Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice by Feliciano, C., Itohara, S., Dong, X., Zhang, Qiangge, Gao, Xian, Li, Chenchen, Wang, Dongqing, Zhou, Dingxi, Mei, Yuan, Monteiro, Patricia, Anand, Michelle S., Fu, Zhanyan, Feng, Guoping

Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress by Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., Menard, C., Aleyasin, H., Koo, J. W., Lorsch, Z. S., Feng, J., Heshmati, M., Wang, M., Turecki, G., Zhang, B., Shen, L., Nestler, E. J., Russo, S. J., Neve, Rachael L.

“…Associated with this enhanced resilience of female mice upon NAc knock-out of Dnmt3a was a partial shift of the NAc female transcriptome toward the male pattern after SCVS. …”
Get full text
Get full text

Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects by Penney, Jay, Seo, Jinsoo, Kritskiy, Oleg, Elmsaouri, Sara, Gao, Fan, Pao, Ping-Chieh, Su, Susan Chih-Chieh, Tsai, Li-Huei

“…Furthermore, behavioral analyses show that PRMT8 conditional knock-out mice exhibit impaired hippocampal-dependent fear learning. …”
Get full text
Get full text
Get full text
Get full text

Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis by Ge, Xuecai, Frank, Christopher Lee, Calderon de Anda, Froylan, Tsai, Li-Huei

“…Hook3, previously shown to link the centrosome and the nucleus in C. elegans, is recruited to pericentriolar satellites through interaction with PCM1, a protein associated with schizophrenia. Knocking down of Hook3 or PCM1, or disrupting the Hook3-PCM1 interaction in vivo impairs interkinetic nuclear migration, a featured behavior of embryonic neural progenitors. …”
Get full text
Get full text

STAT1 Regulates the Homeostatic Component of Visual Cortical Plasticity via an AMPA Receptor-Mediated Mechanism by Nagakura, Ikue, Van Wart, Audra, Petravicz, Jeremy C., Tropea, Daniela, Sur, Mriganka, Van Wart, Audra

“…After brief monocular deprivation (MD), STAT1 knock-out (KO) mice show an accelerated increase of open-eye responses, to a level comparable with open-eye responses after a longer duration of MD in wild-type (WT) mice. …”
Get full text
Get full text
Get full text
Get full text

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes by Mei, Yuan, Monteiro, Patricia, Zhou, Yang, Kim, Jinah, Gao, Xian, Fu, Zhanyan, Feng, Guoping

“…We generated a novel Shank3 conditional knock-in mouse model, and show that re-expression of the Shank3 gene in adult mice led to improvements in synaptic protein composition, spine density and neural function in the striatum. …”
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text
Get full text

Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission by Kruger, Juliane M., Favaro, Plinio D., Liu, Mingna, Kitlinska, Agata, Huang, Xiaojie, Raabe, Monika, Akad, Derya S., Liu, Yanling, Urlaub, Henning, Dong, Yan, Xu, Weifeng, Schluter, Oliver M.

“…Using molecular manipulations, including overexpression, gene knockdown, PSD-93 knock-out mice combined with biochemical assays, and slice electrophysiology both in rat and mice, we demonstrate that PSD-93 is required at different developmental synaptic states to maintain the strength of excitatory synaptic transmission. …”
Get full text
Get full text
Get full text

Cannabinoid Receptor 1 Is Required for Neurodevelopment of Striosome-Dendron Bouquets by Crittenden, Jill R, Yoshida, Tomoko, Venu, Samitha, Mahar, Ara, Graybiel, Ann M

“…CB1R enrichment was first detectable between postnatal day (P)5 and P7, and this timing coincided with the formation of "striosome-dendron bouquets," the elaborate anatomic structures by which striosomal neurons control dopaminergic cell activity through inhibitory synapses. In Cnr1-/- knock-out mice lacking CB1R expression, striosome-dendron bouquets were markedly disorganized by P11 and at adulthood, suggesting a postnatal pathfinding connectivity function for CB1R in connecting striosomal axons and dopaminergic neurons analogous to CB1R's prenatal function in other brain regions. …”
Get full text

