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Pulsation and stabilization: Contractile forces that underlie morphogenesis
Published 2011“…Contractile forces generated by the actin–myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. …”
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The Multiple Roles of Cohesin in Meiotic Chromosome Morphogenesis and Pairing
Published 2010“…These findings define Rec8 as a key determinant of meiotic chromosome morphogenesis and a central player in multiple meiotic events.…”
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Actin-based force generation and cell adhesion in tissue morphogenesis
Published 2022“…The generation of organismal form - morphogenesis - arises from forces produced at the cellular level. …”
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Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function
Published 2020“…Background: Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. …”
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Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis
Published 2013“…Tissue morphogenesis is the process in which coordinated movements and shape changes of large numbers of cells form tissues, organs, and the internal body structure. …”
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Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis
Published 2015“…It is not understood whether Myo-II phosphoregulation organizes contractile pulses or whether pulses are important for tissue morphogenesis. Here, we show that Myo-II pulses are associated with pulses of apical Rok. …”
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Epithelial Relaxation Mediated by the Myosin Phosphatase Regulator Mypt1 Is Required for Brain Ventricle Lumen Expansion and Hindbrain Morphogenesis
Published 2011“…We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. …”
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A transitory signaling center controls timing of primordial germ cell differentiation
Published 2022“…Organogenesis requires exquisite spatiotemporal coordination of cell morphogenesis, migration, proliferation, and differentiation of multiple cell types. …”
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Integration of contractile forces during tissue invagination
Published 2011“…Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis.…”
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Perturbation-Expression Analysis Identifies RUNX1 as a Regulator of Human Mammary Stem Cell Differentiation
Published 2015“…We have applied this marker-free approach to screen for transcription factors that regulate mammary stem cell differentiation in a 3D model of tissue morphogenesis and identified RUNX1 as a stem cell regulator. …”
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Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome
Published 2018“…Because pharyngeal arch morphogenesis is compromised in Tbx1-deficient animals, the malformations were considered secondary. …”
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Actin cytoskeleton: Thinking globally, actin’ locally
Published 2014“…Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.…”
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The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Published 2020“…Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. …”
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Quantitative analysis of cell shape and the cytoskeleton in developmental biology
Published 2020“…This review describes current computational approaches that are being used to answer developmental questions related to morphogenesis and describe how these approaches have impacted the field. …”
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Flow-dependent myosin recruitment during Drosophila cellularization requires zygotic dunk activity
Published 2020“…Actomyosin contractility underlies force generation in morphogenesis ranging from cytokinesis to epithelial extension or invagination. …”
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Microtubules promote intercellular contractile force transmission during tissue folding
Published 2020“…These results delineate a role for coordination between actin and microtubule cytoskeletal systems in intercellular force transmission during tissue morphogenesis.…”
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Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis
Published 2012“…These regulated changes and coordination of cytoskeletal and exocytic machinery may be utilized in other physiological contexts involving cell motility and morphogenesis.…”
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