposes, or for reducing the toxicity of taxane-based drug regimens.…”
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Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse by Chen, Jianzhu

“…Further characterization of their unique in vivo biology and interaction with both T cells and tumor targets will lead to improvements in cell-based immunotherapies.Trial RegistrationClinicalTrials.gov NCT04024761.FundingDunkin' Donuts, NIH/National Cancer Institute, and the Leukemia and Lymphoma Society.…”
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