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome by Osterweil, Emily, Krueger, Dilja, Reinhold, Kimberly, Bear, Mark

“…Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. …”
Get full text
Get full text

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors by Sheng, Morgan Hwa-Tze, Fisher, Daniel, Xing, Bin, Dill, John, Li, Hui, Hoang, Hai Hiep, Zhao, Zhenze, Yang, Xiao-Li, Bachoo, Robert, Cannon, Stephen, Longo, Frank M., Silver, Jerry, Li, Shuxin

“…CSPG stimulation enhances activity of LAR phosphatase in vitro. Deletion of LAR in knock-out mice or blockade of LAR with sequence-selective peptides significantly overcomes neurite growth restrictions of CSPGs in neuronal cultures. …”
Get full text

The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex by Nie, Duyu, Chen, Zehua, Ebrahimi-Fakhari, Darius, Di Nardo, Alessia, Julich, Kristina, Robson, Victoria K., Cheng, Yung-Chih, Woolf, Clifford J., Heiman, Myriam, Sahin, Mustafa

“…Importantly, transcripts for the activating transcription factor-3 (Atf3) and mitochondrial uncoupling protein-2 (Ucp2) are highly induced in Tsc2-deficient neurons, as well as in a neuron-specific Tsc1 conditional knock-out mouse model, and show differential responses to the mTOR inhibitor rapamycin. …”
Get full text
Get full text

PSD95 Suppresses Dendritic Arbor Development in Mature Hippocampal Neurons by Occluding the Clustering of NR2B-NMDA Receptors by Bustos, Fernando J., Varela-Nallar, Lorena, Campos, Matias, Henriquez, Berta, Phillips, Marnie, Opazo, Carlos, Aguayo, Luis G., Montecino, Martin, Constantine-Paton, Martha, Inestrosa, Nibaldo C., van Zundert, Brigitte, Phillips, Marnie

“…Using constructs that alter the synaptic composition, we found that either over-expression of NR2B or knock-down of PSD95 by shRNA-PSD95 augmented dendritogenesis in immature neurons. …”
Get full text
Get full text

Sapap3 Deletion Anomalously Activates Short-Term Endocannabinoid-Mediated Synaptic Plasticity by Chen, Meng, Wan, Yehong, Ade, Kristen, Ting, Jonathan, Feng, Guoping, Calakos, Nicole

“…SAP90/PSD-95-associated proteins (SAPAPs) are a family of postsynaptic proteins unique to excitatory synapses. Using Sapap3 knock-out (KO) mice, we find that, in the absence of SAPAP3, striatal medium spiny neuron (MSN) excitatory synapses exhibit eCB-mediated synaptic depression under conditions that do not normally activate this process. …”
Get full text
Get full text

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models by Ding, Qiurong, Lee, Youn-Kyoung, Schaefer, Esperance A.K., Peters, Derek T., Veres, Adrian, Kim, Kevin, Kuperwasser, Nicolas, Motola, Daniel L., Meissner, Torsten B., Hendriks, William T., Trevisan, Marta, Gupta, Rajat M., Moisan, Annie, Banks, Eric, Friesen, Max, Schinzel, Robert T., Xia, Fang, Tang, Alexander, Xia, Yulei, Figueroa, Emmanuel, Wann, Amy, Ahfeldt, Tim, Daheron, Laurence, Zhang, Feng, Rubin, Lee L., Peng, Lee F., Chung, Raymond T., Musunuru, Kiran, Cowan, Chad A.

“…NHEJ can be exploited to introduce small insertions or deletions (indels) resulting in frameshift mutations that effectively knock out a protein-coding gene. An exogenously introduced double-stranded DNA or single-stranded DNA oligonucleotide (ssODN) can serve as a repair template for HDR to incorporate an alteration into the genome (Soldner et al., 2011). …”
Get full text
Get full text